ZFIN Morpholino: MO1-pak1

Target Location

Genome Build: GRCz11Chromosome: 18

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-pak1

No data available

Phenotype

Phenotype resulting from MO1-pak1

Phenotype	Fish	Figures
ceratohyal cartilage kinked, abnormal	WT + MO1-pak1	Fig. S5 from Magini et al., 2014
convergent extension process quality, abnormal	WT + MO1-pak1	Fig. 4 from Magini et al., 2014
cranial cartilage malformed, abnormal	WT + MO1-pak1	Fig. S5 from Magini et al., 2014
eye decreased size, abnormal	WT + MO1-pak1	Fig. 4 from Lightcap et al., 2009
head decreased size, abnormal	WT + MO1-pak1	Fig. 4 from Lightcap et al., 2009

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Phenotype of all Fish created by or utilizing MO1-pak1

Phenotype	Fish	Conditions	Figures
convergent extension process quality, abnormal	WT + MO1-pak1	standard conditions	Fig. 4 from Magini et al., 2014
thymus pro-T cell rag1 expression decreased amount, abnormal	WT + MO1-pak1	standard conditions	Fig. 5 from Lu et al., 2020
post-vent region curved, abnormal	WT + MO1-pak1	standard conditions	Fig. 4 from Lightcap et al., 2009
ceratohyal cartilage kinked, abnormal	WT + MO1-pak1	standard conditions	Fig. S5 from Magini et al., 2014
head decreased size, abnormal	WT + MO1-pak1	standard conditions	Fig. 4 from Lightcap et al., 2009

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Citations

Include unpublished citations

Lu, X., Zhang, Y., Liu, F., Wang, L. (2020) Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis. Journal of immunology (Baltimore, Md. : 1950). 204(9):2447-2454
Jagadeeshan, S., Sagayaraj, R.V., Paneerselvan, N., Ghouse, S.S., Malathi, R. (2017) Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. Cell biology and toxicology. 33(1):41-56
Magini, P., Pippucci, T., Tsai, I.C., Coppola, S., Stellacci, E., Bartoletti-Stella, A., Turchetti, D., Graziano, C., Cenacchi, G., Neri, I., Cordelli, D.M., Marchiani, V., Bergamaschi, R., Gasparre, G., Neri, G., Mazzanti, L., Patrizi, A., Franzoni, E., Romeo, G., Bordo, D., Tartaglia, M., Katsanis, N., Seri, M. (2014) A mutation in PAK3 with a dual molecular effect deregulates the RAS/MAPK pathway and drives an X-linked syndromic phenotype. Human molecular genetics. 23(13):3607-17
Zou, J., Li, W.Q., Li, Q., Li, X.Q., Zhang, J.T., Liu, G.Q., Chen, J., Qiu, X.X., Tian, F.J., Wang, Z.Z., Zhu, N., Qin, Y.W., Shen, B., Liu, T.X., and Jing, Q. (2011) Two Functional MicroRNA-126s Repress a Novel Target Gene p21-Activated Kinase 1 to Regulate Vascular Integrity in Zebrafish. Circulation research. 108(2):201-209
Lightcap, C.M., Kari, G., Arias-Romero, L.E., Chernoff, J., Rodeck, U., and Williams, J.C. (2009) Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One. 4(6):e6025

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