ZFIN Morpholino: MO1-pdgfrb

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-pdgfrb

No data available

Phenotype

Phenotype resulting from MO1-pdgfrb

Phenotype	Fish	Figures
intersegmental vessel decreased amount, abnormal	s843Tg + MO1-pdgfrb	Fig. 5 from Wiens et al., 2010

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Phenotype of all Fish created by or utilizing MO1-pdgfrb

Phenotype	Fish	Conditions	Figures
ventral wall of dorsal aorta hematopoietic stem cell myb expression amount, ameliorated	WT + MO1-pdgfrb	chemical treatment by environment: dimethyloxalylglycine	Fig. 2 from Lim et al., 2017
ventral wall of dorsal aorta hematopoietic stem cell runx1 expression amount, ameliorated	WT + MO1-pdgfrb	chemical treatment by environment: dimethyloxalylglycine	Fig. 2 from Lim et al., 2017
intersegmental vessel decreased amount, abnormal	s843Tg + MO1-pdgfrb	standard conditions	Fig. 5 from Wiens et al., 2010
ventral wall of dorsal aorta hematopoietic stem cell runx1 expression amount, ameliorated	WT + MO1-pdgfrb + MO2-vhl	control	Fig. 2 from Lim et al., 2017
ventral wall of dorsal aorta hematopoietic stem cell myb expression amount, ameliorated	WT + MO1-pdgfrb + MO2-vhl	control	Fig. 2 from Lim et al., 2017

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Citations

Include unpublished citations

Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467
Lim, S.E., Esain, V., Kwan, W., Theodore, L.N., Cortes, M., Frost, I.M., Liu, S.Y., North, T.E. (2017) HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Experimental hematology. 46:83-95.e6
French, C.R., Seshadri, S., Destefano, A.L., Fornage, M., Arnold, C.R., Gage, P.J., Skarie, J.M., Dobyns, W.B., Millen, K.J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D.J., Childs, S.J., Waskiewicz, A.J., Lehmann, O.J. (2014) Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J. Clin. Invest.. 124(11):4877-81
Wiens, K.M., Lee, H.L., Shimada, H., Metcalf, A.E., Chao, M.Y., and Lien, C.L. (2010) Platelet-derived growth factor receptor Beta is critical for zebrafish intersegmental vessel formation. PLoS One. 5(6):e11324

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