ZFIN Morpholino: MO2-six6b

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-six6b

No data available

Phenotype

Phenotype resulting from MO2-six6b

Phenotype	Fish	Figures
cranial nerve II decreased thickness, abnormal	WT + MO2-six6b	Fig. text only from Springelkamp et al., 2017 Fig. 2 from Iglesias et al., 2014
eye decreased size, abnormal	WT + MO2-six6b	Fig. text only from Springelkamp et al., 2017 Fig. 1, Fig. 2 from Iglesias et al., 2014
eye hypoplastic, abnormal	WT + MO2-six6b	Fig. 2 from Iglesias et al., 2014
eye immature, abnormal	WT + MO2-six6b	Fig. 2 from Iglesias et al., 2014
eye cdkn1a expression increased amount, abnormal	WT + MO2-six6b	Fig. 3 from Springelkamp et al., 2017

1 - 5 of 18 Show all

Phenotype of all Fish created by or utilizing MO2-six6b

Phenotype	Fish	Conditions	Figures
eye decreased size, abnormal	WT + MO2-six6b	standard conditions	Fig. text only from Springelkamp et al., 2017 Fig. 1, Fig. 2 from Iglesias et al., 2014
cranial nerve II decreased thickness, abnormal	WT + MO2-six6b	standard conditions	Fig. text only from Springelkamp et al., 2017 Fig. 2 from Iglesias et al., 2014
eye cdkn1a expression increased amount, abnormal	WT + MO2-six6b	standard conditions	Fig. 3 from Springelkamp et al., 2017
retina proliferative, abnormal	WT + MO2-six6b	standard conditions	Fig. 4 from Iglesias et al., 2014
retina layer formation delayed, abnormal	WT + MO2-six6b	standard conditions	Fig. 4 from Iglesias et al., 2014

1 - 5 of 24 Show all

Citations

Include unpublished citations

Springelkamp, H., Iglesias, A.I., Mishra, A., Höhn, R., Wojciechowski, R., Khawaja, A.P., Nag, A., Wang, Y.X., Wang, J.J., Cuellar-Partida, G., Gibson, J., Cooke Bailey, J.N., Vithana, E.N., Gharahkhani, P., Boutin, T., Ramdas, W.D., Zeller, T., Luben, R.N., Yonova-Doing, E., Viswanathan, A.C., Yazar, S., Cree, A.J., Haines, J.L., Koh, J.Y., Souzeau, E., Wilson, J.F., Amin, N., Müller, C., Venturini, C., Kearns, L.S., Hee Kang, J., Tham, Y.C., Zhou, T., van Leeuwen, E.M., Nickels, S., Sanfilippo, P., Liao, J., Linde, H.V., Zhao, W., van Koolwijk, L.M., Zheng, L., Rivadeneira, F., Baskaran, M., van der Lee, S.J., Perera, S., de Jong, P.T., Oostra, B.A., Uitterlinden, A.G., Fan, Q., Hofman, A., Shyong Tai, E., Vingerling, J.R., Sim, X., Wolfs, R.C., Teo, Y.Y., Lemij, H.G., Khor, C.C., Willemsen, R., Lackner, K.J., Aung, T., Jansonius, N.M., Montgomery, G., Wild, P.S., Young, T.L., Burdon, K.P., Hysi, P.G., Pasquale, L.R., Wong, T.Y., Klaver, C.C., Hewitt, A.W., Jonas, J.B., Mitchell, P., Lotery, A.J., Foster, P.J., Vitart, V., Pfeiffer, N., Craig, J.E., Mackey, D.A., Hammond, C.J., Wiggs, J.L., Cheng, C.Y., van Duijn, C.M., MacGregor, S. (2017) New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Human molecular genetics. 26(2):438-453
Iglesias, A.I., Springelkamp, H., Linde, H.V., Severijnen, L.A., Amin, N., Oostra, B., Kockx, C.E., van den Hout, M.C., van Ijcken, W.F., Hofman, A., Uitterlinden, A.G., Verdijk, R.M., Klaver, C.C., Willemsen, R., and van Duijn, C.M. (2014) Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age. Human molecular genetics. 23(5):1320-32

1 - 2 of 2

Show