ZFIN Person: Costa, Manoel Luis

ZFIN ID: ZDB-PERS-030807-3

ZFIN ID: ZDB-PERS-030807-3

Costa, Manoel Luis

Email:	manoelluiscosta@ufrj.br
URL:	http://lattes.cnpq.br/9678554788147566
Affiliation:	Laboratório de Diferenciação Muscular e Citoesqueleto
Address:	Programa de Pesquisa em Diferenciação Celular Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Sala F2-19, Bloco F-2° Andar Cidade Universitária - Ilha do Fundão Rio de Janeiro, 21949-590 Brazil
Country:	Brazil
Phone:	55-21-3938-6429, 55-21-2237-0844 or 55-21-9989-7315
Fax:	55-21-3938-6480 or 55-21-2237-0844
ORCID ID:	0000-0002-9037-0085

BIOGRAPHY AND RESEARCH INTERESTS

Muscle, cytoskeleton and differentiation.

PUBLICATIONS

Gomes, G., Oliveira, J.L., Costa, M.L., Mermelstein, C., Feitosa, N.M. (2023) Manganese Exposure Induces Cellular Aggregates and the Accumulation of β-Catenin in Skin of Zebrafish Embryos. Zebrafish. 20(4):160-168

do Amaral, M.J., de Andrade Rosa, I., Andrade, S.A., Fang, X., Andrade, L.R., Costa, M.L., Mermelstein, C. (2022) The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles. Biochimica et biophysica acta. Molecular cell research. 1869:119161

Morris, E.A., Bodin, S., Delaval, B., Comunale, F., Georget, V., Costa, M.L., Lutfalla, G., Gauthier-Rouvière, C. (2017) Flotillins control zebrafish epiboly through their role in cadherin-mediated cell-cell adhesion. Biology of the cell. 109(5):210-221

Campos, L.M., Rios, E.A., Guapyassu, L., Midlej, V., Atella, G.C., Herculano-Houzel, S., Benchimol, M., Mermelstein, C., Costa, M.L. (2016) Alterations in zebrafish development induced by simvastatin: Comprehensive morphological and physiological study, focusing on muscle. Experimental biology and medicine (Maywood, N.J.). 241(17):1950-1960

Campos, L.M., Rios, E.A., Midlej, V., Atella, G.C., Herculano-Houzel, S., Benchimol, M., Mermelstein, C., Costa, M.L. (2015) Structural Analysis of Alterations in Zebrafish Muscle Differentiation Induced by Simvastatin and Their Recovery with Cholesterol. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 63(6):427-37

Araujo, G.L., Vieira, A.E., Barreiro, E.J., Lima, L.M., Cardoso, C.N., Emiliano, N.F., Martins, M.T., Souza, S.S., De Souza, A.M., Berto, C., Costa, M.L., Campos, L.M., França, F.D., Tagliati, C.A. (2014) Toxicological in vitro and subchronic evaluation of LASSBio-596. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 73:148-56

Câmara-Pereira, E.S., Campos, L.M., Vannier-Santos, M.A., Mermelstein, C.S., and Costa, M.L. (2009) Distribution of cytoskeletal and adhesion proteins in adult zebrafish skeletal muscle. Histology and histopathology. 24(2):187-196

Costa, M.L., Escaleira, R.C., Jazenko, F., and Mermelstein, C.S. (2008) Cell adhesion in zebrafish myogenesis: Distribution of intermediate filaments, microfilaments, intracellular adhesion structures and extracellular matrix. Cell motility and the cytoskeleton. 65(10):801-815

Souza, A.R., Kozlowski, E.O., Cerqueira, V.R., Castelo-Branco, M.T., Costa, M.L., and Pavão, M.S. (2007) Chondroitin sulfate and keratan sulfate are the major glycosaminoglycans present in the adult zebrafish Danio rerio (Chordata-Cyprinidae). Glycoconjugate journal. 24(9):521-530

