ZFIN ID: ZDB-PERS-010517-1
Ablooglu, Ararat
Email: aablooglu@ucsd.edu
URL:
Affiliation:
Address: University of California San Diego Department of Medicine 9500 Gilman Dr, Mail Stop 0726 Leichtag Research Bldg Room 132-MM La Jolla, CA 92093 USA
Country:
Phone: (858) 822-6578
Fax: (858) 822-6444
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Weijts, B., Gutierrez, E., Saikin, S.K., Ablooglu, A.J., Traver, D., Groisman, A., Tkachenko, E. (2018) Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. Nature communications. 9:5314
Fitzpatrick, P., Shattil, S.J., Ablooglu, A.J. (2014) C-terminal COOH of Integrin beta1 Is Necessary for beta1 Association with the Kindlin-2 Adapter Protein. The Journal of biological chemistry. 289:11183-93
Liu, J.J., Stockton, R.A., Gingras, A.R., Ablooglu, A.J., Han, J., Bobkov, A.A., Ginsberg, M.H. (2011) A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Molecular biology of the cell. 22:2509-19
Ablooglu, A.J., Tkachenko, E., Kang, J., and Shattil, S.J. (2010) Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development (Cambridge, England). 137(20):3449-3458
Ablooglu, A.J., Kang, J., Handin, R.I., Traver, D., and Shattil, S.J. (2007) The zebrafish vitronectin receptor: Characterization of integrin alphaV and beta3 expression patterns in early vertebrate development. Developmental dynamics : an official publication of the American Association of Anatomists. 236(8):2268-2276

NON-ZEBRAFISH PUBLICATIONS
Sturr, M. G., Ablooglu, A. J., and Krulwich, T. A. (1997). A Bacillus subtilis locus encoding several gene products affecting transport of cations. Gene 188, 91-94.

Cann, A. D., Bishop, S. M., Ablooglu, A. J., and Kohanski, R. A. (1998). Partial activation of the insulin receptor kinase domain by juxtamembrane autophosphorylation. Biochemistry 37, 11289-11300.

Frankel, M., Bishop, S. M., Ablooglu, A. J., Han, Y. P., and Kohanski, R. A. (1999). Conformational changes in the activation loop of the insulin receptor's kinase domain. Protein Sci. 8, 2158-2165.

Ablooglu, A. J., Till, J. H., Kim, K., Parang, K., Cole, P. A., Hubbard, S. R., and Kohanski, R. A. (2000). Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate. J. Biol. Chem. 275, 30394-30398.

Till, J. H., Ablooglu, A. J., Frankel, M., Bishop, S. M., Kohanski, R.A., and Hubbard, S. R. (2001). Crystallographic and Solution Studies of an Activation Loop Mutant of the Insulin Receptor Tyrosine Kinase: Insights into Kinase Mechanism. J. Biol. Chem. 276, 10049-10055.

Ablooglu, A. J., and Kohanski, R. A. (2001). Activation of the Insulin Receptor's Kinase Domain Changes the Rate- Determining Step of Substrate Phosphorylation. Biochemistry 40, 504-513.

Ablooglu, A. J.,* Parang, K.,* Till, J. H.,* Kohanski, R. A., Hubbard, S. R., and Cole, P. A. (2001). Mechanism-based design of a protein kinase inhibitor. Nat. Struct. Biol. 8, 37-41.

Frankel, M. F., Ablooglu, A. J., Leone, J. W., Rusinova, E., Ross, J.B.A., Heinrikson, R. L., and Kohanski, R. A. (2001). Intrasteric Inhibition of ATP Binding is not Required to Prevent Unregulated Autophosphorylation or Signaling By the Insulin Receptor. Mol. Cell. Biol. 21, 4197-4207.

Ablooglu, A. J., Frankel, M., Rusinova, E., Ross, J. B. A., and Kohanski, R. A. (2001). Multiple Activation Loop Conformations and their Regulatory Properties the Insulin Receptor’s Kinase Domain. J. Biol. Chem. 276, 46933-40.

Petrich, B. G., Fogelstrand, R., Partridge, A. W., Yousefi, N., Ablooglu, A. J., Shattil, S. J., and Ginsberg, M. H. (2007). The Anti-Thrombotic Potential of Selective Blockade of Talin-Dependent Integrin ±IIb²3 (Platelet GPIIb-IIIa) Activation. The Journal of Clinical Investigation 117, 2250-2259.

Ablooglu. A.J., Kang J., Petrich B.G., Ginsberg M.H., and Shattil S.J. (2009). Anti-Thrombotic Effects of Targeting ±IIbβ3 Signaling in Platelets. Blood 113, 3585-3592.