ZFIN ID: ZDB-PERS-030612-10
Harris, Matthew
Email: Matthew.Harris@childrens.harvard.edu
URL: http://genetics.med.harvard.edu/faculty/harris
Affiliation: Matthew Harris Lab
Address: Orthopaedic Research Laboratories Children's Hospital Boston Harvard Medical School 300 Longwood Ave Enders 260 Boston, MA 02115 USA
Country: United States
Phone: 001.617.919.2032

Research into the genetics underlying change in adult form of the zebrafish and the developmetnal basis of evolutionary change

Kaliya-Perumal, A.K., Celik, C., Carney, T.J., Harris, M.P., Ingham, P.W. (2024) Genetic regulation of injury induced heterotopic ossification in adult zebrafish. Disease models & mechanisms. 17(5):
Blum, N., Harris, M.P. (2023) Localized heterochrony integrates overgrowth potential of oncogenic clones. Disease models & mechanisms. 16(2):
Miao, K.Z., Cozzone, A., Caetano-Lopes, J., Harris, M.P., Fisher, S. (2022) Osteoclast activity sculpts craniofacial form to permit sensorineural patterning in the zebrafish skull. Frontiers in endocrinology. 13:969481
Khrystoforova, I., Shochat-Carvalho, C., Harari, R., Henke, K., Woronowicz, K., Harris, M.P., Karasik, D. (2022) Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation. Frontiers in endocrinology. 13:985304
Meyer-Miner, A., Van Gennip, J.L.M., Henke, K., Harris, M.P., Ciruna, B. (2022) Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model. iScience. 25:105028
Daane, J.M., Blum, N., Lanni, J., Boldt, H., Iovine, M.K., Higdon, C.W., Johnson, S.L., Lovejoy, N.R., Harris, M.P. (2021) Modulation of bioelectric cues in the evolution of flying fishes. Current biology : CB. 31(22):5052-5061.e8
Hawkins, M.B., Henke, K., Harris, M.P. (2021) Latent developmental potential to form limb-like skeletal structures in zebrafish. Cell. 184(4):899-911.e13
Samuels, B.D., Aho, R., Brinkley, J.F., Bugacov, A., Feingold, E., Fisher, S., Gonzalez-Reiche, A.S., Hacia, J.G., Hallgrimsson, B., Hansen, K., Harris, M.P., Ho, T.V., Holmes, G., Hooper, J.E., Jabs, E.W., Jones, K.L., Kesselman, C., Klein, O.D., Leslie, E.J., Li, H., Liao, E.C., Long, H., Lu, N., Maas, R.L., Marazita, M.L., Mohammed, J., Prescott, S., Schuler, R., Selleri, L., Spritz, R.A., Swigut, T., van Bakel, H., Visel, A., Welsh, I., Williams, C., Williams, T.J., Wysocka, J., Yuan, Y., Chai, Y. (2020) FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research. Development (Cambridge, England). 147(18):
Peskin, B., Henke, K., Cumplido, N., Treaster, S., Harris, M.P., Bagnat, M., Arratia, G. (2020) Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. Current biology : CB. 30(14):2805-2814.e3
Rose, C.D., Pompili, D., Henke, K., Van Gennip, J.L.M., Meyer-Miner, A., Rana, R., Gobron, S., Harris, M.P., Nitz, M., Ciruna, B. (2020) SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. Current biology : CB. 30(12):2363-2373.e6
Daane, J.M., Dornburg, A., Smits, P., MacGuigan, D.J., Hawkins, M.B., Near, T.J., Detrich, H.W., Harris, M.P. (2020) Author Correction: Historical contingency shapes adaptive radiation in Antarctic fishes. Nature ecology & evolution. 4:659
Coulter, M.E., Musaev, D., DeGennaro, E.M., Zhang, X., Henke, K., James, K.N., Smith, R.S., Hill, R.S., Partlow, J.N., Muna Al-Saffar, ., Kamumbu, A.S., Hatem, N., Barkovich, A.J., Aziza, J., Chassaing, N., Zaki, M.S., Sultan, T., Burglen, L., Rajab, A., Al-Gazali, L., Mochida, G.H., Harris, M.P., Gleeson, J.G., Walsh, C.A. (2020) Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival. Genetics in medicine : official journal of the American College of Medical Genetics. 22(6):1040-1050
Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
Caetano-Lopes, J., Henke, K., Urso, K., Duryea, J., Charles, J.F., Warman, M.L., Harris, M.P. (2020) Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development (Cambridge, England). 147(2):
Lanni, J.S., Peal, D., Ekstrom, L., Chen, H., Stanclift, C., Bowen, M.E., Mercado, A., Gamba, G., Kahle, K.T., Harris, M.P. (2019) Integrated K+ channel and K+Cl- cotransporter function are required for the coordination of size and proportion during development. Developmental Biology. 456(2):164-178
Daane, J.M., Dornburg, A., Smits, P., MacGuigan, D.J., Brent Hawkins, M., Near, T.J., William Detrich Iii, H., Harris, M.P. (2019) Historical contingency shapes adaptive radiation in Antarctic fishes. Nature ecology & evolution. 3(7):1102-1109
Urso, K., Caetano-Lopes, J., Lee, P.Y., Yan, J., Henke, K., Sury, M., Liu, H., Zgoda, M., Jacome-Galarza, C., Nigrovic, P.A., Duryea, J., Harris, M.P., Charles, J.F. (2019) A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Bone. 127:104-113
Webster, K.A., Henke, K., Ingalls, D.M., Nahrin, A., Harris, M.P., Siegfried, K.R. (2019) Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germ line of zebrafish. Reproduction (Cambridge, England). 157(4):383-398
Gistelinck, C., Kwon, R.Y., Malfait, F., Symoens, S., Harris, M.P., Henke, K., Hawkins, M.B., Fisher, S., Sips, P., Guillemyn, B., Bek, J.W., Vermassen, P., De Saffel, H., Witten, P.E., Weis, M., De Paepe, A., Eyre, D.R., Willaert, A., Coucke, P.J. (2018) Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Proceedings of the National Academy of Sciences of the United States of America. 115(34):E8037-E8046
Daane, J.M., Lanni, J., Rothenberg, I., Seebohm, G., Higdon, C.W., Johnson, S.L., Harris, M.P. (2018) Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin. Scientific Reports. 8:10391
Harris, M.P., Arratia, G. (2018) Patterning the spine. eLIFE. 7
Parsons, K.J., Son, Y.H., Crespel, A., Thambithurai, D., Killen, S., Harris, M.P., Albertson, R.C. (2018) Conserved but flexible modularity in the zebrafish skull: implications for craniofacial evolvability. Proceedings. Biological sciences. 285(1877)
Henke, K., Daane, J.M., Hawkins, M.B., Dooley, C.M., Busch-Nentwich, E.M., Stemple, D.L., Harris, M.P. (2017) Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form.. Genetics. 207(2):609-623
Charles, J.F., Sury, M., Tsang, K., Urso, K., Henke, K., Huang, Y., Russell, R., Duryea, J., Harris, M.P. (2017) Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis. Bone. 101:162-171
Witten, P.E., Harris, M.P., Huysseune, A., Winkler, C. (2017) Small teleost fish provide new insights into human skeletal diseases. Methods in cell biology. 138:321-346
Brinkley, J.F., Fisher, S., Harris, M.P., Holmes, G., Hooper, J.E., Jabs, E.W., Jones, K.L., Kesselman, C., Klein, O.D., Maas, R.L., Marazita, M.L., Selleri, L., Spritz, R.A., van Bakel, H., Visel, A., Williams, T.J., Wysocka, J., Chai, Y. (2016) The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development (Cambridge, England). 143:2677-88
