ZFIN Morpholino: MO1-upf1

Target Location

Genome Build: GRCz11Chromosome: 2

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-upf1

No data available

Phenotype

Phenotype resulting from MO1-upf1

Phenotype	Fish	Figures
brain necrotic, abnormal	WT + MO1-upf1	Fig. s1 from Anastasaki et al., 2011
central nervous system necrotic, abnormal	TU + MO1-upf1 + MO4-tp53	Fig. 2, Fig. S3 from Wittkopp et al., 2009
embryo development delayed, abnormal	WT + MO1-upf1	Fig. s1 from Anastasaki et al., 2011
extension disorganized, abnormal	TU + MO1-upf1 + MO4-tp53	Fig. 2, Fig. S3 from Wittkopp et al., 2009
eye development process quality, abnormal	TU + MO1-upf1	Fig. 2, Fig. S3 from Wittkopp et al., 2009

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Phenotype of all Fish created by or utilizing MO1-upf1

Phenotype	Fish	Conditions	Figures
mRNA splicing, via spliceosome decreased occurrence, abnormal	TL + MO1-upf1	standard conditions	Fig. 6 from Lei et al., 2017
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay increased process quality, abnormal	TL + MO1-upf1	standard conditions	Fig. 6 from Lei et al., 2017
whole organism atxn1b expression increased amount, abnormal	TL + MO1-upf1	standard conditions	Fig. 6 from Lei et al., 2017
whole organism mmp30 expression increased amount, abnormal	TL + MO1-upf1	standard conditions	Fig. 6 from Lei et al., 2017
somitogenesis process quality, abnormal	TU + MO1-upf1	standard conditions	Fig. 2 from Wittkopp et al., 2009

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Citations

Include unpublished citations

Rahmati, M., Chebli, J., Banote, R.K., Roselli, S., Agholme, L., Zetterberg, H., Abramsson, A. (2024) Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay. eNeuro. 11(6):
Xie, A., Ma, Z., Wang, J., Zhang, Y., Chen, Y., Yang, C., Chen, J., Peng, J. (2023) Upf3a but not Upf1 mediates the genetic compensation response induced by leg1 deleterious mutations in an H3K4me3-independent manner. Cell discovery. 9:6363
Ma, Z., Zhu, P., Shi, H., Guo, L., Zhang, Q., Chen, Y., Chen, S., Zhang, Z., Peng, J., Chen, J. (2019) PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Nature. 568(7751):259-263
Lei, L., Yan, S.Y., Yang, R., Chen, J.Y., Li, Y., Bu, Y., Chang, N., Zhou, Q., Zhu, X., Li, C.Y., Xiong, J.W. (2017) Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors. Nucleic acids research. 45(6):3422-3436
Longman, D., Hug, N., Keith, M., Anastasaki, C., Patton, E.E., Grimes, G., and Cáceres, J.F. (2013) DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic acids research. 41(17):8319-31
Anastasaki, C., Longman, D., Capper, A., Patton, E.E., and Cáceres, J.F. (2011) Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic acids research. 39(9):3686-3694
Wittkopp, N., Huntzinger, E., Weiler, C., Saulière, J., Schmidt, S., Sonawane, M., and Izaurralde, E. (2009) Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Molecular and cellular biology. 29(13):3517-3528

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