ZFIN Person: Wu, Jen-Leih

ZFIN ID: ZDB-PERS-000913-1

ZFIN ID: ZDB-PERS-000913-1

Wu, Jen-Leih

Email:	jlwu@gate.sinica.edu.tw
URL:	http://www.sinica.edu.tw/zool/english/jlwu.htm
Affiliation:	Jen-Leih Wu Lab
Address:	Laboratory of Marine Molecular Biology and Biotechnology Institute of Zoology Academia Sinica Nankang Taipei, 11529 Taiwan
Country:	Taiwan
Phone:	886-2-2789-9568
Fax:	886-2-2782-4595
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Chu, W.K., Huang, S.C., Chang, C.F., Wu, J.L., Gong, H.Y. (2023) Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Frontiers in genetics. 14:10292001029200

Hung, J.C., Wu, J.L., Li, H.C., Chiu, H.W., Hong, J.R. (2021) The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish. Cells. 10(11):

Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):

Hung, J.C., Wu, J.L., Hong, J.R. (2021) Proapoptotic Bad Involved in Brain Development, When Severely Defected, Induces Dramatic Malformation in Zebrafish. International Journal of Molecular Sciences. 22(9):

Lin, C.R., Chu, T.M., Luo, A., Huang, S.J., Chou, H.Y., Lu, M.W., Wu, J.L. (2019) Omega-3 polyunsaturated fatty acids suppress metastatic features of human cholangiocarcinoma cells by suppressing twist. The Journal of Nutritional Biochemistry. 74:108245

Wu, S.H., Chou, H.Y., Liu, P.C., Wu, J.L., Gong, H.Y. (2019) Granulin peptide GRN-41 of Mozambique tilapia is a novel antimicrobial peptide against Vibrio species. Biochemical and Biophysical Research Communications. 515(4):706-711

Wu, S.H., Lin, H.J., Lin, W.F., Wu, J.L., Gong, H.Y. (2018) A potent tilapia secreted granulin peptide enhances the survival of transgenic zebrafish infected by Vibrio vulnificus via modulation of innate immunity. Fish & shellfish immunology. 75:74-90

Huang, S.J., Cheng, C.L., Chen, J.R., Gong, H.Y., Liu, W., Wu, J.L. (2017) Inducible liver-specific overexpression of gankyrin in zebrafish results in spontaneous intrahepatic cholangiocarcinoma and hepatocellular carcinoma formation. Biochemical and Biophysical Research Communications. 490(3):1052-1058

Li, Y.W., Chiang, K.Y., Li, Y.H., Wu, S.Y., Liu, W., Lin, C.R., Wu, J.L. (2017) MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling. PLoS One. 12:e0177887

You, M.S., Jiang, Y.J., Yuh, C.H., Wang, C.M., Tang, C.H., Chuang, Y.J., Lin, B.H., Wu, J.L., Hwang, S.L. (2016) A Sketch of the Taiwan Zebrafish Core Facility. Zebrafish. 13 Suppl 1:S24-9

Shiu, W.L., Huang, K.R., Hung, J.C., Wu, J.L., Hong, J.R. (2016) Knockdown of zebrafish YY1a can downregulate the phosphatidylserine (PS) receptor expression, leading to induce the abnormal brain and heart development. Journal of Biomedical Science. 23:31

Cheng, C.L., Huang, S.J., Wu, C.L., Gong, H.Y., Ken, C.F., Hu, S.Y., Wu, J.L. (2015) Transgenic expression of omega-3 PUFA synthesis genes improves zebrafish survival during Vibrio vulnificus infection. Journal of Biomedical Science. 22:103

Li, Y.H., Luo, J., Mosley, Y.Y., Hedrick, V.E., Paul, L.N., Chang, J., Zhang, G., Wang, Y.K., Banko, M.R., Brunet, A., Kuang, S., Wu, J.L., Chang, C.J., Scott, M.P., Yang, J.Y. (2015) AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Reports. 12:599-609

Chen, H.Y., Liu, W., Wu, S.Y., Chiou, P.P., Li, Y.H., Chen, Y.C., Lin, G.H., Lu, M.W., Wu, J.L. (2015) RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish & shellfish immunology. 43(2):427-35

