ZFIN ID: ZDB-PERS-030827-2
Huang, Chang-Jen
Email: cjibc@gate.sinica.edu.tw
URL: http://www.bc.sinica.edu.tw/PI_DetailE.asp?Auto=19
Affiliation: Chang-Jen Huang Lab
Address: Institute of Biological Chemistry Academia Sinica 128, Academia Road, Section 2 Nankang, Taipei, 115 Taiwan
Country: Taiwan
Phone: 886-2-278-55696 ext. 5070
Fax: 886-2-278-89759


Wu, C.S., Lu, Y.F., Liu, Y.H., Huang, C.J., Hwang, S.L. (2020) Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression. Developmental Biology. 470:21-36
Lin, K.H., Li, M.W., Chang, Y.C., Lin, Y.N., Ho, Y.H., Weng, W.C., Huang, C.J., Chang, B.E., Yao, C.L., Lee, H. (2017) Activation of Lysophosphatidic Acid Receptor 3 Inhibits Megakaryopoiesis in Human Hematopoietic Stem Cells and Zebrafish. Stem cells and development. 27(3):216-224
Lin, C.Y., Tsai, M.Y., Liu, Y.H., Lu, Y.F., Chen, Y.C., Lai, Y.R., Liao, H.C., Lien, H.W., Yang, C.H., Huang, C.J., Hwang, S.L. (2017) Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression. Journal of Biomedical Science. 24:45
Huang, C.J., Chou, C.M., Lien, H.W., Chu, C.Y., Ho, J.Y., Wu, Y., Cheng, C.H. (2017) IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae. Marine biotechnology (New York, N.Y.). 19(3):310-319
Wang, B.J., Her, G.M., Hu, M.K., Chen, Y.W., Tung, Y.T., Wu, P.Y., Hsu, W.M., Lee, H., Jin, L.W., Hwang, S.L., Chen, R.P., Huang, C.J., Liao, Y.F. (2017) ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 114(15):E3129-E3138
Lin, K.R., Yang-Yen, H.F., Lien, H.W., Liao, W.H., Huang, C.J., Lin, L.I., Li, C.L., Yen, J.J. (2016) Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice. Scientific Reports. 6:31444
Wu, B.K., Yuan, R.Y., Chang, Y.P., Lien, H.W., Chen, T.S., Chien, H.C., Tong, T.S., Tsai, H.P., Fang, C.L., Liao, Y.F., Chang, C.C., Chen, R.P., Huang, C.J. (2016) Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2. Biochemical and Biophysical Research Communications. 477(2):283-9
Lai, Y.R., Lu, Y.F., Lien, H.W., Huang, C.J., Hwang, S.L. (2016) Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos. The Biochemical journal. 473(14):2205-18
Lien, H.W., Yuan, R.Y., Chou, C.M., Chen, Y.C., Hung, C.C., Hu, C.H., Hwang, S.P., Hwang, P.P., Shen, C.N., Chen, C.L., Cheng, C.H., Huang, C.J. (2016) Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α. Scientific Reports. 6:28297
Lin, K.H., Ho, Y.H., Chiang, J.C., Li, M.W., Lin, S.H., Chen, W.M., Chiang, C.L., Lin, Y.N., Yang, Y.J., Chen, C.N., Lu, J., Huang, C.J., Tigyi, G., Yao, C.L., Lee, H. (2016) Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis. Scientific Reports. 6:27050
Guh, Y.J., Yang, C.Y., Liu, S.T., Huang, C.J., Hwang, P.P. (2016) Oestrogen-related receptor α is required for transepithelial H+ secretion in zebrafish. Proceedings. Biological sciences. 283(1825):20152582
Wu, B.K., Yuan, R.Y., Lien, H.W., Hung, C.C., Hwang, P.P., Chen, R.P., Chang, C.C., Liao, Y.F., Huang, C.J. (2016) Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo. Journal of Biomedical Science. 23:25
Chou, C.M., Chen, Y.C., Su, S., Chen, G.D., Huang, K.Y., Lien, H.W., Huang, C.J., Cheng, C.H. (2015) Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Journal of Biomedical Science. 22:102
Tang, C.H., Lai, Y.R., Chen, Y.C., Li, C.H., Lu, Y.F., Chen, H.Y., Lien, H.W., Yang, C.H., Huang, C.J., Wang, C.Y., Kao, C.F., Hwang, S.P. (2014) Expression of zebrafish anterior gradient 2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10. Biochimica et biophysica acta. Gene regulatory mechanisms. 1839(6):425-37
