ZFIN Morpholino: MO3-dpysl2b

Target Location

Genome Build: GRCz11Chromosome: 10

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-dpysl2b

No data available

Phenotype

Phenotype resulting from MO3-dpysl2b

Phenotype	Fish	Figures
anterior commissure anterior commissure morphogenesis decreased process quality, abnormal	RW + MO3-dpysl2b	Fig. 2, Fig. 5 from Li et al., 2024
anterior commissure axon decreased distribution, abnormal	RW + MO3-dpysl2b	Fig. 1, Fig. 2, Fig. 5, Fig. 6 from Guo et al., 2022
anterior commissure axon ab1-tuba labeling spatial pattern, abnormal	RW + MO3-dpysl2b	Fig. 2, Fig. 5 from Li et al., 2024 Fig. 1, Fig. 2, Fig. 5, Fig. 6 from Guo et al., 2022
branchiomotor neuron neuron migration disrupted, abnormal	rw0Tg + MO3-dpysl2b	Fig. 3 from Fiallos-Oliveros et al., 2020
CaP motoneuron mislocalised, abnormal	RW + MO3-dpysl2b	Fig. 2 from Suzuki et al., 2022

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Phenotype of all Fish created by or utilizing MO3-dpysl2b

Phenotype	Fish	Conditions	Figures
anterior commissure anterior commissure morphogenesis decreased process quality, abnormal	RW + MO3-dpysl2b	control	Fig. 2, Fig. 5 from Li et al., 2024
postoptic commissure posterior commissure morphogenesis decreased process quality, abnormal	RW + MO3-dpysl2b	control	Fig. 2, Fig. 5 from Li et al., 2024
CaP motoneuron mislocalised, abnormal	RW + MO3-dpysl2b	control	Fig. 2 from Suzuki et al., 2022
postoptic commissure axon ab1-tuba labeling spatial pattern, abnormal	RW + MO3-dpysl2b	control	Fig. 2, Fig. 5 from Li et al., 2024 Fig. 1, Fig. 2, Fig. 5, Fig. 6 from Guo et al., 2022
postoptic commissure axon decreased distribution, abnormal	RW + MO3-dpysl2b	control	Fig. 1, Fig. 2, Fig. 5, Fig. 6 from Guo et al., 2022

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Citations

Include unpublished citations

Li, S., Guo, Y., Takahashi, M., Suzuki, H., Kosaki, K., Ohshima, T. (2024) Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2. Developmental Neurobiology. 84(3):203-216
Guo, Y., Oliveros, C.F., Ohshima, T. (2022) CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain. Developmental Neurobiology. 82(6):533-544
Suzuki, H., Li, S., Tokutomi, T., Takeuchi, C., Takahashi, M., Yamada, M., Okuno, H., Miya, F., Takenouchi, T., Numabe, H., Kosaki, K., Ohshima, T. (2022) De novo non-synonymous DPYSL2 (CRMP2) variants in two patients with intellectual disabilities and documentation of functional relevance through zebrafish rescue and cellular transfection experiments. Human molecular genetics. 31(24):4173-4182
Fiallos-Oliveros, C., Ohshima, T. (2020) Dpysl2 (CRMP2) is required for the migration of facial branchiomotor neurons in the developing zebrafish embryo. The International journal of developmental biology. 64:479-484
Liu, Z.Z., Zhu, J., Wang, C.L., Wang, X., Han, Y.Y., Liu, L.Y., Xu, H.A. (2018) CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons. Neural Plasticity. 2018:8791304
Morimura, R., Nozawa, K., Tanaka, H., and Ohshima, T. (2013) Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. Developmental Neurobiology. 73(12):911-20
Tanaka, H., Morimura, R., and Ohshima, T. (2012) Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish. Developmental Biology. 370(2):223-236

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