Wang, Y.D., Peng, K.C., Wu, J.L., Chen, J.Y. (2014) Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish & shellfish immunology. 39(2):223-30

Lin, H.J., Lee, S.H., Wu, J.L., Duann, Y.F., and Chen, J.Y. (2013) Development of Cre-loxP technology in zebrafish to study the regulation of fish reproduction. Fish physiology and biochemistry. 39(6):1525-39

Lu, J.W., Yang, W.Y., Tsai, S.M., Lin, Y.M., Chang, P.H., Chen, J.R., Wang, H.D., Wu, J.L., Jin, S.L., and Yuh, C.H. (2013) Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish. PLoS One. 8(10):e76951

Chen, W., Tseng, X., Lin, G., Schreiner, A., Chen, H., Voigt, M.M., Yuh, C., Wu, J., Huang, S.S., and Huang, J. (2013) The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish. CellBio. 2(4):228-247

Huang, H.L., Liu, Y.T., Chen, M.C., Wu, J.L., and Hong, J.R. (2011) Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins. Fish & shellfish immunology. 31(6):970-7

Pan, C.Y., Wu, J.L., Hui, C.F., Lin, C.H., and Chen, J.Y. (2011) Insights into the antibacterial and immunomodulatory functions of the antimicrobial peptide, epinecidin-1, against Vibrio vulnificus infection in zebrafish. Fish & shellfish immunology. 31(6):1019-25

Wu, C.L., Lin, T.H., Chang, T.L., Sun, H.W., Hui, C.F., and Wu, J.L. (2011) Zebrafish HSC70 promoter to express carp muscle-specific creatine kinase for acclimation under cold condition. Transgenic Research. 20(6):1217-26

Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C., and Wu, J.L. (2011) Activation of cytokine expression occurs through the tnfα/nf-κb-mediated pathway in birnavirus-infected cells. Fish & shellfish immunology. 31(1):10-21

Wang, W.L., Hong, J.R., Lin, G.H., Liu, W., Gong, H.Y., Lu, M.W., Lin, C.C., and Wu, J.L. (2011) Stage-Specific Expression of TNFα Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells. PLoS One. 6(2):e16740

Li, Y.H., Chen, M.H., Gong, H.Y., Hu, S.Y., Li, Y.W., Lin, G.H., Lin, C.C., Liu, W., and Wu, J.L. (2010) Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish. The Journal of biological chemistry. 285(52):41001-41009

Peng, C.A., Wang, C.H., and Wang, W.L. (2010) Rapid Antiviral Assay Using QD-tagged Fish Virus As Imaging Nanoprobe. Journal of virological methods. 169(2):412-415

Hu, S.Y., Lin, P.Y., Liao, C.H., Gong, H.Y., Lin, G.H., Kawakami, K., and Wu, J.L. (2010) Nitroreductase-mediated Gonadal Dysgenesis for Infertility Control of Genetically Modified Zebrafish. Marine biotechnology (New York, N.Y.). 12(5):569-578

Chen, L.C., Wu, J.L., Shiau, C.Y., and Chen, J.Y. (2010) Organization and promoter analysis of the zebrafish (Danio rerio) chemokine gene (CXC-64) promoter. Fish physiology and biochemistry. 36(3):511-521

Hsu, C.C., Hou, M.F., Hong, J.R., Wu, J.L., and Her, G.M. (2010) Inducible Male Infertility by Targeted Cell Ablation in Zebrafish Testis. Marine biotechnology (New York, N.Y.). 12(4):466-478

Chiu, C.L., Wu, J.L., Her, G.M., Chou, Y.L., and Hong, J.R. (2010) Aquatic birnavirus capsid protein, VP3, induces apoptosis via the Bad-mediated mitochondria pathway in fish and mouse cells. Apoptosis : an international journal on programmed cell death. 15(6):653-668

Chen, J.Y., Chiou, M.J., Chen, L.K., and Wu, J.L. (2010) Molecular cloning and functional analysis of the zebrafish follicle-stimulating hormone (FSH)beta promoter. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 155(2):155-163