Wu, Y.C., Chen, R.F., Liu, C.Y., Hu, F.R., Huang, C.J., Wang, I.J. (2014) Knockdown of zebrafish blood vessel epicardial substance results in incomplete retinal lamination. TheScientificWorldJournal. 2014:803718
Han, H.W., Chou, C.M., Chu, C.Y., Cheng, C.H., Yang, C.H., Hung, C.C., Hwang, P.P., Lee, S.J., Liao, Y.F., and Huang, C.J. (2014) The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PLoS One. 9(1):e86345
Lien, H.W., Yang, C.H., Cheng, C.H., Liao, Y.F., Han, Y.S., and Huang, C.J. (2013) Zinc finger protein 219-like (ZNF219L) and Sox9a regulate synuclein-gamma2 (sncgb) expression in the developing notochord of zebrafish. Biochemical and Biophysical Research Communications. 442(3-4):189-194
Lien, H.W., Yang, C.H., Cheng, C.H., Hung, C.C., Liao, W.H., Hwang, P.P., Han, Y.S., and Huang, C.J. (2013) A Novel Zinc Finger Protein 219-like (ZNF219L) is Involved in the Regulation of Collagen Type 2 Alpha 1a (col2a1a) Gene Expression in Zebrafish Notochord. International journal of biological sciences. 9(9):872-886
Liao, W.H., Cheng, C.H., Hung, K.S., Chiu, W.T., Chen, G.D., Hwang, P.P., Hwang, S.P., Kuan, Y.S., and Huang, C.J. (2013) Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cellular and molecular life sciences : CMLS. 70(13):2367-81
Wu, Y.C., Liu, C.Y., Chen, Y.H., Chen, R.F., Sun, T.T., Huang, C.J., and Wang, I.J. (2012) Blood vessel epicardial substance (BVES) regulates epidermal tight junction integrity through atypical protein kinase C. The Journal of biological chemistry. 287(47):39887-39897
Chen, C.H., Chu, P.C., Lee, L., Lien, H.W., Lin, T.L., Fan, C.C., Chi, P., Huang, C.J., and Chang, M.S. (2012) Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint Response. PLoS One. 7(3):e33538
Lafont, A.G., Wang, Y.F., Chen, G.D., Liao, B.K., Tseng, Y.C., Huang, C.J., and Hwang, P.P. (2011) Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 26(5):1072-1083
Yang, C.H., Cheng, C.H., Chen, G.D., Liao, W.H., Chen, Y.C., Huang, K.Y., Hwang, P.P., Hwang, S.P., and Huang, C.J. (2011) Zona Pellucida Domain-Containing Protein β-Tectorin is Crucial for Zebrafish Proper Inner Ear Development. PLoS One. 6(8):e23078
Yeh, L.K., Liu, C.Y., Kao, W.W., Huang, C.J., Hu, F.R., Chien, C.L., and Wang, I.J. (2010) Knockdown of zebrafish lumican gene (ZLUM) causes scleral thinning and increased size of scleral coats. The Journal of biological chemistry. 285(36):28141-28155
Chen, Y.C., Wu, B.K., Chu, C.Y., Cheng, C.H., Han, H.W., Chen, G.D., Lee, M.T., Hwang, P.P., Kawakami, K., Chang, C.C., and Huang, C.J. (2010) Identification and characterization of alternative promoters of zebrafish Rtn-4/Nogo genes in cultured cells and zebrafish embryos. Nucleic acids research. 38(14):4635-4650
Chang, L.Y., Harduin-Lepers, A., Kitajima, K., Sato, C., Huang, C.J., Khoo, K.H., and Guérardel, Y. (2009) Developmental regulation of oligosialylation in zebrafish. Glycoconjugate journal. 26(3):247-261
Cruz, S., Shiao, J.C., Liao, B.K., Huang, C.J., and Hwang, P.P. (2009) Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear. The Journal of experimental biology. 212(Pt 5):639-647
Chen, Y.C., Cheng, C.H., Chen, G.D., Hung, C.C., Yang, C.H., Hwang, S.P., Kawakami, K., Wu, B.K., and Huang, C.J. (2009) Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using green fluorescent protein reporter gene. Developmental dynamics : an official publication of the American Association of Anatomists. 238(3):746-754
