ZFIN Morpholino: MO1-prox1a

Target Location

Genome Assembly: GRCz11Chromosome: 17

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-prox1a

No data available

Phenotype

Phenotype resulting from MO1-prox1a

Phenotype	Fish	Figures
hypothalamus neuron decreased amount, abnormal	AB + MO1-prox1a	Fig. 2 , Fig. 3 , Fig. S3 from Pistocchi et al., 2008
lymphangiogenesis disrupted, abnormal	y1Tg + MO1-prox1a	Fig. 2 from Yaniv et al., 2007
lymphatic endothelial cell differentiation disrupted, abnormal	WT + MO1-prox1a	Fig. 6 from Flores et al., 2010
neuromast somatic stem cell immature, abnormal	s356tTg + MO1-prox1a	Fig. 5 from Pistocchi et al., 2009
neuromast hair cell decreased amount, abnormal	WT + MO1-prox1a	Fig. 5 , Fig. S1 from Pistocchi et al., 2009

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Phenotype of all Fish created by or utilizing MO1-prox1a

Phenotype	Fish	Conditions	Figures
hypothalamus neuron decreased amount, abnormal	AB + MO1-prox1a	standard conditions	Fig. 2 , Fig. 3 , Fig. S3 from Pistocchi et al., 2008
lymphatic endothelial cell differentiation disrupted, abnormal	WT + MO1-prox1a	standard conditions	Fig. 6 from Flores et al., 2010
neuromast hair cell kinocilium absent, abnormal	WT + MO1-prox1a	standard conditions	Fig. 4 from Pistocchi et al., 2009
neuromast hair cell decreased amount, abnormal	WT + MO1-prox1a	standard conditions	Fig. S1 from Pistocchi et al., 2009
posterior lateral line neuromast decreased amount, abnormal	WT + MO1-prox1a	standard conditions	Fig. 3 , Fig. S1 from Pistocchi et al., 2009

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Citations

Include unpublished citations

Veen, K., Krylov, A., Yu, S., He, J., Boyd, P., Hyde, D.R., Mantamadiotis, T., Cheng, L.Y., Jusuf, P.R. (2023) Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genetics. 19:e1011010e1011010
Wakayama, Y., Fukuhara, S., Ando, K., Matsuda, M., Mochizuki, N. (2015) Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish. Developmental Cell. 32:109-22
Del Giacco, L., Pistocchi, A., and Ghilardi, A. (2010) prox1b Activity Is Essential in Zebrafish Lymphangiogenesis. PLoS One. 5(10):e13170
Flores, M.V., Hall, C.J., Crosier, K.E., and Crosier, P.S. (2010) Visualization of embryonic lymphangiogenesis advances the use of the zebrafish model for research in cancer and lymphatic pathologies. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2128-2135
Pistocchi, A., Feijoo, C.G., Cabrera, P., Villablanca, E.J., Allende, M.L., and Cotelli, F. (2009) The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line. BMC Developmental Biology. 9:58
Pistocchi, A., Bartesaghi, S., Cotelli, F., and Del Giacco, L. (2008) Identification and expression pattern of zebrafish prox2 during embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3916-3920
Pistocchi, A., Gaudenzi, G., Carra, S., Bresciani, E., Del Giacco, L., and Cotelli, F. (2008) Crucial role of zebrafish prox1 in hypothalamic catecholaminergic neurons development. BMC Developmental Biology. 8:27
Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2007) Imaging the developing lymphatic system using the zebrafish. Novartis Foundation symposium. 283(1):139-148
Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2006) Live imaging of lymphatic development in the zebrafish. Nature medicine. 12(6):711-716
Liu, Y.W., Gao, W., Teh, H.L., Tan, J.H., and Chan, W.K. (2003) Prox1 is a novel coregulator of Ff1b and is involved in the embryonic development of the zebra fish interrenal primordium. Molecular and cellular biology. 23(20):7243-7255

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