Lee, C.Y., Hu, S.Y., Gong, H.Y., Chen, M.H., Lu, J.K., and Wu, J.L. (2009) Suppression of myostatin with vector-based RNA interference causes a double-muscle effect in transgenic zebrafish. Biochemical and Biophysical Research Communications. 387(4):766-771

Lin, S.B., Fan, T.W., Wu, J.L., Hui, C.F., and Chen, J.Y. (2009) Immune response and inhibition of bacterial growth by electrotransfer of plasmid DNA containing the antimicrobial peptide, epinecidin-1, into zebrafish muscle. Fish & shellfish immunology. 26(3):451-458

Hu, S.Y., Chen, M.H., Lin, Y.C., Lin, G.H., Gong, H.Y., and Wu, J.L. (2008) Cloning and functional analysis of the proximal promoter region of the three GnRH genes from the silver sea bream (Sparus sarba). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 151(4):373-380

Chen, L.C., Chen, J.Y., Hour, A.L., Shiau, C.Y., Hui, C.F., and Wu, J.L. (2008) Molecular cloning and functional analysis of zebrafish (Danio rerio) chemokine genes. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 151(4):400-409

Amali, A.A., Lin, C.J., Chen, Y.H., Wang, W.L., Gong, H.Y., Rekha, R.D., Lu, J.K., Chen, T.T., and Wu, J.L. (2008) Overexpression of Myostatin2 in zebrafish reduces the expression of dystrophin associated protein complex (DAPC) which leads to muscle dystrophy. Journal of Biomedical Science. 15(5):595-604

Pan, C.Y., Chen, J.Y., Ni, I.H., Wu, J.L., and Kuo, C.M. (2008) Organization and promoter analysis of the grouper (Epinephelus coioides) epinecidin-1 gene. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 150(4):358-367

Huang, W.T., Hsieh, J.C., Chiou, M.J., Chen, J.Y., Wu, J.L., and Kuo, C.M. (2008) Application of RNAi Technology to the Inhibition of Zebrafish GtHalpha, FSHbeta, and LHbeta Expression and to Functional Analyses. Zoological science. 25(6):614-621

Wu, H.C., Chiu, C.S., Wu, J.L., Gong, H.Y., Chen, M.C., Lu, M.W., and Hong, J.R. (2008) Zebrafish anti-apoptotic protein zfBcl-x(L) can block betanodavirus protein alpha-induced mitochondria-mediated secondary necrosis cell death. Fish & shellfish immunology. 24(4):436-449

Cheng, P.Y., Lin, C.C., Wu, C.S., Lu, Y.F., Lin, C.Y., Chung, C.C., Chu, C.Y, Huang, C.J., Tsai, C.Y., Korzh, S., Wu, J.L., and Hwang, S.P. (2008) Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation. Development (Cambridge, England). 135(5):941-952

Rekha, R.D., Amali, A.A., Her, G.M., Yeh, Y.H., Gong, H.Y., Hu, S.Y., Lin, G.H., and Wu, J.L. (2008) Thioacetamide accelerates steatohepatitis, cirrhosis and HCC by expressing HCV core protein in transgenic zebrafish Danio rerio. Toxicology. 243(1-2):11-22

Hu, M.C., Gong, H.Y., Lin, G.H., Hu, S.Y., Chen, M.H., Huang, S.J., Liao, C.F., and Wu, J.L. (2007) XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line. Biochemical and Biophysical Research Communications. 359(3):778-783

Ken, C.F., Lin, C.T., Wen, Y.D., and Wu, J.L. (2007) Replacement of Buried Cysteine from Zebrafish Cu/Zn Superoxide Dismutase and Enhancement of Its Stability via Site-Directed Mutagenesis. Marine biotechnology (New York, N.Y.). 9(3):335-342

Chou, M.J., Chen, J.C., Chen, J.Y., Gong, H.Y., Li, L.T., Huang, T.C., Wu, J.L., and Kuo, C.M. (2006) Isolation and characterization of the zebrafish Danio rerio insulin-like growth factor binding protein-3 promoter region. Fisheries science : FS. 74:153-166

