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ZFIN ID:
ZDB-PERS-030721-1
Cunliffe, Vincent
Email:
v.t.cunliffe@shef.ac.uk
URL:
Affiliation:
Cunliffe Lab
Address:
Centre for Developmental Genetics School of Medicine and Biomedical Science University of Sheffield Firth Court Western Bank Sheffield , S10 2TN United Kingdom
Country:
United Kingdom
Phone:
011-44-114-222-2389
Fax:
011-44-114-222-2788
ORCID ID:
BIOGRAPHY AND RESEARCH INTERESTS
PUBLICATIONS
Eachus, H., Oberski, L., Paveley, J., Bacila, I., Ashton, J.P., Esposito, U., Seifuddin, F., Pirooznia, M., Elhaik, E., Placzek, M., Krone, N., Cunliffe, V.T. (2023) Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain. Disease models & mechanisms. 16(9):
Pinho, J.S., Cunliffe, V., Kareklas, K., Petri, G., Oliveira, R.F. (2023) Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation. Communications biology. 6:633633
Jubber, I., Morhardt, D.R., Griffin, J., Cumberbatch, M., Glover, M., Zheng, Y., Rehman, I., Loynes, C., Hussain, S.A., Renshaw, S.A., Leach, S.D., Cunliffe, V.T., Catto, J.W.F. (2023) Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system. Disease models & mechanisms. 16(7):
Jones, A., Barker-Haliski, M., Ilie, A.S., Herd, M.B., Baxendale, S., Holdsworth, C.J., Ashton, J.P., Placzek, M., Jayasekera, B.A.P., Cowie, C.J.A., Lambert, J.J., Trevelyan, A.J., White, H.S., Marson, A.G., Cunliffe, V.T., Sills, G.J., Morgan, A. (2020) A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant. Epilepsia. 61(10):2106-2118
Oakes, J.A., Barnard, L., Storbeck, K.H., Cunliffe, V.T., Krone, N.P. (2020) 11β-hydroxylase loss disrupts steroidogenesis and reproductive function in zebrafish. The Journal of endocrinology. 247(2):197-212
Marchi, D., Santhakumar, K., Markham, E., Li, N., Storbeck, K.H., Krone, N., Cunliffe, V.T., van Eeden, F.J.M. (2020) Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae. PLoS Genetics. 16:e1008757
Li, N., Oakes, J.A., Storbeck, K., Cunliffe, V.T., Krone, N. (2019) The P450 side chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish. The Journal of endocrinology. 244(2):309-321
Oakes, J.A., Li, N., Wistow, B.R.C., Griffin, A., Barnard, L., Storbeck, K.H., Cunliffe, V.T., Krone, N.P. (2019) Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis and feminization in zebrafish. Endocrinology. 160(10):2401-2416
Chhabria, K., Plant, K., Bandmann, O., Wilkinson, R.N., Martin, C., Kugler, E., Armitage, P.A., Santoscoy, P.L., Cunliffe, V.T., Huisken, J., McGown, A., Ramesh, T., Chico, T.J., Howarth, C. (2018) The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 40(2):298-313
Bergmann, K., Meza Santoscoy, P., Lygdas, K., Nikolaeva, Y., MacDonald, R.B., Cunliffe, V.T., Nikolaev, A. (2018) Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish. Journal of developmental biology. 6(1)
Pickering, J., Cunliffe, V.T., Van Eeden, F., Borycki, A.G. (2017) Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm. Matrix biology : journal of the International Society for Matrix Biology. 62:58-74
Eachus, H., Zaucker, A., Oakes, J.A., Griffin, A., Weger, M., Güran, T., Taylor, A., Harris, A., Greenfield, A., Quanson, J.L., Storbeck, K.H., Cunliffe, V.T., Müller, F., Krone, N. (2017) Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology. 158(12):4165-4173
Eachus, H., Bright, C., Cunliffe, V.T., Placzek, M., Wood, J.D., Watt, P.J. (2017) Disrupted-In-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Human molecular genetics. 26(11):1992-2005
Cunliffe, V.T. (2016) Building a zebrafish toolkit for investigating the pathobiology of epilepsy and identifying new treatments for epileptic seizures. Journal of Neuroscience Methods. 260:91-5
Cunliffe, V.T. (2016) Histone modifications in zebrafish development. Methods in cell biology. 135:361-85
Boyd, P.J., Cunliffe, V.T., Roy, S., Wood, J.D. (2015) Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open. 4(10):1336-43
Jackson, H.E., Ono, Y., Wang, X., Elworthy, S., Cunliffe, V.T., Ingham, P.W. (2015) The role of Sox6 in zebrafish muscle fiber type specification. Skeletal muscle. 5:2
Johnson, M.R., Behmoaras, J., Bottolo, L., Krishnan, M.L., Pernhorst, K., Santoscoy, P.L., Rossetti, T., Speed, D., Srivastava, P.K., Chadeau-Hyam, M., Hajji, N., Dabrowska, A., Rotival, M., Razzaghi, B., Kovac, S., Wanisch, K., Grillo, F.W., Slaviero, A., Langley, S.R., Shkura, K., Roncon, P., De, T., Mattheisen, M., Niehusmann, P., O'Brien, T.J., Petrovski, S., von Lehe, M., Hoffmann, P., Eriksson, J., Coffey, A.J., Cichon, S., Walker, M., Simonato, M., Danis, B., Mazzuferi, M., Foerch, P., Schoch, S., De Paola, V., Kaminski, R.M., Cunliffe, V.T., Becker, A.J., Petretto, E. (2015) Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nature communications. 6:6031
Cunliffe, V.T., Baines, R.A., Giachello, C.N., Lin, W.H., Morgan, A., Reuber, M., Russell, C., Walker, M.C., Williams, R.S. (2015) Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms. Seizure. 24C:44-51
Baxendale, S., Holdsworth, C.J., Santoscoy, P.M., Harrison, M.R., Fox, J., Parkin, C.A., Ingham, P.W., and Cunliffe, V.T. (2012) Identification of compounds with novel anti-convulsant properties in a zebrafish model of epileptic seizures. Disease models & mechanisms. 5(6):773-784
Harrison, M.R., Georgiou, A.S., Spaink, H.P., and Cunliffe, V.T. (2011) The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos. BMC Genomics. 12(1):24
Lightman, E.G., Harrison, M.R., and Cunliffe, V.T. (2011) Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis. The International journal of developmental biology. 55(6):597-602
Butler, R., Wood, J.D., Landers, J.A., and Cunliffe, V.T. (2010) Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia. Disease models & mechanisms. 3(11-12):743-751
Wood, J.D., Bonath, F., Kumar, S., Ross, C.A., and Cunliffe, V.T. (2009) Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain. Human molecular genetics. 18(3):391-404
Prajsnar, T.K., Cunliffe, V.T., Foster, S.J., and Renshaw, S.A. (2008) A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens. Cellular Microbiology. 10(11):2312-2325
Wood, J.D., Landers, J.A., Bingley, M., McDermott, C.J., Thomas-McArthur, V., Gleadall, L.J., Shaw, P.J., and Cunliffe, V.T. (2006) The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo. Human molecular genetics. 15(18):2763-2771
Cunliffe, V.T., and Casaccia-Bonnefil, P. (2006) Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS. Mechanisms of Development. 123(1):24-30
Cunliffe, V.T. (2004) Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling. Development (Cambridge, England). 131(12):2983-2995
NON-ZEBRAFISH PUBLICATIONS
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