ZFIN Morpholino: MO2-pls3

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-pls3

No data available

Phenotype

Phenotype resulting from MO2-pls3

Phenotype	Fish	Figures
bone mineralization disrupted, abnormal	zf195Tg + MO2-pls3	Fig. S9 from van Dijk et al., 2013
ceratobranchial cartilage absence of anatomical entity, abnormal	zf195Tg + MO2-pls3	Fig. 1 from Zhong et al., 2024
ceratobranchial cartilage absent, abnormal	zf195Tg + MO2-pls3	Fig. S8 from van Dijk et al., 2013
ceratobranchial cartilage EGFP expression spatial pattern, abnormal	zf195Tg + MO2-pls3	Fig. 1 from Zhong et al., 2024
ceratohyal cartilage decreased length, abnormal	zf195Tg + MO2-pls3	Fig. 1 from Zhong et al., 2024

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Phenotype of all Fish created by or utilizing MO2-pls3

Phenotype	Fish	Conditions	Figures
whole organism decreased length, abnormal	WT + MO2-pls3	control	Fig. 3 from Fédou et al., 2021
pronephric glomerulus pronephric podocyte wt1a expression spatial pattern, abnormal	WT + MO2-pls3	control	Fig. 3 from Fédou et al., 2021
heart edematous, abnormal	WT + MO2-pls3	standard conditions	Fig. S9 from van Dijk et al., 2013
pronephric distal early tubule slc12a3 expression spatial pattern, abnormal	WT + MO2-pls3	control	Fig. 3 from Fédou et al., 2021
pronephric proximal convoluted tubule slc20a1a expression spatial pattern, abnormal	WT + MO2-pls3	control	Fig. 3 from Fédou et al., 2021

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Citations

Include unpublished citations

Zhong, W., Neugebauer, J., Pathak, J.L., Li, X., Pals, G., Zillikens, M.C., Eekhoff, E.M.W., Bravenboer, N., Zhang, Q., Hammerschmidt, M., Wirth, B., Micha, D. (2024) Functional Insights in PLS3-Mediated Osteogenic Regulation. Cells. 13(17):
Fédou, C., Camus, M., Lescat, O., Feuillet, G., Mueller, I., Ross, B., Buléon, M., Neau, E., Alves, M., Goudounéche, D., Breuil, B., Boizard, F., Bardou, Q., Casemayou, A., Tack, I., Dreux, S., Batut, J., Blader, P., Burlet-Schiltz, O., Decramer, S., Wirth, B., Klein, J., Saulnier-Blache, J.S., Buffin-Meyer, B., Schanstra, J.P. (2021) Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies Plastin 3 as a protein involved in glomerular integrity. The Journal of pathology. 254(5):575-588
van Dijk, F.S., Zillikens, M.C., Micha, D., Riessland, M., Marcelis, C.L., de Die-Smulders, C.E., Milbradt, J., Franken, A.A., Harsevoort, A.J., Lichtenbelt, K.D., Pruijs, H.E., Rubio-Gozalbo, M.E., Zwertbroek, R., Moutaouakil, Y., Egthuijsen, J., Hammerschmidt, M., Bijman, R., Semeins, C.M., Bakker, A.D., Everts, V., Klein-Nulend, J., Campos-Obando, N., Hofman, A., te Meerman, G.J., Verkerk, A.J., Uitterlinden, A.G., Maugeri, A., Sistermans, E.A., Waisfisz, Q., Meijers-Heijboer, H., Wirth, B., Simon, M.E., and Pals, G. (2013) PLS3 mutations in X-linked osteoporosis with fractures. New. Engl. J. Med.. 369(16):1529-1536
Hao, L.T., Wolman, M., Granato, M., and Beattie, C.E. (2012) Survival motor neuron affects plastin 3 protein levels leading to motor defects. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(15):5074-5084

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