ZFIN Morpholino: MO1-aplnrb

Target Location

Genome Build: GRCz11Chromosome: 10

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-aplnrb

No data available

Phenotype

Phenotype resulting from MO1-aplnrb

Phenotype	Fish	Figures
angioblast cell migration from lateral mesoderm to midline process quality, abnormal	y1Tg + MO1-aplnrb	Fig. 2 from Helker et al., 2015
angiogenic sprout decreased length, abnormal	WT + MO1-aplnrb	Figure 2 from Helker et al., 2020
determination of heart left/right asymmetry process quality, abnormal	twu34Tg + MO1-aplnrb	Fig. 1 from Zhu et al., 2019
determination of left/right asymmetry in lateral mesoderm decreased occurrence, abnormal	AB + MO1-aplnrb	Fig. 2 from Zhu et al., 2019
determination of liver left/right asymmetry decreased occurrence, abnormal	AB + MO1-aplnrb	Fig. 1 from Zhu et al., 2019

1 - 5 of 19 Show all

Phenotype of all Fish created by or utilizing MO1-aplnrb

Phenotype	Fish	Conditions	Figures
lateral plate mesoderm spaw expression absent, abnormal	AB + MO1-aplnrb	standard conditions	Fig. 1 , Fig. 2 from Zhu et al., 2019
telencephalon determination of left/right asymmetry in nervous system decreased process quality, abnormal	AB + MO1-aplnrb	standard conditions	Fig. 1 from Zhu et al., 2019
telencephalon otx5 expression increased distribution, abnormal	AB + MO1-aplnrb	standard conditions	Fig. 1 from Zhu et al., 2019
lateral plate mesoderm right side spaw expression mislocalised, abnormal	AB + MO1-aplnrb	standard conditions	Fig. 2 from Zhu et al., 2019
determination of liver left/right asymmetry process quality, abnormal	AB + MO1-aplnrb	standard conditions	Fig. 1 from Zhu et al., 2019

1 - 5 of 39 Show all

Citations

Include unpublished citations

Stock, J., Kazmar, T., Schlumm, F., Hannezo, E., Pauli, A. (2022) A self-generated Toddler gradient guides mesodermal cell migration. Science advances. 8:eadd2488
Helker, C.S., Eberlein, J., Wilhelm, K., Sugino, T., Malchow, J., Schuermann, A., Baumeister, S., Kwon, H.B., Maischein, H.M., Potente, M., Herzog, W., Stainier, D.Y. (2020) Apelin signaling drives vascular endothelial cells towards a pro-angiogenic state. eLIFE. 9:e55589
Zhu, C., Guo, Z., Zhang, Y., Liu, M., Chen, B., Cao, K., Wu, Y., Yang, M., Yin, W., Zhao, H., Tai, H., Ou, Y., Yu, X., Liu, C., Li, S., Su, B., Feng, Y., Huang, S. (2019) Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms. International journal of biological sciences. 15:1225-1239
Liu, Z., Woo, S., Weiner, O.D. (2018) Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation. Development (Cambridge, England). 145(17):
Helker, C.S., Schuermann, A., Pollmann, C., Chng, S.C., Kiefer, F., Reversade, B., Herzog, W. (2015) The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis. eLIFE. 4
Pauli, A., Norris, M.L., Valen, E., Chew, G.L., Gagnon, J.A., Zimmerman, S., Mitchell, A., Ma, J., Dubrulle, J., Reyon, D., Tsai, S.Q., Joung, J.K., Saghatelian, A., and Schier, A.F. (2014) Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science (New York, N.Y.). 343(6172):1248636
Chng, S.C., Ho, L., Tian, J., and Reversade, B. (2013) ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor. Developmental Cell. 27(6):672-680
Zeng, X.X., Wilm, T.P., Sepich, D.S., and Solnica-Krezel, L. (2007) Apelin and Its Receptor Control Heart Field Formation during Zebrafish Gastrulation. Developmental Cell. 12(3):391-402

1 - 8 of 8

Show