Chiou, M.J., Chao, T.T., Wu, J.L., Kuo, C.M., and Chen, J.Y. (2006) The physiological role of CTGF/CCN2 in zebrafish notochond development and biological analysis of the proximal promoter region. Biochemical and Biophysical Research Communications. 349(2):750-758

Amali, A.A., Rekha, R.D., Lin, C.J., Wang, W.L., Gong, H.Y., Her, G.M., and Wu, J.L. (2006) Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis. Journal of Biomedical Science. 13(2):225-232

Her, G.M., Cheng, C.H., Hon, J.R., Sundaram, G.S., and Wu, J.L. (2006) Imbalance in liver homeostasis leading to hyperplasia by overexpressing either one of the Bcl-2-related genes, zfBLP1 and zfMcl-1a. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(2):515-523

Chen, J.Y., Chou, M.J., Gong, H.Y., Huang, T.C., Wu, J.L., and Kuo, C.M. (2005) Cloning and Biological Analysis of the Zebrafish (Danio rerio) Insulin-Like Growth Factor Binding Protein-2 Proximal Promoter Region. DNA and cell biology. 24(3):199-208

Hong, J.R., Lin, G.H., Lin, C.J., Wang, W.P., Lee, C.C., Lin, T.L., and Wu, J.L. (2004) Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. Development (Cambridge, England). 131(21):5417-5427

Gong, H.Y., Lin, C.J., Chen, M.H., Hu, M.C., Lin, G.H., Zhou, Y., Zon, L.I., and Wu, J.L. (2004) Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish. Gene. 338(1):35-46

Her, G.M., Yeh, Y.H., and Wu, J.L. (2004) Functional conserved elements mediate intestinal-type fatty acid binding protein (I-FABP) expression in the gut epithelia of zebrafish larvae. Developmental Dynamics : an official publication of the American Association of Anatomists. 230(4):734-742

Amali, A.A., Lin, C.J., Chen, Y.H., Wang, W.L., Gong, H.Y., Lee, C.Y., Ko, Y.L., Lu, J.K., Her, G.M., Chen, T.T., and Wu, J.L. (2004) Up-regulation of muscle-specific transcription factors during embryonic somitogenesis of zebrafish (Danio rerio) by knock-down of myostatin-1. Developmental Dynamics : an official publication of the American Association of Anatomists. 229(4):847-856

Her, G.M., Chiang, C.C., and Wu, J.L. (2004) Zebrafish intestinal fatty acid binding protein (I-FABP) gene promoter drives gut-specific expression in stable transgenic fish. Genesis (New York, N.Y. : 2000). 38(1):26-31

Chen, J.Y., Chen, J.C., Huang, W.T., Liu, C.W., Hui, C.F., Chen, T.T., and Wu, J.L. (2004) Molecular cloning and tissue-specific, developmental-stage-specific, and hormonal regulation of IGFBP3 gene in zebrafish. Marine biotechnology (New York, N.Y.). 6(1):1-7

Shentu, H., Wen, H.-J., Mour Her, G., Huang, C.-J., Wu, J.-L., and Hwang, S.-P. (2003) Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein. Genesis (New York, N.Y. : 2000). 37(3):103-112

Chen, J.Y., Chen, J.C., and Wu, J.L. (2003) Molecular cloning and functional analysis of zebrafish high-density lipoprotein-binding protein. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 136(1):117-130

Her, G.M., Yeh, Y-.H., and Wu, J.-L. (2003) 435-bp liver regulatory sequence in the liver fatty acid binding protein (L-FABP) gene is sufficient to modulate liver regional expression in transgenic zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 227(3):347-356

Her, G.-M., Chiang, C.-C., Chen, W.-Y., and Wu, J.-L. (2003) In vivo studies of liver-type fatty acid binding protein (L-FABP) gene expression in liver of transgenic zebrafish (Danio rerio). FEBS letters. 538(1-3):125-133

Cheng, R.S. and Wu, J.L. (2002) Gene expression of insulin-like growth factor-I receptor and p53 suppressor during zebrafish (Danio rerio) embryogenesis. Marine biotechnology (New York, N.Y.). 4(3):226-235

