ZFIN Morpholino: MO1-cyp11a1.1

Target Location

Genome Build: GRCz11Chromosome: 25

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cyp11a1.1

No data available

Phenotype

Phenotype resulting from MO1-cyp11a1.1

Phenotype	Fish	Figures
axis decreased length, abnormal	WT + MO1-cyp11a1.1	Fig. 3 from Hsu et al., 2006 Fig. 2, Fig. S2 from Hsu et al., 2006
epiboly arrested, abnormal	AB + MO1-cyp11a1.1	Fig. 3 from Parajes et al., 2013
epiboly involved in gastrulation with mouth forming second delayed, abnormal	WT + MO1-cyp11a1.1	Fig. 6 from Weng et al., 2013 Fig. 2, Fig. S2 from Hsu et al., 2006
epiboly involved in gastrulation with mouth forming second disrupted, abnormal	WT + MO1-cyp11a1.1	Fig. 3 from Hsu et al., 2006
extension decreased length, abnormal	WT + MO1-cyp11a1.1	Fig. 3 from Hsu et al., 2006

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Phenotype of all Fish created by or utilizing MO1-cyp11a1.1

Phenotype	Fish	Conditions	Figures
whole organism dead, abnormal	AB + MO1-cyp11a1.1	standard conditions	Fig. 3 from Parajes et al., 2013
epiboly arrested, abnormal	AB + MO1-cyp11a1.1	standard conditions	Fig. 3 from Parajes et al., 2013
epiboly involved in gastrulation with mouth forming second delayed, abnormal	TL + MO1-cyp11a1.1	standard conditions	Fig. 6 from Weng et al., 2013
epiboly involved in gastrulation with mouth forming second disrupted, abnormal	WT + MO1-cyp11a1.1	standard conditions	Fig. 3 from Hsu et al., 2006
axis decreased length, abnormal	WT + MO1-cyp11a1.1	standard conditions	Fig. 3 from Hsu et al., 2006 Fig. 2, Fig. S2 from Hsu et al., 2006

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Citations

Include unpublished citations

Li, Y., Li, X., Ye, D., Zhang, R., Liu, C., He, M., Wang, H., Hu, W., Sun, Y. (2024) Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zoological research. 45:176188176-188
Eckerle, S., Ringler, M., Lecaudey, V., Nitschke, R., Driever, W. (2017) Progesterone modulates microtubule dynamics and epiboly progression during zebrafish gastrulation. Developmental Biology. 434(2):249-266
Parajes, S., Griffin, A., Taylor, A.E., Rose, I.T., Miguel-Escalada, I., Hadzhiev, Y., Arlt, W., Shackleton, C., Muller, F., and Krone, N. (2013) Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme Cyp11a2. Endocrinology. 154(8):2702-11
Weng, J.H., Liang, M.R., Chen, C.H., Tong, S.K., Huang, T.C., Lee, S.P., Chen, Y.R., Chen, C.T., and Chung, B.C. (2013) Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration. Nature Chemical Biology. 9(10):636-42
Hsu, H.J., Hsu, N.C., Hu, M.C., and Chung, B.C. (2006) Steroidogenesis in zebrafish and mouse models. Molecular and Cellular Endocrinology. 248(1-2):160-163
Hsu, H.J., Liang, M.R., Chen, C.T., and Chung, B.C. (2006) Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement. Nature. 439(7075):480-483

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