ZFIN ID: ZDB-LAB-990426-1
Slusarski Lab
PI/Director: Slusarski, Diane C.
Contact Person: Slusarski, Diane C.
Email: diane-slusarski@uiowa.edu
URL: http://biology-afs.biology.uiowa.edu/Faculty/Slusarski
Address: The University of Iowa Department of Biological Sciences 136 Biology Building Iowa City, IA 52242 USA
Country: United States
Phone: (319) 335-3229
Fax: (319) 335-1069
Line Designation: ui


GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Brastrom, L.K., Scott, C.A., Wang, K., Slusarski, D.C. (2021) Functional Role of the RNA-Binding Protein Rbm24a and Its Target sox2 in Microphthalmia. Biomedicines. 9(2):
Dash, S., Brastrom, L.K., Patel, S.D., Scott, C.A., Slusarski, D.C., Lachke, S.A. (2019) The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development. Human molecular genetics. 29(4):591-604
Brastrom, L.K., Scott, C.A., Dawson, D.V., Slusarski, D.C. (2019) A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Biomedicines. 7(2)
Fuller, T.D., Westfall, T.A., Das, T., Dawson, D.V., Slusarski, D.C. (2018) High-throughput behavioral assay to investigate seizure sensitivity in zebrafish implicates ZFHX3 in epilepsy. Journal of neurogenetics. 32(2):92-105
Eno, C., Gomez, T., Slusarski, D.C., Pelegri, F. (2018) Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo. Development (Cambridge, England). 145(10)
Marsden, A.N., Derry, S.W., Schneider, I., Scott, C.A., Westfall, T.A., Brastrom, L.K., Shea, M., Dawson, D.V., Slusarski, D.C. (2017) The Nkd EF-Hand Domain Modulates Divergent Wnt Signaling Outputs in Zebrafish. Developmental Biology. 434(1):63-73
Scott, C.A., Marsden, A.N., Rebagliati, M.R., Zhang, Q., Chamling, X., Searby, C.C., Baye, L.M., Sheffield, V.C., Slusarski, D.C. (2017) Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein. PLoS Genetics. 13:e1006936
Heon, E., Kim, G., Qin, S., Garrison, J.E., Tavares, E., Vincent, A., Nuangchamnong, N., Scott, C.A., Slusarski, D.C., Sheffield, V.C. (2016) Mutations in C8ORF37 cause Bardet Biedl syndrome (BBS21). Human molecular genetics. 25(11):2283-2294
Scott, C.A., Marsden, A.N., Slusarski, D.C. (2016) Automated, high-throughput, in vivo analysis of visual function using the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 245(5):605-13
DeLuca, A.P., Whitmore, S.S., Barnes, J., Sharma, T.P., Westfall, T.A., Scott, C.A., Weed, M.C., Wiley, J.S., Wiley, L.A., Johnston, R.M., Schnieders, M.J., Lentz, S.R., Tucker, B.A., Mullins, R.F., Scheetz, T.E., Stone, E.M., Slusarski, D.C. (2016) Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. Human molecular genetics. 25(1):44-56
Mei, X., Westfall, T.A., Zhang, Q., Sheffield, V.C., Bassuk, A.G., Slusarski, D.C. (2014) Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms. Developmental Biology. 392(2):245-55
Chamling, X., Seo, S., Searby, C.C., Kim, G., Slusarski, D.C., Sheffield, V.C. (2014) The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.. PLoS Genetics. 10(2):e1004083
Mei, X., Wu, S., Bassuk, A.G., and Slusarski, D.C. (2013) Mechanisms of prickle 1a function in zebrafish epilepsy and retinal neurogenesis. Disease models & mechanisms. 6(3):679-688
Schneider, P.N., Slusarski, D.C., and Houston, D.W. (2012) Differential Role of Axin RGS Domain Function in Wnt Signaling during Anteroposterior Patterning and Maternal Axis Formation. PLoS One. 7(9):e44096
Wright, K.J., Baye, L.M., Olivier-Mason, A., Mukhopadhyay, S., Sang, L., Kwong, M., Wang, W., Pretorius, P.R., Sheffield, V.C., Sengupta, P., Slusarski, D.C., and Jackson, P.K. (2011) An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes & Development. 25(22):2347-2360
Baye, L.M., Patrinostro, X., Swaminathan, S., Beck, J.S., Zhang, Y., Stone, E.M., Sheffield, V.C., and Slusarski, D.C. (2011) The N-terminal region of centrosomal protein 290 (CEP290) restores vision in a zebrafish model of human blindness. Human molecular genetics. 20(8):1467-77
