ZFIN Morpholino: MO1-twsg1b

Target Location

Genome Build: GRCz11Chromosome: KN150650.1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-twsg1b

No data available

Phenotype

Phenotype resulting from MO1-twsg1b

Phenotype	Fish	Figures
caudal artery ephb4a expression increased distribution, abnormal	y1Tg + MO1-twsg1b	Fig. 2 from Esser et al., 2018
caudal vein plexus dilated, abnormal	y1Tg + MO1-twsg1b	Fig. 1, Fig. 2 from Esser et al., 2018
caudal vein plexus ephb4a expression increased amount, abnormal	y1Tg + MO1-twsg1b	Fig. 2 from Esser et al., 2018
caudal vein plexus efnb2a expression increased amount, abnormal	y1Tg + MO1-twsg1b	Fig. 1 from Esser et al., 2018
caudal vein plexus efnb2a expression increased distribution, abnormal	y1Tg + MO1-twsg1b	Fig. 1 from Esser et al., 2018

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Phenotype of all Fish created by or utilizing MO1-twsg1b

Phenotype	Fish	Conditions	Figures
caudal vein plexus efnb2a expression increased amount, abnormal	y1Tg + MO1-twsg1b	standard conditions	Fig. 1 from Esser et al., 2018
intersegmental vein malformed, abnormal	y1Tg + MO1-twsg1b	standard conditions	Fig. 8 from Heinke et al., 2013
caudal vein plexus dilated, abnormal	y1Tg + MO1-twsg1b	standard conditions	Fig. 1, Fig. 2 from Esser et al., 2018
caudal vein plexus ephb4a expression increased distribution, abnormal	y1Tg + MO1-twsg1b	standard conditions	Fig. 2 from Esser et al., 2018
dorsal longitudinal anastomotic vessel malformed, abnormal	y1Tg + MO1-twsg1b	standard conditions	Fig. 8 from Heinke et al., 2013

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Citations

Include unpublished citations

Esser, J.S., Steiner, R.E., Deckler, M., Schmitt, H., Engert, B., Link, S., Charlet, A., Patterson, C., Bode, C., Zhou, Q., Moser, M. (2018) Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells. The FEBS journal. 285(8):1419-1436
Heinke, J., Juschkat, M., Charlet, A., Mnich, L., Helbing, T., Bode, C., Patterson, C., and Moser, M. (2013) Antagonism and synergy between extracellular BMP modulators Tsg and BMPER to balance blood vessel formation. Journal of Cell Science. 126(Pt 14):3082-94
Xie, J., and Fisher, S. (2005) Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms. Development (Cambridge, England). 132(2):383-391
Little, S.C., and Mullins, M.C. (2004) Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development (Cambridge, England). 131(23):5825-5835
Ross, J.J., Shimmi, O., Vilmos, P., Petryk, A., Kim, H., Gaudenz, K., Hermanson, S., Ekker, S.C., O'Connor, M.B., and Marsh, J.L. (2001) Twisted gastrulation is a conserved extracellular BMP antagonist. Nature. 410(6827):479-483

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