ZFIN ID: ZDB-LAB-971020-5
Stürmer Lab
PI/Director: Stuermer, Claudia
Contact Person: Loos, Anett-Yvonn
Email: claudia.stuermer@uni-konstanz.de
URL: http://www.uni-konstanz.de/FuF/Bio/forsch/zoology/stuermerlab/index.html
Address: Fakultät für Biologie Universitat Konstanz Konstanz, D-78434 Germany
Country: Germany
Phone: 49-7531-883377
Fax: 49-7531-883894
Line Designation: kn

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Axon growth and regeneration in the vertebrate central nervous system (CNS) is governed by neuron intrinsic properties and molecular components in the neuron's environment.

We investigate the function of specific cell surface proteins in the CNS of fish whose expression accompanies axon growth in the embryo and successful axon regeneration (upon lesion) in the adult. Also we analyze expression of related proteins in the CNS of mammals under conditions which allow some lesioned neurons to regenerate their axons. In addition the properties of CNS glial cells are being explored with emphasis on their contribution to success of axon regeneration and fiber tract repair in fish and other "lower" vertebrates.

Laessing, Ute Post-Doc Diekmann, Heike Graduate Student Klinger, Michael Graduate Student
Loos, Anett-Yvonn

Bodrikov, V., Welte, C., Wiechers, M., Weschenfelder, M., Kaur, G., Shypitsyna, A., Pinzon-Olejua, A., Bastmeyer, M., Stuermer, C.A.O. (2017) Substrate properties of zebrafish Rtn4b/Nogo and axon regeneration in the zebrafish optic nerve. The Journal of comparative neurology. 525(14):2991-3009
Pinzon-Olejua, A., Welte, C., Chekuru, A., Bosak, V., Brand, M., Hans, S., Stuermer, C.A. (2017) Cre inducible site-specific recombination in zebrafish oligodendrocytes. Developmental dynamics : an official publication of the American Association of Anatomists. 246(1):41-49
Levin, E., Diekmann, H., Fischer, D. (2016) Highly efficient transduction of primary adult CNS and PNS neurons. Scientific Reports. 6:38928
Diekmann, H., Kalbhen, P., Fischer, D. (2015) Active mechanistic target of rapamycin plays an ancillary rather than essential role in zebrafish CNS axon regeneration. Frontiers in Cellular Neuroscience. 9:251
Diekmann, H., Kalbhen, P., Fischer, D. (2015) Characterization of optic nerve regeneration using transgenic zebrafish. Frontiers in Cellular Neuroscience. 9:118
Welte, C., Engel, S., Stuermer, C.A. (2015) Upregulation of the zebrafish Nogo-A homologue, Rtn4b, in retinal ganglion cells is functionally involved in axon regeneration. Neural Development. 10:6
Fleming, A., Diekmann, H., and Goldsmith, P. (2013) Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One. 8(10):e77548
Van den Bulck, K., Hill, A., Mesens, N., Diekman, H., De Schaepdrijver, L., and Lammens, L. (2011) Zebrafish developmental toxicity assay: A fishy solution to reproductive toxicity screening, or just a red herring?. Reproductive toxicology (Elmsford, N.Y.). 32(2):213-9
Futter, M., Diekmann, H., Schoenmakers, E., Sadiq, O., Chatterjee, K., and Rubinsztein, D.C. (2009) Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors. Journal of Medical Genetics. 46(7):438-446
Diekmann, H., and Stuermer, C.A. (2009) Zebrafish neurolin-a and -b, orthologs of ALCAM, are involved in retinal ganglion cell differentiation and retinal axon pathfinding. The Journal of comparative neurology. 513(1):38-50
Diekmann, H., Anichtchik, O., Fleming, A., Futter, M., Goldsmith, P., Roach, A., and Rubinsztein, D.C. (2009) Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(5):1343-1349
Anichtchik, O., Diekmann, H., Fleming, A., Roach, A., Goldsmith, P., and Rubinsztein, D.C. (2008) Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(33):8199-8207
Diekmann, H., Klinger, M., Oertle, T., Heinz, D., Pogoda, H.M., Schwab, M.E., and Stuermer, C.A. (2005) Analysis of the Reticulon Gene Family Demonstrates the Absence of the Neurite Growth Inhibitor Nogo-A in Fish. Mol. Biol. Evol.. 22(8):1635-1648
Haenisch, C., Diekmann, H., Klinger, M., Gennarini, G., Kuwada, J.Y., and Stuermer, C.A. (2005) The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration. Molecular and cellular neurosciences. 28(2):361-374
Stürmer, C.A., and Plattner, H. (2005) Lipids, Rafts and Traffic: Chapter 11 - The 'lipid raft' microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling. Biochemical Society symposium. 72:109-118
Klinger, M., Taylor, J.S., Oertle, T., Schwab, M.E., Stürmer, C.A., and Diekmann, H. (2004) Identification of Nogo-66 receptor (NgR) and homologous genes in fish. Mol. Biol. Evol.. 21(1):76-85
