ZFIN ID: ZDB-PERS-011217-4
Voz, Marianne
Email: mvoz@ulg.ac.be
URL: http://www.giga.ulg.ac.be/cms/c_25784/fr/zebrafish-development-and-disease-models-laboratory-home
Affiliation: Laboratory of Zebrafish Development and Disease Models
Address: GIGA Laboratory of Zebrafish Development and Disease Models Avenue de l'Hôpital 1, bât B 34 4000 SART TILMAN – Belgium
Country: Belgium
Phone: 32-4-366-3691
Fax: 0032-4-366.41.98

From zebrafish to human disease : deciphering the molecular steps of pancreas formation, regeneration and carcinogenesis.

Our laboratory is dedicated to identify molecular mechanisms controlling the generation of pancreatic cells in normal and disease state, using the zebrafish as animal model. To achieve this goal, we use a combination of transcriptomics (RNA sequencing or "RNAseq"), mutagenesis, and transgenesis and we create zebrafish models mimicking pancreatic diseases. For more informations about our project, please visit our web site http://www.giga.ulg.ac.be/zddm

Reuter, A.S., Stern, D., Bernard, A., Goossens, C., Lavergne, A., Flasse, L., Von Berg, V., Manfroid, I., Peers, B., Voz, M.L. (2022) Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. PLoS Genetics. 18:e1010109
Mousavy Gharavy, S.N., Owen, B.M., Millership, S.J., Chabosseau, P., Pizza, G., Martinez-Sanchez, A., Tasoez, E., Georgiadou, E., Hu, M., Fine, N.H.F., Jacobson, D.A., Dickerson, M.T., Idevall-Hagren, O., Montoya, A., Kramer, H., Mehta, Z., Withers, D.J., Ninov, N., Gadue, P.J., Cardenas-Diaz, F.L., Cruciani-Guglielmacci, C., Magnan, C., Ibberson, M., Leclerc, I., Voz, M., Rutter, G.A. (2021) Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Diabetologia. 64(4):850-864
Lavergne, A., Tarifeño-Saldivia, E., Pirson, J., Reuter, A.S., Flasse, L., Manfroid, I., Voz, M.L., Peers, B. (2020) Pancreatic and intestinal endocrine cells in zebrafish share common transcriptomic signatures and regulatory programmes. BMC Biology. 18:109
Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Ghesquière, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., Rorive, A., Jerusalem, G., Leucci, E., Dewaele, M., Vooijs, M., Leidel, S.A., Georges, M., Voz, M., Peers, B., Büttner, R., Marine, J.C., Chariot, A., Close, P. (2018) Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature. 558:605-609
Bergemann, D., Massoz, L., Bourdouxhe, J., Carril Pardo, C.A., Voz, M.L., Peers, B., Manfroid, I. (2018) Nifurpirinol : a more potent and reliable substrate compared to metronidazole for nitroreductase-mediated cell ablations. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 26(2):238-244
Tarifeño-Saldivia, E., Lavergne, A., Bernard, A., Padamata, K., Bergemann, D., Voz, M.L., Manfroid, I., Peers, B. (2017) Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. BMC Biology. 15:21
Janssen, L., Dupont, L., Bekhouche, M., Noel, A., Leduc, C., Voz, M., Peers, B., Cataldo, D., Apte, S.S., Dubail, J., Colige, A. (2016) ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 19(1):53-65
Ghaye, A.P., Bergemann, D., Tarifeño-Saldivia, E., Flasse, L.C., Von Berg, V., Peers, B., Voz, M.L., Manfroid, I. (2015) Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration. BMC Biology. 13:70
Flasse, L.C., Pirson, J.L., Stern, D.G., Von Berg, V., Manfroid, I., Peers, B., and Voz, M.L. (2013) Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biology. 11(1):78
Flasse, L., Stern, D.G., Pirson, J.L., Manfroid, I., Peers, B., and Voz, M.L. (2013) The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine. Developmental Biology. 376(2):187-197
Manfroid, I., Ghaye, A., Naye, F., Detry, N., Palm, S., Pan, L., Ma, T.P., Huang, W., Rovira, M., Martial, J.A., Parsons, M.J., Moens, C.B., Voz, M.L., and Peers, B. (2012) Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Developmental Biology. 366(2):268-278
Naye, F., Voz, M.L., Detry, N., Hammerschmidt, M., Peers, B., and Manfroid, I. (2012) Essential roles of zebrafish bmp2a, fgf10 and fgf24 in the specification of the ventral pancreas. Molecular biology of the cell. 23(5):945-954
Voz, M.L., Coppieters, W., Manfroid, I., Baudhuin, A., Von Berg, V., Charlier, C., Meyer, D., Driever, W., Martial, J.A., and Peers, B. (2012) Fast Homozygosity Mapping and Identification of a Zebrafish ENU-Induced Mutation by Whole-Genome Sequencing. PLoS One. 7(4):e34671
Verbruggen, V., Ek, O., Georlette, D., Delporte, F., Von Berg, V., Detry, N., Biemar, F., Coutinho, P., Martial, J.A., Voz, M.L., Manfroid, I., and Peers, B. (2010) The Pax6b homeodomain is dispensable for pancreatic endocrine cell differentiation in zebrafish. The Journal of biological chemistry. 285(18):13863-13873
Binot, A.C., Manfroid, I., Flasse, L., Winandy, M., Motte, P., Martial, J.A., Peers, B., and Voz, M.L. (2010) Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells. Developmental Biology. 340(2):397-407
Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., Ravassard, P., Vermot, J., Voz, M.L., Mellitzer, G., and Gradwohl, G. (2010) Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (Cambridge, England). 137(2):203-212
Delporte, F.M., Pasque, V., Devos, N., Manfroid, I., Voz, M.L., Motte, P., Biemar, F., Martial, J.A., and Peers, B. (2008) Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factors. BMC Developmental Biology. 8:53
Pendeville, H., Winandy, M., Manfroid, I., Nivelles, O., Motte, P., Pasque, V., Peers, B., Struman, I., Martial, J.A., and Voz, M.L. (2008) Zebrafish Sox7 and Sox18 function together to control arterial-venous identity. Developmental Biology. 317(2):405-416
Manfroid, I., Delporte, F., Baudhuin, A., Motte, P., Neumann, C.J., Voz, M.L., Martial, J.A., and Peers, B. (2007) Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development. Development (Cambridge, England). 134(22):4011-4021
Peeters, H., Voz, M.L., Verschueren, K., De Cat, B., Pendeville, H., Thienpont, B., Schellens, A., Belmont, J.W., David, G., Van De Ven, W.J., Fryns, J.P., Gewillig, M., Huylebroeck, D., Peers, B., and Devriendt, K. (2006) Sesn1 is a Novel Gene for Left-Right Asymmetry and Mediating Nodal Signaling. Human molecular genetics. 15(22):3369-3377
Nichane, M., Van Campenhout, C., Pendeville, H., Voz, M.L., and Bellefroid, E.J. (2006) The Na(+)/PO(4) cotransporter SLC20A1 gene labels distinct restricted subdomains of the developing pronephros in Xenopus and zebrafish embryos. Gene expression patterns : GEP. 6(7):667-672
Van Campenhout, C., Nichane, M., Antoniou, A., Pendeville, H., Bronchain, O.J., Marine, J.C., Mazabraud, A., Voz, M.L., and Bellefroid, E.J. (2006) Evi1 is specifically expressed in the distal tubule and duct of the Xenopus pronephros and plays a role in its formation. Developmental Biology. 294(1):203-219
Pendeville, H., Peers, B., Kas, K., and Voz, M.L. (2006) Cloning and embryonic expression of zebrafish PLAG genes. Gene expression patterns : GEP. 6(3):267-276