Pretorius, P.R., Aldahmesh, M.A., Alkuraya, F.S., Sheffield, V.C., and Slusarski, D.C. (2011) Functional analysis of BBS3 A89V that results in non-syndromic retinal degeneration. Human molecular genetics. 20(8):1625-1632
Westlake, C.J., Baye, L.M., Nachury, M.V., Wright, K.J., Ervin, K.E., Phu, L., Chalouni, C., Beck, J.S., Kirkpatrick, D.S., Slusarski, D.C., Sheffield, V.C., Scheller, R.H., and Jackson, P.K. (2011) Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proceedings of the National Academy of Sciences of the United States of America. 108(7):2759-2764
Tao, H., Manak, J.R., Sowers, L., Mei, X., Kiyonari, H., Abe, T., Dahdaleh, N.S., Yang, T., Wu, S., Chen, S., Fox, M.H., Gurnett, C., Montine, T., Bird, T., Shaffer, L.G., Rosenfeld, J.A., McConnell, J., Madan-Khetarpal, S., Berry-Kravis, E., Griesbach, H., Saneto, R.P., Scott, M.P., Antic, D., Reed, J., Boland, R., Ehaideb, S.N., El-Shanti, H., Mahajan, V.B., Ferguson, P.J., Axelrod, J.D., Lehesjoki, A.E., Fritzsch, B., Slusarski, D.C., Wemmie, J., Ueno, N., and Bassuk, A.G. (2011) Mutations in Prickle Orthologs Cause Seizures in Flies, Mice, and Humans. American journal of human genetics. 88(2):138-149
Schneider, I., Schneider, P.N., Derry, S.W., Lin, S., Barton, L.J., Westfall, T., and Slusarski, D.C. (2010) Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Developmental Biology. 348(1):22-33
Lin, S., Baye, L.M., Westfall, T.A., and Slusarski, D.C. (2010) Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement. The Journal of cell biology. 190(2):263-278
Freisinger, C.M., Fisher, R.A., and Slusarski, D.C. (2010) Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning. PLoS Genetics. 6(7):e1001020
Nishimura, D.Y., Baye, L.M., Perveen, R., Searby, C.C., Avila-Fernandez, A., Pereiro, I., Ayuso, C., Valverde, D., Bishop, P.N., Manson, F.D., Urquhart, J., Stone, E.M., Slusarski, D.C., Black, G.C., and Sheffield, V.C. (2010) Discovery and Functional Analysis of a Retinitis Pigmentosa Gene, C2ORF71. American journal of human genetics. 86(5):686-695
Pretorius, P.R., Baye, L.M., Nishimura, D.Y., Searby, C.C., Bugge, K., Yang, B., Mullins, R.F., Stone, E.M., Sheffield, V.C., and Slusarski, D.C. (2010) Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform. PLoS Genetics. 6(3):e1000884
Seo, S., Baye, L.M., Schulz, N.P., Beck, J.S., Zhang, Q., Slusarski, D.C., and Sheffield, V.C. (2010) BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. Proceedings of the National Academy of Sciences of the United States of America. 107(4):1488-1493
Holloway, B.A., Gomez de la Torre Canny, S., Ye, Y., Slusarski, D.C., Freisinger, C.M., Dosch, R., Chou, M.M., Wagner, D.S., and Mullins, M.C. (2009) A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genetics. 5(3):e1000413
Loktev, A.V., Zhang, Q., Beck, J.S., Searby, C.C., Scheetz, T.E., Bazan, J.F., Slusarski, D.C., Sheffield, V.C., Jackson, P.K., and Nachury, M.V. (2008) A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation. Developmental Cell. 15(6):854-865
Bassuk, A.G., Wallace, R.H., Buhr, A., Buller, A.R., Afawi, Z., Shimojo, M., Miyata, S., Chen, S., Gonzalez-Alegre, P., Griesbach, H.L., Wu, S., Nashelsky, M., Vladar, E.K., Antic, D., Ferguson, P.J., Cirak, S., Voit, T., Scott, M.P., Axelrod, J.D., Gurnett, C., Daoud, A.S., Kivity, S., Neufeld, M.Y., Mazarib, A., Straussberg, R., Walid, S., Korczyn, A.D., Slusarski, D.C., Berkovic, S.F., and El-Shanti, H.I. (2008) A Homozygous Mutation in Human PRICKLE1 Causes an Autosomal-Recessive Progressive Myoclonus Epilepsy-Ataxia Syndrome. American journal of human genetics. 83(5):572-581
Tayeh, M.K., Yen, H.J., Beck, J.S., Searby, C.C., Westfall, T.A., Griesbach, H., Sheffield, V.C., and Slusarski, D.C. (2008) Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning. Human molecular genetics. 17(13):1956-1967
Freisinger, C.M., Schneider, I., Westfall, T.A., and Slusarski, D.C. (2008) Calcium dynamics integrated into signalling pathways that influence vertebrate axial patterning. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 363(1495):1377-1385
