ZFIN Morpholino: MO1-ahr1a

Target Location

Genome Build: GRCz11Chromosome: 16

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ahr1a

No data available

Phenotype

Phenotype resulting from MO1-ahr1a

No data available

Phenotype of all Fish created by or utilizing MO1-ahr1a

Phenotype	Fish	Conditions	Figures
whole organism cyp1c1 expression increased amount, abnormal	EKW + MO1-ahr1a	chemical treatment by environment: 3,3',4,4',5-pentachlorobiphenyl	Fig. 6 from Garner et al., 2013
pericardium morphology, ameliorated	EKW + MO1-ahr1a	chemical treatment by environment: benzo[a]pyrene, chemical treatment by environment: fluoranthene	Fig. 7 from Garner et al., 2013
whole organism cyp1b1 expression increased amount, abnormal	EKW + MO1-ahr1a	chemical treatment by environment: 3,3',4,4',5-pentachlorobiphenyl	Fig. 6 from Garner et al., 2013
whole organism cyp1b1 expression increased amount, abnormal	EKW + MO1-ahr1a	chemical treatment by environment: benzo[a]pyrene, chemical treatment by environment: fluoranthene	Fig. 4 from Garner et al., 2013
pericardium morphology, exacerbated	EKW + MO1-ahr1a	chemical treatment by environment: Benzo[k]fluoranthene, chemical treatment by environment: fluoranthene	Fig. 1, Fig. 2 from Garner et al., 2013

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Citations

Include unpublished citations

Garland, M.A., Geier, M.C., Bugel, S.M., Shankar, P., Dunham, C.L., Brown, J.M., Tilton, S.C., Tanguay, R.L. (2020) Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicological sciences : an official journal of the Society of Toxicology. 176(1):46-64
Geier, M.C., James Minick, D., Truong, L., Tilton, S., Pande, P., Anderson, K.A., Teeguardan, J., Tanguay, R.L. (2018) Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicology and applied pharmacology. 354:115-125
Chlebowski, A.C., Garcia, G.R., La Du, J.K., Bisson, W.H., Truong, L., Massey Simonich, S.L., Tanguay, R.L. (2017) Mechanistic Investigations Into the Developmental Toxicity of Nitrated and Heterocyclic PAHs. Toxicological sciences : an official journal of the Society of Toxicology. 157:246-259
Gerlach, C.V., Das, S.R., Volz, D.C., Bisson, W.H., Kolluri, S.K., Tanguay, R.L. (2014) Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is an AHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 154C:71-79
Garner, L.V., Brown, D.R., and Di Giulio, R.T. (2013) Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Aquatic toxicology (Amsterdam, Netherlands). 142-143:336-346
Knecht, A.L., Goodale, B.C., Truong, L., Simonich, M.T., Swanson, A.J., Matzke, M.M., Anderson, K.A., Waters, K.M., and Tanguay, R.L. (2013) Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicology and applied pharmacology. 271(2):266-75
Goodale, B.C., La Du, J.K., Bisson, W.H., Janszen, D.B., Waters, K.M., and Tanguay, R.L. (2012) AHR2 Mutant Reveals Functional Diversity of Aryl Hydrocarbon Receptors in Zebrafish. PLoS One. 7(1):e29346
Incardona, J.P., Day, H.L., Collier, T.K., and Scholz, N.L. (2006) Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism. Toxicology and applied pharmacology. 217(3):308-321
Incardona, J.P., Carls, M.G., Teraoka, H., Sloan, C.A., Collier, T.K., and Scholz, N.L. (2005) Aryl Hydrocarbon Receptor-Independent Toxicity of Weathered Crude Oil during Fish Development. Environmental health perspectives. 113(12):1755-1762

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