Huang, W.T., Gong, H.Y., Lin, C.J., Weng, C.F., Chen, M.H., and Wu, J.L. (2001) Hepatocyte nuclear factors-1alpha, -1beta, and -3beta expressed in the gonad of tilapia (Oreochromis mossambicus). Biochemical and Biophysical Research Communications. 288(4):833-840

Chen, J.-Y., Chang, B.-E., Chen, Y.-H., Lin, C.J.F., Wu, J.-L., and Kuo, C.-M. (2001) Molecular Cloning, Developmental Expression, and Hormonal Regulation of Zebrafish (Danio rerio) β Crystallin B1, a Member of the Superfamily of β Crystallin Proteins. Biochemical and Biophysical Research Communications. 285(1):105-110

Chen, J.-Y., Yang, J.-Y., Wang, J.-I., and Wu, J.-L. (2001) Introduction of green fluorescent protein and Lac-Z gene into zebrafish (Danio rerio) egg by microinjection and particle gun. J. Fish. Soc. Taiwan. 28(2):91-103

Chen, M., Gong, H., Cheng, C., Wang, J., Hong, J., and Wu, J. (2001) Cloning and characterization of zfBLP1, a Bcl-XL homologue from the zebrafish, Danio rerio. BBA Gene Structure and Expression. 1519(1-2):127-133

Chen, M.H., Lin, G., Gong, H., Weng, C., Chang, C., and Wu, J. (2001) The characterization of prepro-Insulin-like growth factor-1 Ea-2 expression and Insulin-like growth factor-1 genes (devoid 81 bp) in the zebrafish (Danio rerio). Gene. 268(1-2):67-75

Tsai, C.W., Tseng, J.J., Lin, S.C., Chang, C.Y., Wu, J.L., Horng, J.F., and Tsay, H.J. (2001) Primary structure and developmental expression of zebrafish sodium channel Nav1.6 during neurogenesis. DNA and cell biology. 20(5):249-255

Chen, M.C., Gong, H.Y., Cheng, C.Y., Wang, J.P., Hong, J.R., and Wu, J.L. (2000) Cloning and characterization of a novel nuclear Bcl-2 family protein, zfMcl-1a, in zebrafish embryo. Biochemical and Biophysical Research Communications. 279(2):725-731

Ken, C.-F., Lin, C.-T., Wu, J.-L., and Shaw, J.-F. (2000) Cloning and expression of a cDNA coding for catalase from zebrafish (Danio rerio). Journal of Agricultural and Food Chemistry. 48(6):2092-2096

NON-ZEBRAFISH PUBLICATIONS
1. Y. L. Yang., Y. S. Lin., J. L. Wu., C. F. Hui. Variation in mitochondrial DNA and population structure of the Taipei treefrog Rhdcophorus in Taiwan. Molecular Ecology, 1994 ; 3: 219-228.

2. Y. L. Hsu., C. C. Chen and J. L. Wu. Molecular relationships in infectious pancreatic necrosis virus. Virus Research, 1995 ; 37: 239-252.

3. Y .L. Hsu., Y. H. Yang, M. C. Tung, J. L. Wu., M. H. Engelking and J. C. Leong, Development of an in Vitro Subculture System for the Oka Organ (Lymphoid -Tissue) of Penaeus Monodon. Aquaculture, 1995; 136: 43-55.

4. J. G. Cheg., C. F. Liao, Y. L. Hsu and J. L. Wu. Expression of Homeobox-containing genes in common carp (Cyprinus carpio L.). Zoolocigal Studies, 1995;34:170-176.

5. H. C. Wu., C. Y. Chang and J. L. Wu . Detection of infectious pancreatic necrosis virus with radiolabeled and digoxigenin-labeled cDNA probes. Zoolocigal Studies, 1996; 35: 49-54.

6. S. H. Gu., Y. S. Chow., F. J. Lin., J. L. Wu., and R. J. Ho. A deficiency in prothoracicotropic hormone transduction pathway during the early last larval instar of Bombys mori.Molecular and Cellular Endocrinology, 1996 ;120: 99-105.

7. J. Y. Chen., C. Y. Chang, J. C. Chen, S.C. Shen and J. L. Wu. Production of biologically active recombinant tilapia insulin-like growth factor-II polypeptides in E.coli cells and characterization of the genomic structure of the coding region. DNA and Cell Biology, 1997;16:883-892.

