ZFIN ID: ZDB-PERS-030801-2
Jonz, Michael G.
Email: mgjonz@gmail.com
URL: http://www.bio.uottawa.ca/scripts/mbr-e.php?id=73
Address: Department of Biology University of Ottawa 30 Marie Curie Ottawa, ON, K1N 6N5 Canada
Phone: 613-562-5800 ext 6051
Fax: 613-562-5486

I am interested in the structure, function and development of oxygen sensing mechanisms in vertebrates. Recently, I have begun to explore the potential of the zebrafish gill preparation as a model to study oxygen chemoreceptors, and to understand how oxygen sensing may have evolved in vertebrates.

I incorporate techniques of immunocytochemistry, confocal microscopy and patch-clamp electrophysiology to study the morphology and function of neuroepithelial cells (NECs) of the gill. These cells are peripheral oxygen chemoreceptors in fish and appear to be phylogenetically related to oxygen chemoreceptors in mammals, such as those of the carotid body. NECs are innervated and fully functional at about 7 days postfertilization in gill primordia of zebrafish larvae.

Pan, W., Scott, A.L., Nurse, C.A., Jonz, M.G. (2021) Identification of oxygen-sensitive neuroepithelial cells through an endogenous reporter gene in larval and adult transgenic zebrafish. Cell and tissue research. 384(1):35-47
Cadiz, L., Jonz, M.G. (2020) A comparative perspective on lung and gill regeneration. The Journal of experimental biology. 223(Pt 19):
Mierzwa, A.S., Nguyen, F., Xue, M., Jonz, M.G. (2019) Regeneration of the gill filaments and replacement of serotonergic neuroepithelial cells in adult zebrafish (Danio rerio). Respiratory Physiology & Neurobiology. 274:103366
Coe, A.J., Picard, A.J., Jonz, M.G. (2017) Purinergic and adenosine receptors contribute to hypoxic hyperventilation in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 214:50-57
Stoyek, M.R., Jonz, M.G., Smith, F.M., Croll, R.P. (2017) Distribution and chronotropic effects of serotonin in the zebrafish heart. Autonomic neuroscience : basic & clinical. 206:43-50
Dean, B.W., Rashid, T.J., Jonz, M.G. (2017) Mitogenic action of hypoxia upon cutaneous neuroepithelial cells in developing zebrafish. Developmental Neurobiology. 77(6):789-801
Zachar, P.C., Pan, W., Jonz, M.G. (2017) Distribution and morphology of cholinergic cells in the branchial epithelium of zebrafish (Danio rerio). Cell and tissue research. 367(2):169-179
Rahbar, S., Pan, W., Jonz, M.G. (2016) Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. PLoS One. 11:e0154261
Jonz, M.G., Buck, L.T., Perry, S.F., Schwerte, T., Zaccone, G. (2016) Sensing and surviving hypoxia in vertebrates. Annals of the New York Academy of Sciences. 1365(1):43-58
Abdallah, S.J., Jonz, M.G., Perry, S.F. (2015) Extracellular H(+) induces Ca (2+) signals in respiratory chemoreceptors of zebrafish. Pflugers Archiv : European journal of physiology. 467(2):399-413
Jackson, R., Braubach, O.R., Bilkey, J., Zhang, J., Akimenko, M.A., Fine, A., Croll, R.P., and Jonz, M.G. (2013) Expression of sall4 in taste buds of zebrafish. Developmental Neurobiology. 73(7):543-58
Shakarchi, K., Zachar, P.C., and Jonz, M.G. (2013) Serotonergic and cholinergic elements of the hypoxic ventilatory response in developing zebrafish. The Journal of experimental biology. 216(5):869-880
Zhang, D., Xi, Y., Coccimiglio, M.L., Mennigen, J.A., Jonz, M., Ekker, M., and Trudeau, V.L. (2012) Functional prediction and physiological characterization of a novel short trans-membrane protein 1 (Stmp1) as a subunit of mitochondrial respiratory complexes. Physiological Genomics. 44(23):1133-1140
Coccimiglio, M.L., and Jonz, M.G. (2012) Serotonergic neuroepithelial cells of the skin in developing zebrafish: morphology, innervation and oxygen-sensitive properties. The Journal of experimental biology. 215(22):3881-3894
Zachar, P.C., and Jonz, M.G. (2012) Confocal imaging of Merkel-like basal cells in the taste buds of zebrafish. Acta histochemica. 114(2):101-115
Abdallah, S.J., Perry, S.F., and Jonz, M.G. (2012) CO(2) Signaling in Chemosensory Neuroepithelial Cells of the Zebrafish Gill Filaments: Role of Intracellular Ca(2+) and pH. Advances in experimental medicine and biology. 758:143-148
Zachar, P.C., and Jonz, M.G. (2012) Oxygen sensitivity of gill neuroepithelial cells in the anoxia-tolerant goldfish. Advances in experimental medicine and biology. 758:167-172
Jonz, M.G., and Nurse, C.A. (2008) New developments on gill innervation: insights from a model vertebrate. The Journal of experimental biology. 211(Pt 15):2371-2378
Jonz, M.G., and Nurse, C.A. (2006) Ontogenesis of oxygen chemoreception in aquatic vertebrates. Respiratory Physiology & Neurobiology. 154(1-2):139-152
Jonz, M.G., and Nurse, C.A. (2006) Epithelial mitochondria-rich cells and associated innervation in adult and developing zebrafish. The Journal of comparative neurology. 497(5):817-832
Saltys, H.A., Jonz, M.G., and Nurse, C.A. (2006) Comparative study of gill neuroepithelial cells and their innervation in teleosts and Xenopus tadpoles. Cell and tissue research. 323(1):1-10
Vessey, J.P., Stratis, A.K., Daniels, B.A., Da Silva, N., Jonz, M.G., Lalonde, M.R., Baldridge, W.H., and Barnes, S. (2005) Proton-mediated feedback inhibition of presynaptic calcium channels at the cone photoreceptor synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(16):4108-4117
Jonz, M.G., and Nurse, C.A. (2005) Development of oxygen sensing in the gills of zebrafish. The Journal of experimental biology. 208(Pt.8):1537-1549
Jonz, M.G. (2005) Structure, function and development of oxygen-sensitive neuroepithelial cells of the gills of zebrafish (Danio rerio). Ph.D. Thesis. :205p
Jonz, M.G., Fearon, I.M., and Nurse, C.A. (2004) Neuroepithelial oxygen chemoreceptors of the zebrafish gill. The Journal of physiology. 560(Pt 3):737-52
Jonz, M.G. and Nurse, C.A. (2003) Neuroepithelial cells and associated innervation of the zebrafish gill: a confocal immunofluorescence study. The Journal of comparative neurology. 461(1):1-17
Jonz, M.G., Fearon, I.M., and Nurse, C.A. (2003) Potential oxygen sensing pathways in the zebrafish gill. Advances in experimental medicine and biology. 536:217-223