ZFIN Person: Wardle, Fiona

ZFIN ID: ZDB-PERS-010326-2

ZFIN ID: ZDB-PERS-010326-2

Wardle, Fiona

Email:	fiona.wardle@kcl.ac.uk
URL:	http://www.kcl.ac.uk/lsm/research/divisions/randall/research/sections/signalling/wardle/index.aspx
Affiliation:	Wardle Lab
Address:	Randall Division of Cell and Molecular Biophysics New Hunt's House King's College London Guy's Campus London, SE1 1UL United Kingdom
Country:	United Kingdom
Phone:	+ 44 (0)20 7848 6469
Fax:	+ 44 (0)20 7848 6435
ORCID ID:	0000-0001-5444-1889

BIOGRAPHY AND RESEARCH INTERESTS

Transcriptional regulation of mesoderm and endoderm formation in zebrafish

PUBLICATIONS

Gomes, M.C., Brokatzky, D., Bielecka, M.K., Wardle, F.C., Mostowy, S. (2023) Shigella induces epigenetic reprogramming of zebrafish neutrophils. Science advances. 9:eadf9706eadf9706

Talbot, C.D., Walsh, M.D., Cutty, S.J., Elsayed, R., Vlachaki, E., Bruce, A.E.E., Wardle, F.C., Nelson, A.C. (2022) Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops. Frontiers in cell and developmental biology. 10:982477

Baranasic, D., Hörtenhuber, M., Balwierz, P.J., Zehnder, T., Mukarram, A.K., Nepal, C., Várnai, C., Hadzhiev, Y., Jimenez-Gonzalez, A., Li, N., Wragg, J., D'Orazio, F.M., Relic, D., Pachkov, M., Díaz, N., Hernández-Rodríguez, B., Chen, Z., Stoiber, M., Dong, M., Stevens, I., Ross, S.E., Eagle, A., Martin, R., Obasaju, O., Rastegar, S., McGarvey, A.C., Kopp, W., Chambers, E., Wang, D., Kim, H.R., Acemel, R.D., Naranjo, S., Łapiński, M., Chong, V., Mathavan, S., Peers, B., Sauka-Spengler, T., Vingron, M., Carninci, P., Ohler, U., Lacadie, S.A., Burgess, S.M., Winata, C., van Eeden, F., Vaquerizas, J.M., Gómez-Skarmeta, J.L., Onichtchouk, D., Brown, B.J., Bogdanovic, O., van Nimwegen, E., Westerfield, M., Wardle, F.C., Daub, C.O., Lenhard, B., Müller, F. (2022) Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements. Nature Genetics. 54(7):1037-1050

López-Pérez, A.R., Balwierz, P.J., Lenhard, B., Muller, F., Wardle, F.C., Manfroid, I., Voz, M.L., Peers, B. (2021) Identification of downstream effectors of retinoic acid specifying the zebrafish pancreas by integrative genomics. Scientific Reports. 11:22717

Osborn, D.P.S., Li, K., Cutty, S.J., Nelson, A.C., Wardle, F.C., Hinits, Y., Hughes, S.M. (2020) Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis. Development (Cambridge, England). 147(8):

Nelson, A.C., Cutty, S.J., Gasiunas, S.N., Deplae, I., Stemple, D.L., Wardle, F.C. (2017) In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors. Cell Reports. 19:2782-2795

Gomes, R.S., Skroblin, P., Munster, A.B., Tomlins, H., Langley, S.R., Zampetaki, A., Yin, X., Wardle, F., Mayr, M. (2016) "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Journal of Molecular and Cellular Cardiology. 92:105-8

Windner, S.E., Doris, R.A., Ferguson, C.M., Nelson, A.C., Valentin, G., Tan, H., Oates, A.C., Wardle, F.C., Devoto, S.H. (2015) Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish. Development (Cambridge, England). 142(6):1159-68

Nelson, A.C., Cutty, S.J., Niini, M., Stemple, D.L., Flicek, P., Houart, C., Bruce, A., Wardle, F.C. (2014) Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC Biology. 12:81

Wardle, F., Muller, F. (2014) Fish genomics: casting the net wide. Briefings in Functional Genomics. 13:79-81

Jahangiri, L., Nelson, A.C., Wardle, F.C. (2012) A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites. Developmental Biology. 371:110-120

Evans, A.L., Faial, T., Gilchrist, M.J., Down, T., Vallier, L., Pedersen, R.A., Wardle, F.C., and Smith, J.C. (2012) Genomic targets of brachyury (T) in differentiating mouse embryonic stem cells. PLoS One. 7(3):e33346

Cutty, S.J., Fior, R., Henriques, P.M., Saude, L., and Wardle, F.C. (2012) Identification and expression analysis of two novel members of the Mesp family in zebrafish. The International journal of developmental biology. 56(4):285-294

