ZFIN Morpholino: MO1-gli1

Target Location

Genome Assembly: GRCz11Chromosome: 6

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-gli1

No data available

Phenotype

Phenotype resulting from MO1-gli1

Phenotype	Fish	Figures
adenohypophysis physical object quality, abnormal	WT + MO1-gli1	Fig. 5 from Devine et al., 2009
adenohypophysis morphogenesis process quality, abnormal	WT + MO1-gli1	Fig. 5 from Devine et al., 2009
somatotropin secreting cell decreased amount, abnormal	WT + MO1-gli1	Fig. 4 from Devine et al., 2009
somatotropin secreting cell differentiation process quality, abnormal	WT + MO1-gli1	Fig. 4 from Devine et al., 2009

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Phenotype of all Fish created by or utilizing MO1-gli1

Phenotype	Fish	Conditions	Figures
somatotropin secreting cell decreased amount, abnormal	WT + MO1-gli1	standard conditions	Fig. 4 from Devine et al., 2009
adenohypophysis morphogenesis process quality, abnormal	WT + MO1-gli1	standard conditions	Fig. 5 from Devine et al., 2009
adenohypophysis physical object quality, abnormal	WT + MO1-gli1	standard conditions	Fig. 5 from Devine et al., 2009
somatotropin secreting cell differentiation process quality, abnormal	WT + MO1-gli1	standard conditions	Fig. 4 from Devine et al., 2009
cell proliferation in hindbrain occurrence, ameliorated	cdh2^r210/r210 + MO1-gli1 + MO1-gli2a	standard conditions	Fig. 5 from Chalasani et al., 2011

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Citations

Include unpublished citations

Maurya, A.K., Ben, J., Zhao, Z., Lee, R.T., Niah, W., Ng, A.S., Iyu, A., Yu, W., Elworthy, S., van Eeden, F.J., and Ingham, P.W. (2013) Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genetics. 9(12):e1003955
Stückemann, T., Wegleiter, T., Stefan, E., Nägele, O., Tarbashevich, K., Böck, G., Raz, E., and Aanstad, P. (2012) Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling. Development (Cambridge, England). 139(15):2711-2720
Chalasani, K., and Brewster, R.M. (2011) N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube. Molecular biology of the cell. 22(9):1505-1515
England, S., Batista, M.F., Mich, J.K., Chen, J.K., and Lewis, K.E. (2011) Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons. Development (Cambridge, England). 138(23):5121-5134
Mich, J.K., and Chen, J.K. (2011) Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish. Development (Cambridge, England). 138(23):5113-5119
Devine, C.A., Sbrogna, J.L., Guner, B., Osgood, M., Shen, M.C., and Karlstrom, R.O. (2009) A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary. Developmental Biology. 326(1):143-154
Huang, P., and Schier, A.F. (2009) Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development (Cambridge, England). 136(18):3089-3098
Ninkovic, J., Stigloher, C., Lillesaar, C., and Bally-Cuif, L. (2008) Gsk3{beta}/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity. Development (Cambridge, England). 135(18):3137-3148
Masai, I., Yamaguchi, M., Tonou-Fujimori, N., Komori, A., and Okamoto, H. (2005) The hedgehog-PKA pathway regulates two distinct steps of the differentiation of retinal ganglion cells: the cell-cycle exit of retinoblasts and their neuronal maturation. Development (Cambridge, England). 132(7):1539-1553
Tyurina, O.V., Guner, B., Popova, E., Feng, J., Schier, A.F., Kohtz, J.D., and Karlstrom, R.O. (2005) Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Developmental Biology. 277(2):537-556

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