ZFIN Morpholino: MO1-wnt3a

Target Location

Genome Build: GRCz11Chromosome: 2

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-wnt3a

No data available

Phenotype

Phenotype resulting from MO1-wnt3a

Phenotype	Fish	Figures
aortic arch morphology, abnormal	WT + MO1-wnt3a	Fig. 5 from Sun et al., 2008
ceratobranchial cartilage agenesis, abnormal	TU + MO1-wnt3a	Fig. 4, Table 1 from Neiswender et al., 2017
embryonic heart tube left/right pattern formation disrupted, abnormal	TL + MO1-wnt3a	Fig. 1 , Fig. 3 from Lin et al., 2009
embryonic viscerocranium morphogenesis disrupted, abnormal	WT + MO1-wnt3a	Fig. 4 from Neiswender et al., 2017 Fig. 5 from Sun et al., 2008
ethmoid cartilage aplastic, abnormal	TU + MO1-wnt3a	Fig. 4, Table 1 from Neiswender et al., 2017

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Phenotype of all Fish created by or utilizing MO1-wnt3a

Phenotype	Fish	Conditions	Figures
whole organism decreased length, abnormal	AB + MO1-wnt3a	standard conditions	Fig. 1 from Thorpe et al., 2005
somite decreased amount, abnormal	AB + MO1-wnt3a	standard conditions	Fig. 4 from Thorpe et al., 2005
tail bud decreased length, abnormal	AB + MO1-wnt3a	standard conditions	Fig. 1 from Thorpe et al., 2005
tail bud morphology, abnormal	AB + MO1-wnt3a	standard conditions	Fig. 4 from Thorpe et al., 2005
notochord truncated, abnormal	AB + MO1-wnt3a	standard conditions	Fig. 4 , Fig. 6 from Thorpe et al., 2005

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Citations

Include unpublished citations

Neiswender, H., Navarre, S., Kozlowski, D.J., LeMosy, E.K. (2017) Early Craniofacial Defects in Zebrafish That Have Reduced Function of a Wnt-Interacting Extracellular Matrix Protein, Tinagl1. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 54(4):381-390
Lin, X., and Xu, X. (2009) Distinct functions of Wnt/{beta}-catenin signaling in KV development and cardiac asymmetry. Development (Cambridge, England). 136(2):207-217
Sun, X., Zhang, R., Lin, X., and Xu, X. (2008) Wnt3a Regulates the Development of Cardiac Neural Crest Cells by Modulating Expression of Cysteine-Rich Intestinal Protein 2 in Rhombomere 6. Circulation research. 102(7):831-839
Shimizu, T., Bae, Y.K., and Hibi, M. (2006) Cdx-Hox code controls competence for responding to Fgfs and retinoic acid in zebrafish neural tissue. Development (Cambridge, England). 133(23):4709-4719
Shimizu, T., Bae, Y.K., Muraoka, O., and Hibi, M. (2005) Interaction of Wnt and caudal-related genes in zebrafish posterior body formation. Developmental Biology. 279(1):125-141
Thorpe, C.J., Weidinger, G., and Moon, R.T. (2005) Wnt/β-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development (Cambridge, England). 132(8):1763-1772

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