ZFIN Morpholino: MO3-tfap2a

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-tfap2a

No data available

Phenotype

Phenotype resulting from MO3-tfap2a

Phenotype	Fish	Figures
anterior catecholaminergic tract decreased size, abnormal	WT + MO3-tfap2a	Fig. 4 from Kastenhuber et al., 2010
locus coeruleus adrenergic neuron absent, abnormal	WT + MO3-tfap2a	Fig. 4 from Kastenhuber et al., 2010
mandibular arch skeleton malformed, abnormal	ir937Tg + MO3-tfap2a	Fig. 5 from Hoffman et al., 2007
medulla oblongata adrenergic neuron absent, abnormal	WT + MO3-tfap2a	Fig. 4 from Kastenhuber et al., 2010

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Phenotype of all Fish created by or utilizing MO3-tfap2a

Phenotype	Fish	Conditions	Figures
medulla oblongata adrenergic neuron absent, abnormal	WT + MO3-tfap2a	standard conditions	Fig. 4 from Kastenhuber et al., 2010
anterior catecholaminergic tract decreased size, abnormal	WT + MO3-tfap2a	standard conditions	Fig. 4 from Kastenhuber et al., 2010
locus coeruleus adrenergic neuron absent, abnormal	WT + MO3-tfap2a	standard conditions	Fig. 4 from Kastenhuber et al., 2010
mandibular arch skeleton malformed, abnormal	ir937Tg + MO3-tfap2a	standard conditions	Fig. 5 from Hoffman et al., 2007
whole organism lacks all parts of type neural crest cell, abnormal	WT + MO1-tfap2c + MO3-tfap2a	standard conditions	Fig. S3 from Zhou et al., 2011

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Citations

Include unpublished citations

Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467
Ando, K., Fukuhara, S., Izumi, N., Nakajima, H., Fukui, H., Kelsh, R.N., Mochizuki, N. (2016) Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish. Development (Cambridge, England). 143(8):1328-39
Whitesell, T.R., Kennedy, R.M., Carter, A.D., Rollins, E.L., Georgijevic, S., Santoro, M.M., Childs, S.J. (2014) An alpha-smooth muscle actin (acta2/alphasma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells. PLoS One. 9:e90590
Powell, D.R., Hernandez-Lagunas, L., Lamonica, K., and Artinger, K.B. (2013) Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification. Development (Cambridge, England). 140(16):3445-3455
Knight, R.D., Mebus, K., d'Angelo, A., Yokoya, K., Heanue, T., and Roehl, H. (2011) Ret signalling integrates a craniofacial muscle module during development. Development (Cambridge, England). 138(10):2015-2024
Wang, W.D., Melville, D.B., Montero-Balaguer, M., Hatzopoulos, A.K., and Knapik, E.W. (2011) Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Developmental Biology. 360(1):173-85
Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8
Kastenhuber, E., Kratochwil, C.F., Ryu, S., Schweitzer, J., and Driever, W. (2010) Genetic dissection of dopaminergic and noradrenergic contributions to catecholaminergic tracts in early larval zebrafish. The Journal of comparative neurology. 518(4):439-458
Kastenhuber, E., Kern U., Bonkowsky, J.L., Chien, C.B., Driever, W., and Schweitzer, J. (2009) Netrin-DCC, Robo-Slit, and heparan sulfate proteoglycans coordinate lateral positioning of longitudinal dopaminergic diencephalospinal axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(28):8914-8926
Hoffman, T.L., Javier, A.L., Campeau, S.A., Knight, R.D., and Schilling, T.F. (2007) Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):679-691

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