ZFIN Morpholino: MO1-cyba

Target Location

Genome Build: GRCz11Chromosome: 18

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cyba

No data available

Phenotype

Phenotype resulting from MO1-cyba

No data available

Phenotype of all Fish created by or utilizing MO1-cyba

Phenotype	Fish	Conditions	Figures
whole organism decreased life span, exacerbated	AB/TL + MO1-cyba	bacterial treatment by injection: Salmonella enterica subsp. enterica serovar Typhimurium	Fig. 6 from Masud et al., 2019
neutrophil response to wounding process quality, abnormal	WT + MO1-cyba	amputation: caudal fin	Fig. 4 from Tauzin et al., 2014
neutrophil chemotaxis process quality, abnormal	WT + MO1-cyba	amputation: caudal fin	Fig. 4 from Tauzin et al., 2014
macrophage reactive oxygen species absent, abnormal	ump2Tg + MO1-cyba	bacterial treatment by injection: Salmonella enterica subsp. enterica serovar Typhimurium	Fig. 6 from Masud et al., 2019
neutrophil response to wounding process quality, abnormal	uwm4Tg + MO1-cyba	amputation: caudal fin	Fig. 4 from Tauzin et al., 2014

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Citations

Include unpublished citations

Forn-Cuní, G., Welvaarts, L., Stel, F.M., van den Hondel, C.J., Arentshorst, M., Ram, A., Meijer, A.H. (2022) Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis. Autophagy. 19(1):324-337
Prajsnar, T.K., Serba, J.J., Dekker, B.M., Gibson, J.F., Masud, S., Fleming, A., Johnston, S.A., Renshaw, S.A., Meijer, A.H. (2020) The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 17(4):888-902
Masud, S., Prajsnar, T.K., Torraca, V., Lamers, G.E.M., Benning, M., Van Der Vaart, M., Meijer, A.H. (2019) Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model. Autophagy. 15(5):796-812
Schoen, T.J., Rosowski, E.E., Knox, B.P., Bennin, D., Keller, N.P., Huttenlocher, A. (2019) Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish. Journal of Cell Science. 133(5):
Mendieta-Serrano, M.A., Mendez-Cruz, F.J., Antúnez-Mojica, M., Schnabel, D., Alvarez, L., Cárdenas, L., Lomelí, H., Ruiz-Santiesteban, J.A., Salas-Vidal, E. (2018) NADPH-Oxidase-derived reactive oxygen species are required for cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly. Free radical biology & medicine. 130:82-98
Tauzin, S., Starnes, T.W., Becker, F.B., Lam, P.Y., Huttenlocher, A. (2014) Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. The Journal of cell biology. 207:589-98
Yan, B., Han, P., Pan, L., Lu, W., Xiong, J., Zhang, M., Zhang, W., Li, L., Wen, Z. (2014) Il-1beta and Reactive Oxygen Species Differentially Regulate Neutrophil Directional Migration and Basal Random Motility in a Zebrafish Injury-Induced Inflammation Model. Journal of immunology (Baltimore, Md. : 1950). 192(12):5998-6008
Yang, C.T., Cambier, C.J., Davis, J.M., Hall, C.J., Crosier, P.S., and Ramakrishnan, L. (2012) Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host & Microbe. 12(3):301-312
Niethammer, P., Grabher, C., Look, A.T., and Mitchison, T.J. (2009) A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 459(7249):996-999

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