ZFIN Morpholino: MO1-spaw

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-spaw

No data available

Phenotype

Phenotype resulting from MO1-spaw

Phenotype	Fish	Figures
cardioblast migration decreased process quality, abnormal	md3Tg; y1Tg + MO1-spaw	Fig. 3 from Veerkamp et al., 2013
cell migration involved in heart jogging decreased process quality, abnormal	md3Tg; y1Tg + MO1-spaw	Fig. 3 from Veerkamp et al., 2013
determination of heart left/right asymmetry decreased process quality, abnormal	twu34Tg + MO1-spaw	Fig. 4 from Veerkamp et al., 2013
determination of heart left/right asymmetry process quality, abnormal	WT + MO1-spaw	Fig. 5 from Long et al., 2003
determination of intestine left/right asymmetry disrupted, abnormal	pd24Tg + MO1-spaw	Fig. 1 from Yin et al., 2010

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Phenotype of all Fish created by or utilizing MO1-spaw

Phenotype	Fish	Conditions	Figures
lateral plate mesoderm pitx2 expression absent, abnormal	WT + MO1-spaw	standard conditions	Fig. 2 from Wang et al., 2008
heart development decreased process quality, abnormal	WT + MO1-spaw	standard conditions	Fig. 1 from Veerkamp et al., 2013
heart jogging process quality, abnormal	WT + MO1-spaw	standard conditions	Fig. 5 from Long et al., 2003
determination of left/right symmetry disrupted, abnormal	WT + MO1-spaw	standard conditions	Fig. 2 from Carl et al., 2007
habenula determination of left/right symmetry disrupted, abnormal	WT + MO1-spaw	standard conditions	Fig. 5 from Roussigné et al., 2009

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Citations

Include unpublished citations

Lombardo, V.A., Heise, M., Moghtadaei, M., Bornhorst, D., Männer, J., Abdelilah-Seyfried, S. (2019) Morphogenetic control of zebrafish cardiac looping by Bmp signaling. Development (Cambridge, England). 146(22):
Roussigné, M., Wei, L., Tsingos, E., Kuchling, F., Alkobtawi, M., Tsalavouta, M., Wittbrodt, J., Carl, M., Blader, P., Wilson, S.W. (2018) Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells. Proceedings of the National Academy of Sciences of the United States of America. 115(42):E9812-E9821
Facchin, L., Duboué, E.R., Halpern, M.E. (2015) Disruption of Epithalamic Left-Right Asymmetry Increases Anxiety in Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:15847-59
Nash, D., Arrington, C.B., Kennedy, B.J., Yandell, M., Wu, W., Zhang, W., Ware, S., Jorde, L.B., Gruber, P.J., Yost, H.J., Bowles, N.E., Bleyl, S.B. (2015) Shared Segment Analysis and Next-Generation Sequencing Implicates the Retinoic Acid Signaling Pathway in Total Anomalous Pulmonary Venous Return (TAPVR). PLoS One. 10:e0131514
Colombo, A., Palma, K., Armijo, L., Mione, M., Signore, I.A., Morales, C., Guerrero, N., Meynard, M.M., Pérez, R., Suazo, J., Marcelain, K., Briones, L., Härtel, S., Wilson, S.W., and Concha, M.L. (2013) Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Development (Cambridge, England). 140(19):3997-4007
Peterson, A.G., Wang, X., and Yost, H. J. (2013) Dvr1 transfers left-right asymmetric signals from Kupffer's vesicle to lateral plate mesoderm in zebrafish. Developmental Biology. 382(1):198-208
Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L., and Abdelilah-Seyfried, S. (2013) Unilateral dampening of bmp activity by nodal generates cardiac left-right asymmetry. Developmental Cell. 24(6):660-667
Huang, S., Ma, J., Liu, X., Zhang, Y., and Luo, L. (2011) Retinoic acid signaling sequentially controls visceral and heart laterality in Zebrafish. The Journal of biological chemistry. 286(32):28533-43
Yin, C., Kikuchi, K., Hochgreb, T., Poss, K.D., and Stainier, D.Y. (2010) Hand2 Regulates Extracellular Matrix Remodeling Essential for Gut-Looping Morphogenesis in Zebrafish. Developmental Cell. 18(6):973-984
Lin, X., and Xu, X. (2009) Distinct functions of Wnt/{beta}-catenin signaling in KV development and cardiac asymmetry. Development (Cambridge, England). 136(2):207-217

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