ZFIN Morpholino: MO3-spi1b

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-spi1b

No data available

Phenotype

Phenotype resulting from MO3-spi1b

Phenotype	Fish	Figures
macrophage differentiation disrupted, abnormal	WT + MO3-spi1b	Fig. 4 from Su et al., 2007
myeloid cell decreased amount, abnormal	WT + MO3-spi1b	Fig. 4 from Su et al., 2007

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Phenotype of all Fish created by or utilizing MO3-spi1b

Phenotype	Fish	Conditions	Figures
whole organism decreased life span, ameliorated	AB + MO3-spi1b	bacterial treatment by injection: Burkholderia cenocepacia	Fig. 1 from Mesureur et al., 2017
defense response to bacterium disrupted, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 3 from Clay et al., 2007
defense response to bacterium decreased occurrence, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 1 , Fig. 6 from Clay et al., 2008
whole organism lacks all parts of type macrophage, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 5 from Clay et al., 2007
macrophage absent, abnormal	WIK + MO2-spi1b + MO3-spi1b	bacterial treatment: Mycobacterium marinum	Fig. 6 from Clay et al., 2008

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Citations

Include unpublished citations

Liang, H., Li, M., Chen, J., Zhou, W., Xia, D., Ding, Q., Yang, Y., Zhang, Z., Ran, C., Zhou, Z. (2024) The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish. Microbiome. 12:244244
Nielson, J.A., Davis, J.M. (2023) Roles for Microglia in Cryptococcal Brain Dissemination in the Zebrafish Larva. Microbiology spectrum. 11(2):e0431522
Scherer, A.K., Blair, B.A., Park, J., Seman, B.G., Kelley, J.B., Wheeler, R.T. (2020) Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast. PLoS pathogens. 16:e1008414
Cambier, C.J., O'Leary, S.M., O'Sullivan, M.P., Keane, J., Ramakrishnan, L. (2017) Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages. Immunity. 47(3):552-565.e4
Madigan, C.A., Cambier, C.J., Kelly-Scumpia, K.M., Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A., Modlin, R.L., Ramakrishnan, L. (2017) A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy. Cell. 170:973-985.e10
Mesureur, J., Feliciano, J.R., Wagner, N., Gomes, M.C., Zhang, L., Blanco-Gonzalez, M., van der Vaart, M., O'Callaghan, D., Meijer, A.H., Vergunst, A.C. (2017) Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS pathogens. 13:e1006437
Halloum, I., Carrère-Kremer, S., Blaise, M., Viljoen, A., Bernut, A., Le Moigne, V., Vilchèze, C., Guérardel, Y., Lutfalla, G., Herrmann, J.L., Jacobs, W.R., Kremer, L. (2016) Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent. Proceedings of the National Academy of Sciences of the United States of America. 113(29):E4228-37
Willis, A.R., Moore, C., Mazon-Moya, M., Krokowski, S., Lambert, C., Till, R., Mostowy, S., Sockett, R.E. (2016) Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae. Current biology : CB. 26(24):3343-3351
Belon, C., Soscia, C., Bernut, A., Laubier, A., Bleves, S., Blanc-Potard, A.B. (2015) A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens. PLoS pathogens. 11:e1004969
Bernut, A., Dupont, C., Sahuquet, A., Herrmann, J.L., Lutfalla, G., Kremer, L. (2015) Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos. Journal of visualized experiments : JoVE. (103):e53130

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