Reuter, A., Málaga-Trillo, E., Binkle, U., Rivera-Milla, E., Beltre, R., Zhou, Y., Bastmeyer, M., and Stuermer, C.A.O. (2004) Evolutionary Analysis and Expression of Teleost Thy-1. Zebrafish. 1(3):191-201
Oertle, T., Klinger, M., Stürmer, C.A., and Schwab, M.E. (2003) A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 17(10):1238-1247
Deininger, S.O., Rajendran, L., Lottspeich, F., Przybylski, M., Illges, H., Stürmer, C.A., and Reuter, A. (2003) Identification of teleost Thy-1 and association with the microdomain/lipid raft reggie proteins in regenerating CNS axons. Molecular and cellular neurosciences. 22(4):544-54
Shen, H., Illges, H., Reuter, A., and Stürmer, C. (2002) Cloning, expression, and alternative splicing of neogenin1 in zebrafish. Mechanisms of Development. 118(1-2):219-223
Málaga-Trillo, E., Laessing, U., Lang, D.M., Meyer, A., and Stürmer, C.A.O. (2002) Evolution of duplicated reggie genes in zebrafish and goldfish. Journal of molecular evolution. 54(2):235-245
Ott, H., Diekmann, H., Stürmer, C.A.O., and Bastmeyer, M. (2001) Function of neurolin (DM-GRASP/SC-1) in guidance of motor axons during zebrafish development. Developmental Biology. 235(1):86-97
Lang, D.M., Warren, J.T., Klisa, C., and Stürmer, C.A. (2001) Topographic restriction of TAG-1 expression in the developing retinotectal pathway and target dependent reexpression during axon regeneration. Molecular and cellular neurosciences. 17(2):398-414
Petrausch, B., Tabibiazar, R., Roser, T., Jing, Y., Goldman, D., Stürmer, C.A., Irwin, N., and Benowitz, L.I. (2000) A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(21):8031-8041
Ott, H., Bastmeyer, M., and Stürmer, C.A.O. (2000) Function of neurolin in guidance of secondary motor axons in embryonic zebrafish. The European journal of neuroscience. 12:266
Weidinger, G., Wolke, U., Köprunner, M., Klinger, M., and Raz, E. (1999) Identification of tissues and patterning events required for distinct steps in early migration of zebrafish primordial germ cells. Development (Cambridge, England). 126(23):5295-5307
Kaethner, R.J. and Stürmer, C.A.O. (1997) Dynamics of process formation during differentiation of tectal neurons in embryonic zebrafish. Journal of neurobiology. 32(6):627-639
Weiland, U.M., Ott, H., Bastmeyer, M., Schaden, H., Giordano, S. and Stürmer, C.A.O. (1997) Expression of an L1-related cell adhesion molecule on developing CNS fiber tracts in zebrafish and its functional contribution to axon fasciculation. Molecular and cellular neurosciences. 9(1):77-89
Laessing, U. and Stürmer, C.A.O. (1996) Spatiotemporal pattern of retinal ganglion cell differentiation revealed by the expression of neurolin in embryonic zebrafish. Journal of neurobiology. 29:65-74
Kaethner, R.J. and Stürmer, C.A.O. (1994) Growth behavior of retinotectal axons in live zebrafish embryos under TTX-induced neural impulse blockade. Journal of neurobiology. 25:781-796
Laessing, U., Giordano, S., Stecher, B., Lottspeich, F., and Stürmer, C.A. (1994) Molecular characterization of fish neurolin: a growth-associated cell surface protein and member of the immunoglobulin superfamily in the fish retinotectal system with similarities to chick protein. Differentiation; research in biological diversity. 56:21-29
Kaethner, R.J. and Stürmer, C.A. (1992) Dynamics of terminal arbor formation and target approach of retinotectal axons in living zebrafish embryos: a time-lapse study of single axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 12:3257-3271
Stürmer, C.A.O., Rorer, B., and Muenz, H. (1990) Development of the retinotectal projection in zebrafish embryos under TTX-induced neural-impulse blockade. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10:3615-3626
Stürmer, C.A.O. (1988) Retinotopic organization of the developing retinotectal projection in the zebrafish embryo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 8:4513-4530
Kuschel, C. and Stürmer, C.A.O. (1988) Axotomy of retinal axons causes ganglion cell death in young larvae of zebrafish. Soc. Neurosci. Abstr.. 14:657
Stürmer, C.A.O. (1988) Development of the retinotectal projection in zebrafish embryos under TTX-induced blockade of neuronal activity. Soc. Neurosci. Abstr.. 14:178
Stürmer, C.A.O. and Vielmetter, J. (1987) Embryonic development of the retinotectal projection in zebrafish. Soc. Neurosci. Abstr.. 13:1689