Costa, M.L., Escaleira, R., Manasfi, M., Souza, L.F., and Mermelstein, C.S. (2003) Cytoskeletal and cellular adhesion proteins in zebrafish (Danio rerio) myogenesis. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 36(8):1117-1120

Costa, M.L., Escaleira, R.C., Rodrigues, V.B., Manasfi, M., and Mermelstein, C.S. (2002) Some distinctive features of zebrafish myogenesis based on unexpected distributions of the muscle cytoskeletal proteins actin, myosin, desmin, alpha-actinin, troponin and titin. Mechanisms of Development. 116(1-2):95-104

NON-ZEBRAFISH PUBLICATIONS
1: Ojima K, Lin ZX, Andrade IR, Costa ML, Mermelstein C. Distinctive Effects of Cytochalasin B in Chick Primary Myoblasts and Fibroblasts. PLoS One. 2016 Apr 27;11(4):e0154109. doi: 10.1371/journal.pone.0154109. PubMed PMID: 27119825; PubMed Central PMCID: PMC4847871.

2: Possidonio AC, Soares CP, Fontenele M, Morris ER, Mouly V, Costa ML, Mermelstein C. Knockdown of Lmo7 inhibits chick myogenesis. FEBS Lett. 2016 Feb;590(3):317-29. doi: 10.1002/1873-3468.12067. PubMed PMID: 26786059.

3: Oliveira TN, Possidonio AC, Soares CP, Ayres R, Costa ML, Quintas LE, Mermelstein C. The role of Na+/K+-ATPase during chick skeletal myogenesis. PLoS One. 2015 Mar 16;10(3):e0120940. doi: 10.1371/journal.pone.0120940. PubMed PMID: 25775465; PubMed Central PMCID: PMC4361648.

4: Possidonio AC, Soares CP, Portilho DM, Midlej V, Benchimol M, Butler-Browne G, Costa ML, Mermelstein C. Differences in the expression and distribution of flotillin-2 in chick, mice and human muscle cells. PLoS One. 2014 Aug
8;9(8):e103990. doi: 10.1371/journal.pone.0103990. PubMed PMID: 25105415; PubMed Central PMCID: PMC4126691.

5: Possidonio AC, Miranda M, Gregoracci GB, Thompson FL, Costa ML, Mermelstein C. Cholesterol depletion induces transcriptional changes during skeletal muscle differentiation. BMC Genomics. 2014 Jun 30;15:544. doi: 10.1186/1471-2164-15-544. PubMed PMID: 24981252; PubMed Central PMCID: PMC4092213.

6: Abrunhosa VM, Soares CP, Batista Possidonio AC, Alvarenga AV, Costa-Felix RP, Costa ML, Mermelstein C. Induction of skeletal muscle differentiation in vitro by therapeutic ultrasound. Ultrasound Med Biol. 2014 Mar;40(3):504-12. doi:
10.1016/j.ultrasmedbio.2013.10.013. PubMed PMID: 24412173.

7: Filgueiras Mde C, Morrot A, Soares PM, Costa ML, Mermelstein C. Effects of 5-fluorouracil in nuclear and cellular morphology, proliferation, cell cycle, apoptosis, cytoskeletal and caveolar distribution in primary cultures of smooth
muscle cells. PLoS One. 2013 Apr 30;8(4):e63177. doi:10.1371/journal.pone.0063177. PubMed PMID: 23646193; PubMed Central PMCID:PMC3639966.

8: Portilho DM, Soares CP, Morrot A, Thiago LS, Butler-Browne G, Savino W, Costa ML, Mermelstein C. Cholesterol depletion by methyl-β-cyclodextrin enhances cell proliferation and increases the number of desmin-positive cells in myoblast cultures. Eur J Pharmacol. 2012 Nov 5;694(1-3):1-12. doi:10.1016/j.ejphar.2012.07.035. PubMed PMID: 22921450.

9: Pontes Soares C, Midlej V, de Oliveira ME, Benchimol M, Costa ML, Mermelstein C. 2D and 3D-organized cardiac cells shows differences in cellular morphology, adhesion junctions, presence of myofibrils and protein expression. PLoS One.
2012;7(5):e38147. doi: 10.1371/journal.pone.0038147. PubMed PMID: 22662278; PubMed Central PMCID: PMC3360656.

