ZFIN Person: Chan, King-Ming

ZFIN ID: ZDB-PERS-021112-3

Chan, King-Ming

Email:	kingchan@cuhk.edu.hk
URL:	http://www.bch.cuhk.edu.hk/academic_staff.asp?tuid=40002
Affiliation:
Address:	Department of Biochemistry 513 Basic Medical Sciences Building The Chinese University of Hong Kong Shatin, New Territories Hong Kong, Hong Kong
Country:
Phone:	(852) 260-96867
Fax:	(852) 260-35123
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Meng, Q., Yeung, K., Chan, K.M. (2021) Toxic effects of octocrylene on zebrafish larvae and liver cell line (ZFL). Aquatic toxicology (Amsterdam, Netherlands). 236:105843

Kwok, M.L., Li, Z.P., Law, T.Y.S., Chan, K.M. (2020) Promotion of cadmium uptake and cadmium-induced toxicity by the copper transporter CTR1 in HepG2 and ZFL cells. Toxicology reports. 7:1564-1570

Kwok, M.L., Meng, Q., Hu, X.L., Chung, C.T., Chan, K.M. (2020) Whole-transcriptome sequencing (RNA-seq) study of the ZFL zebrafish liver cell line after acute exposure to Cd²⁺ ions. Aquatic toxicology (Amsterdam, Netherlands). 228:105628

Kwok, M.L., Chan, K.M. (2020) Oxidative stress and apoptotic effects of copper and cadmium in the zebrafish liver cell line ZFL. Toxicology reports. 7:822-835

Meng, Q., Yeung, K., Kwok, M.L., Chung, C.T., Hu, X.L., Chan, K.M. (2020) Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones. Environmental pollution (Barking, Essex : 1987). 265:114857

Li, Z.P., Kwok, M.L., Samuel, T.Y.L., Cheung, K.C.P., Chan, K.M. (2020) Functional analyses of copper transporter genes in the human liver cell line HepG2. Toxicology in vitro : an international journal published in association with BIBRA. 66:104856

Kwok, M.L., Hu, X.L., Meng, Q., Chan, K.M. (2020) Whole-transcriptome sequencing (RNA-seq) analyses of the zebrafish liver cell line, ZFL, after acute exposure to Cu²⁺ ions. Metallomics : integrated biometal science. 12(5):732-751

Kwok, M.L., Chan, K.M. (2019) Functional characterization of copper transporters zCtr1, zAtox1, zAtp7a and zAtp7b in zebrafish liver cell line ZFL. Metallomics : integrated biometal science. 11(9):1532-1546

Mak, C.W., Ching-Fong Yeung, K., Chan, K.M. (2019) Acute toxic effects of polyethylene microplastic on adult zebrafish. Ecotoxicology and environmental safety. 182:109442

Chen, Y.Y., Chan, K.M. (2018) Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd²⁺in vivo.. Chemosphere. 210:577-587

Yang, J., Zhao, H., Chan, K.M. (2017) Toxic effects of polybrominated diphenyl ethers (BDE 47 and 99) and localization of BDE-99-induced cyp1a mRNA in zebrafish larvae.. Toxicology reports. 4:614-624

Chen, Y.Y., Chan, K.M. (2017) Transcriptional inhibition of TCDD-mediated induction of cytochrome P450 1A1 and alteration of protein expression in a zebrafish hepatic cell line following the administration of TCDD and Cd².. Toxicology letters. 282:121-135

Zhou, Z., Yang, J., Chan, K.M. (2017) Toxic effects of triclosan on a zebrafish (Danio rerio) liver cell line, ZFL. Aquatic toxicology (Amsterdam, Netherlands). 191:175-188

Yang, J., Zhu, J., Chan, K.M. (2016) BDE-99, but not BDE-47, is a Transient Aryl Hydrocarbon Receptor Agonist in Zebrafish Liver Cells. Toxicology and applied pharmacology. 305:203-15

Chen, Y.Y., Chan, K.M. (2016) Regulation of vitellogenin (vtg1) and estrogen receptor (er) gene expression in zebrafish (Danio rerio) following the administration of Cd(2+) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Chemosphere. 147:467-476