Cirone, P., Lin, S., Griesbach, H.L., Zhang, Y., Slusarski, D.C., and Crews, C.M. (2008) A role for planar cell polarity signaling in angiogenesis. Angiogenesis. 11(4):347-360
Freisinger, C.M., Houston, D.W., and Slusarski, D.C. (2008) Image analysis of calcium release dynamics. Methods in molecular biology (Clifton, N.J.). 468:145-156
Schneider, I., Houston, D.W., Rebagliati, M.R., and Slusarski, D.C. (2008) Calcium fluxes in dorsal forerunner cells antagonize {beta}-catenin and alter left-right patterning. Development (Cambridge, England). 135(1):75-84
Slusarski, D.C., and Pelegri, F. (2007) Calcium signaling in vertebrate embryonic patterning and morphogenesis. Developmental Biology. 307(1):1-13
Zhang, Y., Yeh, J.R., Mara, A., Ju, R., Hines, J.F., Cirone, P., Griesbach, H.L., Schneider, I., Slusarski, D.C., Holley, S.A., and Crews, C.M. (2006) A chemical and genetic approach to the mode of action of fumagillin. Chemistry & Biology. 13(9):1001-1009
Chiang, A.P., Beck, J.S., Yen, H.J., Tayeh, M.K., Scheetz, T.E., Swiderski, R.E., Nishimura, D.Y., Braun, T.A., Kim, K.Y., Huang, J.,. Elbedour, K., Carmi, R., Slusarski, D.C., Casavant, T.L., Stone, E.M., and Sheffield, V.C. (2006) Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proceedings of the National Academy of Sciences of the United States of America. 103(16):6287-6292
Yen, H.J., Tayeh, M.K., Mullins, R.F., Stone, E.M., Sheffield, V.C., and Slusarski, D.C. (2006) Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function. Human molecular genetics. 15(5):667-677
Lyman Gingerich, J., Westfall, T.A., Slusarski, D.C., and Pelegri, F. (2005) hecate, a zebrafish maternal effect gene, affects dorsal organizer induction and intracellular calcium transient frequency. Developmental Biology. 286(2):427-439
Westfall, T.A., Brimeyer, R., Twedt, J., Gladon, J., Olberding, A., Furutani-Seiki, M., and Slusarski, D.C. (2003) Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/{beta}-catenin activity. The Journal of cell biology. 162(5):889-898
Westfall, T.A., Hjertos, B., and Slusarski, D.C. (2003) Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Developmental Biology. 259(2):380-391
Sheldahl, L.C., Slusarski, D.C., Pandur, P., Miller, J.R., Kühl, M., and Moon, R.T. (2003) Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. The Journal of cell biology. 161(4):769-777
Veeman, M.T., Slusarski, D.C., Kaykas, A., Louie, S.H., and Moon, R.T. (2003) Zebrafish prickle, a modulator of noncanonical wnt/fz signaling, regulates gastrulation movements. Current biology : CB. 13(8):680-685
Ahumada, A., Slusarski, D.C., Liu, X., Moon, R.T., Malbon, C.C. and Wang, H.-Y. (2002) Signaling of rat frizzled-2 through phosphodiesterase and cyclic guanosine 3', 5'-monophosphate. Science (New York, N.Y.). 298:2006-2010
Slusarski, D.C., Hjertos, B., and Humbert, J. (2002) Mechanisms of calcium signaling in zebrafish development. Developmental Biology. 247(2):455
Slusarski, D.C., Hjertos, B.E., Humbert, J.E., and Westfall, T. (2001) Mechanisms of non-canonical Wnt (Wnt-5A and Wnt-11) signaling in zebrafish. Molecular biology of the cell. (Suppl.) 12:1305
Slusarski, D.C., and Corces, V.G. (2000) Calcium imaging in cell-cell signaling. Methods in molecular biology (Clifton, N.J.). 135:349-355
Liu, X., Liu, T., Slusarski, D., Yang-Snyder, J., Malbon, C., Moon, R., and Wang, H.-Y. (1999) Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. Proceedings of the National Academy of Sciences of the United States of America. 96(25):14383-14388
Slusarski, D. and Corces, V. (1999) Calcium imaging and cell-cell signaling. In Methods in Molecular Biology, R.S. Tuan and C.W. Lo, eds., Developmental Biology Protocols, Humana Press, Inc., Totowa.
Slusarski, D., V. Corces, and R. Moon (1997) Interaction of a Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signaling. Nature. 390:410-413
Slusarski, D.C., Yang-Snyder, J., Busa, W.B., and Moon, R.T. (1997) Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Developmental Biology. 182(1):114-120