ZFIN Morpholino: MO1-htt

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-htt

No data available

Phenotype

Phenotype resulting from MO1-htt

Phenotype	Fish	Figures
apoptotic process decreased occurrence, abnormal	WT + MO1-htt	Fig. 1 from Henshall et al., 2009
apoptotic process increased occurrence, abnormal	AB + MO1-htt	Fig. 2 from Diekmann et al., 2009
blood low saturation, abnormal	WT + MO1-htt	Fig. 2, Fig. 3 from Lumsden et al., 2007
brain apoptotic, abnormal	AB + MO1-htt	Fig. 2 from Diekmann et al., 2009
brain necrotic, abnormal	WT + MO1-htt	Fig. 2, text only from Lumsden et al., 2007

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Phenotype of all Fish created by or utilizing MO1-htt

Phenotype	Fish	Conditions	Figures
pharyngeal arch 1 mislocalised ventrally, abnormal	AB + MO1-htt	standard conditions	Fig. 2 from Diekmann et al., 2009
post-vent region curved dorsal, abnormal	AB + MO1-htt	standard conditions	Fig. 5 from Diekmann et al., 2009
neural tube neuroepithelial cell disorganized, abnormal	AB + MO1-htt	standard conditions	Fig. S5 from Lo Sardo et al., 2012
ventricular system increased size, abnormal	AB + MO1-htt	standard conditions	Fig. 1 from Diekmann et al., 2009
apoptotic process increased occurrence, abnormal	AB + MO1-htt	standard conditions	Fig. 2 from Diekmann et al., 2009

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Citations

Include unpublished citations

Conforti, P., Zuccato, C., Gaudenzi, G., Ieraci, A., Camnasio, S., Buckley, N.J., Mutti, C., Cotelli, F., Contini, A., and Cattaneo, E. (2013) Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models. Journal of neurochemistry. 127(1):22-35
Lo Sardo, V., Zuccato, C., Gaudenzi, G., Vitali, B., Ramos, C., Tartari, M., Myre, M.A., Walker, J.A., Pistocchi, A., Conti, L., Valenza, M., Drung, B., Schmidt, B., Gusella, J., Zeitlin, S., Cotelli, F., and Cattaneo, E. (2012) An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin. Nature Neuroscience. 15(5):713-721
Diekmann, H., Anichtchik, O., Fleming, A., Futter, M., Goldsmith, P., Roach, A., and Rubinsztein, D.C. (2009) Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(5):1343-1349
Futter, M., Diekmann, H., Schoenmakers, E., Sadiq, O., Chatterjee, K., and Rubinsztein, D.C. (2009) Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors. Journal of Medical Genetics. 46(7):438-446
Henshall, T.L., Tucker, B., Lumsden, A.L., Nornes, S., Lardelli, M.T., and Richards, R.I. (2009) Selective neuronal requirement for Huntingtin in the developing zebrafish. Human molecular genetics. 18(24):4830-4842
Lumsden, A.L., Henshall, T.L., Dayan, S., Lardelli, M.T., and Richards, R.I. (2007) Huntingtin-deficient zebrafish exhibit defects in iron utilization and development. Human molecular genetics. 16(16):1905-1920

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