Tseng, D.Y., Chou, M.Y., Tseng, Y.C., Hsiao, C.D., Huang, C.J., Kaneko, T., and Hwang, P.P. (2009) Effects of Stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. American journal of physiology. Regulatory, integrative and comparative physiology. 296(3):R549-R557
Chu, C.Y., Cheng, C.H., Yang, C.H., and Huang, C.J. (2008) Erythropoietins from teleosts. Cellular and molecular life sciences : CMLS. 65(22):3545-3552
Chu, F.I., Ho, Y., Huang, C.J., and Tzou, D.L. (2007) 1H, 13C and 15N resonance assignments for proapoptotic protein Nix (residue 1 approximately 156) from Danio rerio. Biomolecular NMR assignments. 1(1):29-31
Horng, J.L., Lin, L.Y., Huang, C.J., Katoh, F., Kaneko, T., and Hwang, P.P. (2007) Knockdown of V-ATPase subunit A ({alpha}tp6v1{alpha}) impairs acid secretion and ion balance in zebrafish Danio rerio. American journal of physiology. Regulatory, integrative and comparative physiology. 292(5):R2068-2076
Wang, W.D., Huang, C.J., Lu, Y.F., Hsin, J.P., Prabhakar, V.R., Cheng, C.F., and Hwang, S.P. (2006) Heart-targeted overexpression of Nip3a in zebrafish embryos causes abnormal heart development and cardiac dysfunction. Biochemical and Biophysical Research Communications. 347(4):979-987
Chen, G.D., Chou, C.M., Hwang, S.P., Wang, F.F., Chen, Y.C., Hung, C.C., Chen, J.Y., and Huang, C.J. (2006) Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay. Biochemical and Biophysical Research Communications. 344(1):272-282
Wu, K.M., Huang, C.J., Hwang, S.P., and Chang, Y.S. (2006) Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule. Journal of Biomedical Science. 13(3):345-355
Guerardel, Y., Chang, L.Y., Maes, E., Huang, C.J., and Khoo, K.H. (2006) Glycomic survey mapping of zebrafish identifies unique sialylation pattern. Glycobiology. 16(3):244-257
Chou, C.M., Chen, Y.C., Lee, M.T., Chen, G.D., Lu, I.C., Chen, S.T., and Huang, C.J. (2006) Expression and characterization of a brain-specific protein kinase BSK146 from zebrafish. Biochemical and Biophysical Research Communications. 340(3):767-775
Pan, T.C., Liao, B.K., Huang, C.J., Lin, L.Y., and Hwang, P.P. (2005) Epithelial Ca2+ Channel Expression and Ca2+ uptake in Developing Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 289(4):R1202-1211
Chang, M.H., Huang, C.J., Hwang, S.P., Lu, I.C., Lin, C.M., Kuo, T.F., and Chou, C.M. (2004) Zebrafish heparin-binding neurotrophic factor enhances neurite outgrowth during its development. Biochemical and Biophysical Research Communications. 321(2):502-509
Chang, M.H., Chou, C.M., Hsieh, Y.C., Lu, I.C., Devi, M.K., Chang, J.P., Kuo, T.F., and Huang, C.J. (2004) Identification of 5(')-upstream region of pufferfish ribosomal protein L29 gene as a strong constitutive promoter to drive GFP expression in zebrafish. Biochemical and Biophysical Research Communications. 314(1):9-258
Shentu, H., Wen, H.-J., Mour Her, G., Huang, C.-J., Wu, J.-L., and Hwang, S.-P. (2003) Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein. Genesis (New York, N.Y. : 2000). 37(3):103-112
Hsieh, Y.C., Chang, M.S., Chen, J.Y., Jong-Young Yen, J., Lu, I.C., Chou, C.M., and Huang, C.-J. (2003) Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos. Biochemical and Biophysical Research Communications. 304(4):667-675