ZFIN ID: ZDB-PERS-000327-2
Barrallo Gimeno, Alejandro
Email: abarrallo@ub.edu
Affiliation: Barrallo Gimeno Lab
Address: Departament de Ciències Fisiològiques Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona Pavelló de Govern. Campus de Bellvitge C. Feixa Llarga s/n 08907 L´Hospitalet de Llobregat Spain
Phone: +34934020836
ORCID ID: 0000-0003-2086-8926

I did my Ph.D. in the University of Salamanca (Spain) on the pharmacology of opioid receptors in the zebrafish. After 10 years of post-doc working on the neural crest and evolution, I moved to University of Barcelona. Here, we are using the zebrafish as a model for diseases related to ion fluxes in different tissues.

Pérez-Rius, C., Folgueira, M., Elorza-Vidal, X., Alia, A., Hoegg-Beiler, M.B., Eeza, M.N.H., Díaz, M.L., Nunes, V., Barrallo-Gimeno, A., Estévez, R. (2019) Comparison of zebrafish and mice knockouts for Megalencephalic Leukoencephalopathy proteins indicates that GlialCAM/MLC1 forms a functional unit. Orphanet journal of rare diseases. 14:268
Estévez, R., Elorza-Vidal, X., Gaitán-Peñas, H., Pérez-Rius, C., Armand-Ugón, M., Alonso-Gardón, M., Xicoy-Espaulella, E., Sirisi, S., Arnedo, T., Capdevila-Nortes, X., López-Hernández, T., Montolio, M., Duarri, A., Teijido, O., Barrallo-Gimeno, A., Palacín, M., Nunes, V. (2017) Megalencephalic leukoencephalopathy with subcortical cysts: A personal biochemical retrospective. European Journal of Medical Genetics. 61(1):50-60
Pérez-Rius, C., Gaitán-Peñas, H., Estévez, R., Barrallo-Gimeno, A. (2015) Identification and characterization of the zebrafish ClC-2 chloride channel orthologs. Pflugers Archiv : European journal of physiology. 467(8):1769-81
Sirisi, S., Folgueira, M., López-Hernández, T., Minieri, L., Pérez-Rius, C., Gaitán-Peñas, H., Zang, J., Martínez, A., Capdevila-Nortes, X., de la Villa, P., Roy, U., Alia, A., Neuhauss, S., Ferroni, S., Nunes, V., Estévez, R., Barrallo-Gimeno, A. (2014) Megalencephalic Leukoencephalopathy with subcortical Cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans. Human molecular genetics. 23(19):5069-86
Rodríguez-Aznar, E., Barrallo-Gimeno, A., and Nieto, M.A. (2013) Scratch2 Prevents Cell Cycle Re-Entry by Repressing miR-25 in Postmitotic Primary Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(12):5095-5105
Ocaña, O.H., Córcoles, R., Fabra, A., Moreno-Bueno, G., Acloque, H., Vega, S.,Barrallo-Gimeno, A., Cano, A., Nieto, M.A. (2012) Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1. Cancer Cell. 22(6):709-724
Sarmah, S., Barrallo-Gimeno, A., Melville, D.B., Topczewski, J., Solnica-Krezel, L., and Knapik, E.W. (2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 5(4):e10367
Blanco, M.J., Barrallo-Gimeno, A., Acloque, H., Reyes, A.E., Tada, M., Allende, M.L., Mayor, R., and Nieto, M.A. (2007) Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development (Cambridge, England). 134(22):4073-4081
Gonzalez-Nuñez, V., Barrallo, A., Traynor, J.R., and Rodriguez, R.E. (2006) Characterization of Opioid-Binding Sites in Zebrafish Brain. The Journal of pharmacology and experimental therapeutics. 316(2):900-904
Barrallo Gimeno, A., Holzschuh, J., Driever, W., and Knapik, E.W. (2004) Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Development (Cambridge, England). 131(7):1463-1477
Holzschuh, J., Barrallo Gimeno, A., Ettl, A.K., Durr, K., Knapik, E.W., and Driever, W. (2003) Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype. Development (Cambridge, England). 130(23):5741-5754
Barrallo, A., González Sarmiento, R., Alvar, F., and Rodriguez, R.E. (2000) ZFOR2, a new opioid receptor-like gene from the teleost zebrafish (Danio rerio). Brain research. Molecular brain research. 84(1-2):1-6
Rodriguez, R.E., Barrallo, A., Garcia Malvar, F., McFadyen, I.J., González Sarmiento, R., and Traynor, J.R. (2000) Characterization of ZFOR1, a putative delta-opioid receptor from the teleost zebrafish (Danio rerio). Neuroscience letters. 288(3):207-210
Porteros, A., García Isidoro, M., Barrallo, A., González Sarmiento, R., and Rodriguez, R.E. (1999) Expression of ZFOR1, a delta-opioid receptor, in the central nervous system of the zebrafish (Danio rerio). The Journal of comparative neurology. 412(3):429-438
Barrallo, A., González Sarmiento, R., García Isidoro, M., Cidad, P., Porteros, A., Rodriguez, R.E. (1999) Differential brain expression of a new ß-actin gene from zebrafish (Danio rerio). The European journal of neuroscience. 11:369-372
Barrallo, A., Malvar, F.G., and Traynor, J.R. (1998) Cloning and characterization of a delta opioid receptor from zebrafish. Trans. Biochem. Soc.. 26:S360
Barrallo, A., González Sarmiento, R., Porteros, A., García Isidoro, M., and Rodriguez, R.E. (1998) Cloning, molecular characterization, and distribution of a gene homologous to delta opioid receptor from zebrafish (Danio rerio). Biochemical and Biophysical Research Communications. 245:544-548

H. Gaitán-Peñas, A. Gradogna, L. Laparra-Cuervo, C. Solsona, V. Fernández-Dueñas, A. Barrallo-Gimeno, F. Ciruela, M. Lakadamyali, M. Pusch, R. Estévez. (2016) Investigation of LRRC8-Mediated Volume-Regulated Anion Currents in Xenopus Oocytes. Biophys J. 111:1429-1443.

X. Capdevila-Nortes, E. Jeworutzki, X. Elorza-Vidal, A. Barrallo-Gimeno, M. Pusch, R. Estévez (2015) Structural determinants of interaction, trafficking and function in the ClC-2/MLC1 subunit GlialCAM involved in leukodystrophy. J. Physiol. 593: 4165-4180.

A. Barrallo-Gimeno, A. Gradogna, I. Zanardi, M. Pusch, R. Estévez (2015). Regulatory-auxiliary subunits of CLC chloride channel –transport proteins. J. Physiol. 593: 4111-4127.

A. Barrallo-Gimeno, R. Estévez (2014). GLIALCAM, a glial cell adhesion molecule implicated in neurological disease. Adv. Neurobiol. 8:47-59.

A. Barrallo-Gimeno, M. A. Nieto (2009). Evolutionary history of the Snail/Scratch superfamily. Trends in Genetics 25: 248-252.

A. Barrallo-Gimeno, M. A. Nieto (2008). Riding the right wave: would the real neural crest please stand up? Evolution & Development 10: 509-510.

A. Barrallo-Gimeno, M.A. Nieto. (2006). Evolution of the neural crest. Adv Exp Med Biol. 589: 235-244.

A. Barrallo-Gimeno, M. A. Nieto. (2005). The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132: 3151-3161.