Chen, Y.Y., Chan, K.M. (2016) Differential effects of metal ions on TCDD-induced cytotoxicity and cytochrome P4501A1 gene expression in a zebrafish liver (ZFL) cell-line. Metallomics : integrated biometal science. 8(2):236-51

Leung, K.P., Chen, D., Chan, K.M. (2014) Understanding copper sensitivity in zebrafish (Danio rerio) through the intracellular localization of copper transporters in a hepatocyte cell-line ZFL and the tissue expression profiles of copper transporters. Metallomics : integrated biometal science. 6:1057-67

Chow, W.S., Chan, W.K., and Chan, K.M. (2013) Toxicity assessment and vitellogenin expression in zebrafish (Danio rerio) embryos and larvae acutely exposed to bisphenol A, endosulfan, heptachlor, methoxychlor and tetrabromobisphenol A. Journal of applied toxicology : JAT. 33(7):670-8

Zhu, J.Y., and Chan, K.M. (2012) Mechanism of cadmium-induced cytotoxicity on the ZFL zebrafish liver cell line. Metallomics : integrated biometal science. 4(10):1064-1076

Chan, W.K., and Chan, K.M. (2012) Disruption of the hypothalamic-pituitary-thyroid axis in zebrafish embryo-larvae following waterborne exposure to BDE-47, TBBPA and BPA. Aquatic toxicology (Amsterdam, Netherlands). 108:109-111

Chen, D., Zhang, D., Yu, J.C., and Chan, K.M. (2011) Effects of Cu²O nanoparticle and CuCl₂ on zebrafish larvae and a liver cell-line. Aquatic toxicology (Amsterdam, Netherlands). 105(3-4):344-354

Chen, D.S., and Chan, K.M. (2011) PCR-cloning of tilapia ATP7A cDNA and its mRNA levels in tissues of tilapia following copper administrations. Aquatic toxicology (Amsterdam, Netherlands). 105(3-4):717-727

Chen, D.S., and Chan, K.M. (2011) Differentially expressed proteins in zebrafish liver cells exposed to copper. Aquatic toxicology (Amsterdam, Netherlands). 104(3-4):270-277

Jia, J., Yu, J.C., Wang, Y.X., and Chan, K.M. (2010) Magnetic Nanochains of FeNi(3) Prepared by a Template-Free Microwave-Hydrothermal Method. ACS applied materials & interfaces. 2(9):2579-2584

Wan, G., Cheuk, W.K., and Chan, K.M. (2009) Differential regulation of zebrafish metallothionein-II (zMT-II) gene transcription in ZFL and SJD cell lines by metal ions. Aquatic toxicology (Amsterdam, Netherlands). 91(1):33-43

Cheuk, W.K., Chan, P.C., and Chan, K.M. (2008) Cytotoxicities and induction of metallothionein (MT) and metal regulatory element (MRE)-binding transcription factor-1 (MTF-1) messenger RNA levels in the zebrafish (Danio rerio) ZFL and SJD cell lines after exposure to various metal ions. Aquatic toxicology (Amsterdam, Netherlands). 89(2):103-112

Chan, K.M., Ku, L.L., Chan, P.C., and Cheuk, W.K. (2006) Metallothionein gene expression in zebrafish embryo-larvae and ZFL cell-line exposed to heavy metal ions. Marine Environmental Research. 62 Suppl 1:S83-87

Li, W.H., Chan, P.C., and Chan, K.M. (2004) Metal uptake in zebrafish embryo-larvae exposed to metal-contaminated sediments. Marine Environmental Research. 58(2-5):829-832

Yan, C.H., and Chan, K.M. (2004) Cloning of zebrafish metallothionein gene and characterization of its gene promoter region in HepG2 cell line. BBA Gene Structure and Expression. 1679(1):47-58

Yan, C.H.-M. and Chan, K.M. (2002) Characterization of zebrafish metallothionein gene promoter in a zebrafish caudal fin cell-line, SJD. 1. Marine Environmental Research. 54(3-5):335-339

NON-ZEBRAFISH PUBLICATIONS