Morley, R.H., Lachani, K., Keefe, D., Gilchrist, M.J., Flicek, P., Smith, J.C., and Wardle, F.C. (2009) A gene regulatory network directed by zebrafish No tail accounts for its roles in mesoderm formation. Proceedings of the National Academy of Sciences of the United States of America. 106(10):3829-3834

Garnett, A.T., Han, T.M., Gilchrist, M.J., Smith, J.C., Eisen, M.B., Wardle, F.C., and Amacher, S.L. (2009) Identification of direct T-box target genes in the developing zebrafish mesoderm. Development (Cambridge, England). 136(5):749-760

Wardle, F.C., and Papaioannou, V.E. (2008) Teasing out T-box targets in early mesoderm. Current opinion in genetics & development. 18(5):418-425

von Hofsten, J., Elworthy, S., Gilchrist, M.J., Smith, J.C., Wardle, F.C., and Ingham, P.W. (2008) Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. EMBO reports. 9(7):683-689

Wardle, F.C., Odom, D.T., Bell, G.W., Yuan, B., Danford, T.W., Wiellette, E.L., Herbolsheimer, E., Sive, H.L., Young, R.A., and Smith, J.C. (2006) Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome biology. 7(8):R71

Hoyle, J., Tang, Y.P., Wiellette, E.L., Wardle, F.C., and Sive, H. (2004) nlz Gene family is required for hindbrain patterning in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 229(4):835-846

NON-ZEBRAFISH PUBLICATIONS
Wardle, F.C., Tan H. (2015) A ChIP on the shoulder? Chromatin immunoprecipitation and validation strategies for ChIP antibodies. F1000Research 2015, 4:235.

Nelson , A.C., Wardle, F.C., (2013) Conserved non-coding elements and cis-regulation: actions speak louder than words. Development 140, 1385-95.

Nelson, A.C., Pillay, N., Henderson, S., Presneau, N., Tirabosco, R., Halai, D., Berisha, F., Flicek, P., Stemple, D.L., Stern, C., Wardle, F.C., Flanagan, A.M. (2012). A gene regulatory network directed by T, brachyury gives insight into the pathogenesis of chordoma. Journal of Pathology, 228, 274-85.

Wardle, F.C., Sive, H.L. (2003). What’s your position: The Xenopus cement gland as a paradigm of regional specification. Bioessays 25, 717-726.

Wardle, F.C., Smith, J.C. (2006). Transcriptional regulation of mesendoderm formation in Xenopus. Sem Cell Dev Biol 17, 99-109.

Messenger, N.J., Kabitschke, C. Andrews, R., Grimmer, D., Núñez Miguel, R., Blundell, T.L., Smith, J.C., Wardle, F.C. (2005). Functional specificity of the T-domain protein Brachyury is conferred by its ability to interact with Smad1. Dev Cell 8, 599-610.

Taverner, N., Smith, J.C., Wardle, F.C. (2004). Identifying Transcriptional Targets. Genome Biology 5, 210

Wardle, F.C., Smith, J.C. (2004). Refinement of gene expression patterns in the early Xenopus embryo. Development 131, 4687-4696.

Bromley, E., Knapp, D., Wardle, F.C., Sun, B.I., LaVallie, E., Smith, J.C., Sive, H.L. (2004). Identification and Characterization of fullback and fullback-like two Novel Xenopus Neurotrophin Receptor Homolog Genes. Gene Expression Patterns 5, 135-140

Wardle, F.C., Wainstock, D., Sive, H. (2002). Cement gland-specific activation of the Xag1 promoter is regulated by co-operation of Ets and ATF/CREB-like binding sites. Development 129 4387-4397.

Dale, L., Wardle, F.C. (1999). A gradient of BMP activity specifies dorsal-ventral fate in the early Xenopus embryo. Sem. Cell Dev. Bio. 10, 319-326.

Wardle, F.C., Welch, J.V., Dale, L. (1999). Bone Morphogenetic Protein 1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading Chordin, a BMP4 antagonist. Mech. Dev. 86 (1-2), 75-85.

Wardle, F.C., Angerer, L.M., Angerer, R.C., Dale, L. (1999). Regulation of BMP signalling by the BMP1/Tld-related metalloproteinase, SpAN. Dev. Biol. 206, 63-72.

Goodman, S.A., Albano, R., Wardle, F.C., Matthews, G., Tannahill, D., Dale, L. (1998). BMP1-related metalloproteinases promote the development of ventral mesoderm in the early Xenopus embryo. Dev. Biol. 195, 144-157.

Tannahill, D., Wardle, F.C. (1995). Control of axis formation in Xenopus by the NF-κB-IκB system. Intl. J. Dev. Biol. 39, 549-558.