Daane, J.M., Rohner, N., Konstantinidis, P., Djuranovic, S., Harris, M.P. (2016) Parallelism and epistasis in skeletal evolution identified through use of phylogenomic mapping strategies. Molecular Biology and Evolution. 33(1):162-73
Harris, M.P., Hawkins, M.B. (2015) Out of the Mouth of Minnows. Developmental Cell. 35:263-4
Hu, W.F., Pomp, O., Ben-Omran, T., Kodani, A., Henke, K., Mochida, G.H., Yu, T.W., Woodworth, M.B., Bonnard, C., Raj, G.S., Tan, T.T., Hamamy, H., Masri, A., Shboul, M., Al Saffar, M., Partlow, J.N., Al-Dosari, M., Alazami, A., Alowain, M., Alkuraya, F.S., Reiter, J.F., Harris, M.P., Reversade, B., Walsh, C.A. (2014) Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number. Neuron. 84:1240-1257
Perathoner, S., Daane, J.M., Henrion, U., Seebohm, G., Higdon, C.W., Johnson, S.L., Nüsslein-Volhard, C., and Harris, M.P. (2014) Bioelectric signaling regulates size in zebrafish fins. PLoS Genetics. 10(1):e1004080
Henke, K., Bowen, M.E., and Harris, M.P. (2013) Identification of mutations in zebrafish using next-generation sequencing. Current Protocols in Moledular Biology. 104:Unit 7.13
Henke, K., Bowen, M.E., and Harris, M.P. (2013) Perspectives for identification of mutations in the zebrafish: Making use of next-generation sequencing technologies for forward genetic approaches. Methods (San Diego, Calif.). 62(3):185-96
Levesque, M.P., Krauss, J., Koehler, C., Boden, C., and Harris, M.P. (2013) New Tools for the Identification of Developmentally Regulated Enhancer Regions in Embryonic and Adult Zebrafish. Zebrafish. 10(1):21-9
Dauber, A., Lafranchi, S.H., Maliga, Z., Lui, J.C., Moon, J.E., McDeed, C., Henke, K., Zonana, J., Kingman, G.A., Pers, T.H., Baron, J., Rosenfeld, R.G., Hirschhorn, J.N., Harris, M.P., and Hwa, V. (2012) Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein. The Journal of clinical endocrinology and metabolism. 97(11):E2140-2151
Bowen, M.E., Henke, K., Siegfried, K.R., Warman, M.L., and Harris, M.P. (2012) Efficient Mapping and Cloning of Mutations in Zebrafish by Low-Coverage Whole-Genome Sequencing. Genetics. 190(3):1017-1024
Chen, Y.Y., Harris, M.P., Levesque, M.P., Nüsslein-Volhard, C., and Sonawane, M. (2012) Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes. Mechanisms of Development. 129(1-4):13-23
Norton, W.H., Stumpenhorst, K., Faus-Kessler, T., Folchert, A., Rohner, N., Harris, M.P., Callebert, J., and Bally-Cuif, L. (2011) Modulation of Fgfr1a Signaling in Zebrafish Reveals a Genetic Basis for the Aggression-Boldness Syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(39):13796-13807
Rohner, N., Perathoner, S., Frohnhöfer, H.G., and Harris, M.P. (2011) Enhancing the Efficiency of N-Ethyl-N-Nitrosourea-Induced Mutagenesis in the Zebrafish. Zebrafish. 8(3):119-23
Volkmann, K., Chen, Y.Y., Harris, M.P., Wullimann, M.F., and Köster, R.W. (2010) The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. The Journal of comparative neurology. 518(14):2794-2817
Rohner, N., Bercsényi, M., Orbán, L., Kolanczyk, M.E., Linke, D., Brand, M., Nüsslein-Volhard, C., and Harris, M.P. (2009) Duplication of fgfr1 Permits Fgf Signaling to Serve as a Target for Selection during Domestication. Current biology : CB. 19(19):1642-1647
Harris, M.P., Rohner, N., Schwarz, H., Perathoner, S., Konstantinidis, P., and Nüsslein-Volhard, C. (2008) Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genetics. 4(10):e1000206