Kas, K., Voz, M. L., Roijer, E., Astrom, A. K., Meyen, E., Stenman, G., and Van de Ven, W. J. Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet, 15: 170-174, 1997.

Voz, M. L., Astrom, A. K., Kas, K., Mark, J., Stenman, G., and Van de Ven, W. J. The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter. Oncogene, 16: 1409-1416., 1998.

Kas, K., Voz, M. L., Hensen, K., Meyen, E., and Van de Ven, W. J. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J Biol Chem, 273: 23026-23032., 1998

Astrom, A. K., Voz, M. L., Kas, K., Roijer, E., Wedell, B., Mandahl, N., Van de Ven, W., Mark, J., and Stenman, G. Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene. Cancer Res, 59: 918-923., 1999.

Voz, M. L., Agten, N. S., Van de Ven, W. J., and Kas, K. PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II. Cancer Res, 60: 106-113., 2000

Debiec-Rychter, M., Van Valckenborgh, I., Van den Broeck, C., Hagemeijer, A., Van de Ven, W. J., Kas, K., Van Damme, B., and Voz, M. L. Histologic localization of PLAG1 in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells, Lab Invest. 81: 1289-97., 2001

Hensen, K., Van Valckenborgh, I. C., Kas, K., Van de Ven, W. J., and Voz, M. L. The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities. Cancer Res, 62: 1510-1517., 2002.

Voz, M.L,, Mathys J., H. K., Pendeville H, Van Valckenborgh I, Van Huffel C, Chavez M.V., Van Damme B, De Moor B, Moreau Y, Van de Ven WJM. Microarray screening for target genes of the proto-oncogene PLAG1. Oncogene, 23: 179-191, 2004.