ZFIN Morpholino: MO1-foxa2

Target Location

Genome Build: GRCz11Chromosome: 17

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-foxa2

No data available

Phenotype

Phenotype resulting from MO1-foxa2

Phenotype	Fish	Figures
exocrine pancreas decreased size, abnormal	gz2Tg; gz4Tg; m1018Tg + MO1-foxa2	Fig. 7 from Shin et al., 2008
floor plate undifferentiated, abnormal	WT + MO1-foxa2	Fig. 1 from Dal-Pra et al., 2011
liver decreased size, abnormal	gz2Tg; gz4Tg; m1018Tg + MO1-foxa2	Fig. 7 from Shin et al., 2008
liver development disrupted, abnormal	gz2Tg; gz4Tg; m1018Tg + MO1-foxa2	Fig. 7 from Shin et al., 2008
pancreas decreased size, abnormal	WT + MO1-foxa2	Fig. 7 from Shin et al., 2008

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Phenotype of all Fish created by or utilizing MO1-foxa2

Phenotype	Fish	Conditions	Figures
floor plate undifferentiated, abnormal	WT + MO1-foxa2	standard conditions	Fig. 1 from Dal-Pra et al., 2011
post-vent region curved ventral, abnormal	WT + MO1-foxa2	standard conditions	Fig. 1 from Dal-Pra et al., 2011
pancreas development disrupted, abnormal	WT + MO1-foxa2	standard conditions	Fig. 7 from Shin et al., 2008
pancreas decreased size, abnormal	WT + MO1-foxa2	standard conditions	Fig. 7 from Shin et al., 2008
exocrine pancreas decreased size, abnormal	gz2Tg; gz4Tg; m1018Tg + MO1-foxa2	standard conditions	Fig. 7 from Shin et al., 2008

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Citations

Include unpublished citations

Amorim, J.P., Gali-Macedo, A., Marcelino, H., Bordeira-Carriço, R., Naranjo, S., Rivero-Gil, S., Teixeira, J., Galhardo, M., Marques, J., Bessa, J. (2020) A Conserved Notochord Enhancer Controls Pancreas Development in Vertebrates. Cell Reports. 32:107862
Lai, Y.R., Lu, Y.F., Lien, H.W., Huang, C.J., Hwang, S.L. (2016) Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos. The Biochemical journal. 473(14):2205-18
Dal-Pra, S., Thisse, C., and Thisse, B. (2011) FoxA transcription factors are essential for the development of dorsal axial structures. Developmental Biology. 350(2):484-495
Muto, A., Calof, A.L., Lander, A.D., and Schilling, T.F. (2011) Multifactorial Origins of Heart and Gut Defects in nipbl-Deficient Zebrafish, a Model of Cornelia de Lange Syndrome. PLoS Biology. 9(10):e1001181
Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y. (2008) Multiple roles for Med12 in vertebrate endoderm development. Developmental Biology. 317(2):467-479
Seiliez, I., Thisse, B., and Thisse, C. (2006) FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation. Developmental Biology. 290(1):152-163
Norton, W.H., Mangoli, M., Lele, Z., Pogoda, H.M., Diamond, B., Mercurio, S., Russell, C., Teraoka, H., Stickney, H.L., Rauch, G.J., Heisenberg, C.P., Houart, C., Schilling, T.F., Frohnhoefer, H.G., Rastegar, S., Neumann, C.J., Gardiner, R.M., Strähle, U., Geisler, R., Rees, M., Talbot, W.S., and Wilson, S.W. (2005) Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development (Cambridge, England). 132(4):645-658
Rastegar, S., Albert, S., Le Roux, I., Fischer, N., Blader, P., Müller, F., and Strähle, U. (2002) A floor plate enhancer of the zebrafish netrin1 gene requires Cyclops (Nodal) signalling and the winged helix transcription factor FoxA2. Developmental Biology. 252(1):1-14

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