10: Possidonio AC, Senna ML, Portilho DM, Pontes Soares C, da Silva Sampaio L, Einicker-Lamas M, Castelo Branco MT, Costa ML, Mermelstein C. α-Cyclodextrin enhances myoblast fusion and muscle differentiation by the release of IL-4.
Cytokine. 2011 Aug;55(2):280-7. doi: 10.1016/j.cyto.2011.04.018. PubMed PMID:21570315.

11: Thiago LS, Costa ES, Lopes DV, Otazu IB, Nowill AE, Mendes FA, Portilho DM, Abreu JG, Mermelstein CS, Orfao A, Rossi MI, Borojevic R. The Wnt signaling pathway regulates Nalm-16 b-cell precursor acute lymphoblastic leukemic cell line survival and etoposide resistance. Biomed Pharmacother. 2010 Jan;64(1):63-72.
doi: 10.1016/j.biopha.2009.09.005. PubMed PMID: 19864107.

12: Portilho DM, Martins ER, Costa ML, Mermelstein CS. A soluble and active form of Wnt-3a protein is involved in myogenic differentiation after cholesterol depletion. FEBS Lett. 2007 Dec 22;581(30):5787-95. PubMed PMID: 18037380.

13: Mermelstein CS, Portilho DM, Mendes FA, Costa ML, Abreu JG. Wnt/beta-catenin pathway activation and myogenic differentiation are induced by cholesterol depletion. Differentiation. 2007 Mar;75(3):184-92. PubMed PMID: 17359297.

14: Mermelstein CS, Martins ER, Portilho DM, Costa ML. Association between the muscle-specific proteins desmin and caveolin-3 in muscle cells. Cell Tissue Res. 2007 Feb;327(2):343-51. PubMed PMID: 17036228.

15: Mermelstein CS, Andrade LR, Portilho DM, Costa ML. Desmin filaments are stably associated with the outer nuclear surface in chick myoblasts. Cell Tissue Res. 2006 Feb;323(2):351-7. PubMed PMID: 16160856.

16: Mermelstein CS, Amaral LM, Rebello MI, Reis JS, Borojevic R, Costa ML. Changes in cell shape and desmin intermediate filament distribution are associated with down-regulation of desmin expression in C2C12 myoblasts grown in the absence of extracellular Ca2+. Braz J Med Biol Res. 2005 Jul;38(7):1025-32. PubMed PMID: 16007273.

17: Costa ML, Escaleira R, Cataldo A, Oliveira F, Mermelstein CS. Desmin:molecular interactions and putative functions of the muscle intermediate filament protein. Braz J Med Biol Res. 2004 Dec;37(12):1819-30. Review. PubMed PMID:
15558188.

18: Mermelstein CS, Portilho DM, Medeiros RB, Matos AR, Einicker-Lamas M, Tortelote GG, Vieyra A, Costa ML. Cholesterol depletion by methyl-beta-cyclodextrin enhances myoblast fusion and induces the formation of
myotubes with disorganized nuclei. Cell Tissue Res. 2005 Feb;319(2):289-97. PubMed PMID: 15549398.

19: Mermelstein CS, Guma FC, Mello TG, Fortuna VA, Guaragna RM, Costa ML, Borojevic R. Induction of the lipocyte phenotype in murine hepatic stellate cells: reorganisation of the actin cytoskeleton. Cell Tissue Res. 2001
Oct;306(1):75-83. PubMed PMID: 11683184.

20: Guma FCR, Mello TG, Mermelstein CS, Fortuna VA, Wofchuk ST, Gottfried C, Guaragna RM, Costa ML, Borojevic R. Intermediate filaments modulation in an in vitro model of the hepatic stellate cell activation or conversion into the
lipocyte phenotype. Biochem Cell Biol. 2001;79(4):409-17. PubMed PMID: 11527210.