ZFIN Morpholino: MO2-vegfaa

Target Location

Genome Build: GRCz11Chromosome: 16

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-vegfaa

No data available

Phenotype

Phenotype resulting from MO2-vegfaa

Phenotype	Fish	Figures
caudal vein plexus morphology, abnormal	y1Tg + MO2-vegfaa	Fig. S2 from Jia et al., 2013
intersegmental vessel aplastic, abnormal	y1Tg + MO2-vegfaa	Fig. 3 , Fig. 5 from Christie et al., 2010
intersegmental vessel decreased amount, abnormal	WT + MO2-vegfaa	Fig. 5 from De Angelis et al., 2017
intersegmental vessel immature, abnormal	y1Tg + MO2-vegfaa	Fig. S2 from Jia et al., 2013
pericardium edematous, abnormal	y1Tg + MO2-vegfaa	Fig. S2 from Jia et al., 2013

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Phenotype of all Fish created by or utilizing MO2-vegfaa

Phenotype	Fish	Conditions	Figures
intersegmental vessel decreased amount, abnormal	WT + MO2-vegfaa	standard conditions	Fig. 5 from De Angelis et al., 2017
intersegmental vessel immature, abnormal	y1Tg + MO2-vegfaa	standard conditions	Fig. S2 from Jia et al., 2013
caudal vein plexus morphology, abnormal	y1Tg + MO2-vegfaa	standard conditions	Fig. S2 from Jia et al., 2013
intersegmental vessel aplastic, abnormal	y1Tg + MO2-vegfaa	standard conditions	Fig. 3 , Fig. 5 from Christie et al., 2010
pericardium edematous, abnormal	y1Tg + MO2-vegfaa	standard conditions	Fig. S2 from Jia et al., 2013

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Citations

Include unpublished citations

Zhang, F., Zeng, Q.Y., Xu, H., Xu, A.N., Liu, D.J., Li, N.Z., Chen, Y., Jin, Y., Xu, C.H., Feng, C.Z., Zhang, Y.L., Liu, D., Liu, N., Xie, Y.Y., Yu, S.H., Yuan, H., Xue, K., Shi, J.Y., Liu, T.X., Xu, P.F., Zhao, W.L., Zhou, Y., Wang, L., Huang, Q.H., Chen, Z., Chen, S.J., Zhou, X.L., Sun, X.J. (2021) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell discovery. 7:98
De Angelis, J.E., Lagendijk, A.K., Chen, H., Tromp, A., Bower, N.I., Tunny, K.A., Brooks, A.J., Bakkers, J., Francois, M., Yap, A.S., Simons, C., Wicking, C., Hogan, B.M., Smith, K.A. (2017) Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. Developmental Cell. 40:123-136
Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97
Kuroyanagi, J., Shimada, Y., Zhang, B., Ariyoshi, M., Umemoto, N., Nishimura, Y., Tanaka, T. (2014) Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression. FEBS letters. 588(18):3409-16
Jia, D., Hasso, S.M., Chan, J., Filingeri, D., D'Amore, P.A., Rice, L., Pampo, C., Siemann, D.W., Zurakowski, D., Rodig, S.J., and Moses, M.A. (2013) Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo. Blood. 121(4):707-715
Christie, T.L., Carter, A., Rollins, E.L., and Childs, S.J. (2010) Syk and Zap-70 function redundantly to promote angioblast migration. Developmental Biology. 340(1):22-29
Lemmens, R., Van Hoecke, A., Hersmus, N., Geelen, V., D'Hollander, I., Thijs, V., Van Den Bosch, L., Carmeliet, P., and Robberecht, W. (2007) Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish. Human molecular genetics. 16(19):2359-2365
Alt, B., Elsalini, O.A., Schrumpf, P., Haufs, N., Lawson, N.D., Schwabe, G.C., Mundlos, S., Gruters, A., Krude, H., and Rohr, K.B. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development (Cambridge, England). 133(19):3797-3804
Larson, J.D., Wadman, S.A., Chen, E., Kerley, L., Clark, K.J., Eide, M., Lippert, S., Nasevicius, A., Ekker, S.C., Hackett, P.B., and Essner, J.J. (2004) Expression of VE-cadherin in zebrafish embryos: A new tool to evaluate vascular development. Developmental Dynamics : an official publication of the American Association of Anatomists. 231(1):204-213
Nasevicius, A., Larson, J., and Ekker, S.C. (2000) Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant. Yeast (Chichester, England). 17(4):294-301

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