8. S. M. Wu., P.P. Huang., C. L. Hew and J. L. Wu. Effect of Antifreeze Protein on Cold Tolerance in Juvenile Tilapia (Oreochromis mossambicus) and Milkfish (Chanos chanos Forsskal). Zoolocigal Studies, 1998; 37:39-44.

9. J. Y. Chen., H. L Tsia., C. Y. Chang., J. I. Wang., S. C. Shen and J. L. Wu. Isolation and Characterization of Tilapia ( Oreochromis mossambicus ) Insulin- Like Growth Factors Gene and Proximal Promoter Region. DNA and Cell Biology, 1998 ; 17 (4) : 359-376.

10. J. L Wu., J. R. Hong, C. Y. Chang., C. F. Hui., C. F. Liao and Y. L. Hsu. 1998. Involvement of Serine Proteinase in Infectious Pancreatic Necrosis Virus Capsid Protein Maturation and NS Proteinase Cleavage in CHSE-214 Cells. Journal of Fish Diseases, 1998 ;21:215-220.

11. Mark H. C. Chen., G. H. Lin., H. Y. Gong., C. Y. Lee., C. Y. Chang T. T. Chen and J. L. Wu . Cloning and characterization of insulin-like growth factor I cDNA from black seabream (Acathopagrus schlegeli). Zoolocigal Studies, 1998; 37(3): 213-221.

12. J. R. Hong., T. L. Lin, Y. L. Hsu and J. L. Wu. Apoptosis precedes necrosis of fish cell line with infectious pancreatic necrosis virus infection. Virology, 1998 ; 250:76-84.

13. H. W. Sun., C. F. Hui and J. L. Wu. Cloning, Characterization and Expression in Escherichia coli of Three Creatine Kinase Muscle Isoenzyme cDNAs from Carp ( Cyprinus carpio ) Striated Muscle. Journal of Biological Chemistry, 1998 ; 273: 33774 - 33780.

14. J. R. Hong., T. L. Lin., Y. L. Hsu and J. L. Wu. Induction of apoptosis and secondary necrosis by infectious pancreatic necrosis virus in fish embryonic cells. Journal of Fish Disease, 1998 ; 21, 463-467.

15. J. R. Hong., T. L. Lin., J. Y. Yang., Y. L. Hsu and J. L. Wu. Non-typical apoptotic morphological change in infectious pancreatic necrosis virus induced apoptosis when imaged by green fluorescent protein. Journal of Virology, 1999 ;73(6). 5056-5063.

16. J. R. Hong., Y. L. Hsu and J. L. Wu. Infectious pancreatic necrosis virus induce apoptosis due to down-regulation the surviral factor MCL-1 in fish cell line. Virus Research, 1999 : 63, 75-83.

17. H. Y. Chou., T. Y. Peng., S. J. Chang., Y. L. Hsu. and J. L. Wu. Effect of heavy metal stressors and salinity shock on the susceptibility of grouper ( epinephelus sp.) to infectious pancreatic necrosis virus (IPNV). Virus Research, 1999 : 63, 212-219.

18. K. K. Lee., T. I. Yang., P. C. Liu., J. L. Wu, and Y. L. Hsu. Dual challenges of infectious pancreatic necrosis virus and Vibrio carchariae in the grouper, Epinephelus sp.. Virus Research, 1999 : 63, 131-134.

19. J. Y. Chen., J. C. Chen., C. Y. Chang., S. C. Shen., M. S. Chen. and J. L. Wu. Expression of recombinant tilapia insulin-like growth factor-I and stimulation of juvenile tilapia growth by injuction of recombinant IDFs polypeptides. Aquaculture, 2000 : 181, 347-360.

20. J. Y. Chen., J. Y. Chen., H. N. Wu., W. G. Ju., T. L. Hsu and J. L. Wu. 2000. Infectious pancreatic necrosis virus RNA cleavage in vitro by hammerhead ribozymes and enhancement of bibozyme catalysis by oligonucleotide facllitators. Marine Biotechnology, 2000 : 2, 364-375.