ZFIN ID: ZDB-LAB-970909-44
Peterson Lab
PI/Director: Peterson, Richard E.
Co-PI / Senior
Researcher:		 Heidman, Warren
Contact Person: Xiong, Kong M.
Email: kxiong4@wisc.edu
URL:
Address: School of Pharmacy University of Wisconsin 5208 Rennebohm Hall 777 Highland Avenue Madison, WI 53705-2222 USA
Country: United States
Phone: (608) 262-4525
Fax: (608) 265-3316
Line Designation: f


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
Our lab studies the developmental and reproductive toxicity of polyhalogenated aromatic hydrocarbons.


LAB MEMBERS
Chen, Jing Graduate Student Mehta, Vatsal Graduate Student Sieprawska, Dagmara Graduate Student
Xiong, Kong M. Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Kim, M.S., Stees, M., Karuturi, B.V., Vijayaraghavalu, S., Peterson, R.E., Madsen, G.L., Labhasetwar, V. (2017) Pro-NP™ protect against TiO2 nanoparticle-induced phototoxicity in zebrafish model: exploring potential application for skin care. Drug delivery and translational research. 7:372
Nijoukubo, D., Tanaka, Y., Okuno, Y., Yin, G., Kitazawa, T., Peterson, R.E., Kubota, A., Teraoka, H. (2016) Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish. Chemosphere. 156:111-117
Mahmoud, M., Kim, H.R., Xing, R., Hsiao, S., Mammmoto, A., Chen, J., Serbanovic-Canic, J., Feng, S., Bowden, N.P., Maguire, R., Ariaans, M., Francis, S., Weinberg, P.D., Van der Heiden, K., Jones, E.A., Chico, T.J., Ridger, V.C., Evans, P.C. (2016) TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circulation research. 119(3):450-62
Burns, F.R., Lanham, K.A., Xiong, K.M., Gooding, A.J., Peterson, R.E., Heideman, W. (2016) Analysis of the Zebrafish sox9b Promoter: Identification of Elements that Recapitulate Organ-Specific Expression of sox9b. Gene. 578(2):281-9
Yue, M.S., Plavicki, J.S., Li, X.Y., Peterson, R.E., Heideman, W. (2015) A co-culture assay of embryonic zebrafish hearts to assess migration of epicardial cells in vitro. BMC Developmental Biology. 15:50
Yue, M.S., Peterson, R.E., Heideman, W. (2015) Dioxin inhibition of swim bladder development in zebrafish: Is it secondary to heart failure?. Aquatic toxicology (Amsterdam, Netherlands). 162:10-17
Chen, J. (2015) Cardiac toxicity by sublethal 2,3,7,8-tetrachlorodibenzo-p-dioxin correlates with its anti-proliferation effect upon cardiomyocytes in zebrafish embryos. Environmental toxicology and chemistry. 34(2):420-8
Baker, T.R., King-Heiden, T.C., Peterson, R.E., Heideman, W. (2014) Dioxin induction of transgenerational inheritance of disease in zebrafish. Molecular and Cellular Endocrinology. 398(1-2):36-41
Chen, J., Ingham, N., Kelly, J., Jadeja, S., Goulding, D., Pass, J., Mahajan, V.B., Tsang, S.H., Nijnik, A., Jackson, I.J., White, J.K., Forge, A., Jagger, D., Steel, K.P. (2014) Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss. PLoS Genetics. 10:e1004688
Lanham, K.A., Plavicki, J., Peterson, R.E., Heideman, W. (2014) Cardiac Myocyte-Specific AHR Activation Phenocopies TCDD-Induced Toxicity in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 141(1):141-54
Teraoka, H., Okuno, Y., Nijoukubo, D., Yamakoshi, A., Peterson, R.E., Stegeman, J.J., Kitazawa, T., Hiraga, T., Kubota, A. (2014) Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 154C:19-26
Plavicki, J.S., Hofsteen, P., Yue, M.S., Lanham, K.A., Peterson, R.E., Heideman, W. (2014) Multiple modes of proepicardial cell migration require heartbeat. BMC Developmental Biology. 14:18
Baker, T.R., Peterson, R.E., and Heideman, W. (2014) Using zebrafish as a model system for studying the transgenerational effects of dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 138(2):403-411
Plavicki, J.S., Baker, T.R., Burns, F.R., Xiong, K.M., Gooding, A.J., Hofsteen, P., Peterson, R.E., Heideman, W. (2014) Construction and characterization of a sox9b transgenic reporter line.. The International journal of developmental biology. 58(9):693-9
Baker, T.R., Peterson, R.E., and Heideman, W. (2013) Early dioxin exposure causes toxic effects in adult zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 135(1):241-50
Chen, J. (2013) Impaired Cardiovascular Function Caused by Different Stressors Elicits a Common Pathological and Transcriptional Response in Zebrafish Embryos. Zebrafish. 10(3):389-400
Hofsteen, P., Plavicki, J., Johnson, S.D., Peterson, R.E., and Heideman, W. (2013) Sox9b is Required for Epicardium Formation and Plays a Role in TCDD-induced Heart Malformation in Zebrafish. Molecular pharmacology. 84(3):353-60
Wiecinski, P., Metz, K.M., King Heiden, T.C., Louis, K., Mangham, A., Hamers, R.J., Heideman, W., Peterson, R.E., and Pedersen, J.A. (2013) Toxicity of Oxidatively Degraded Quantum Dots. Environmental science & technology. 47(16):9132-9
Hofsteen, P., Plavicki, J., Peterson, R.E., Heideman, W. (2013) Epicardium Formation as a Sensor in Toxicology. Journal of developmental biology. 1:112-125
Zhang, J., Lanham, K.A., Heideman, W., Peterson, R.E., and Li, L. (2013) Statistically Enhanced Spectral Counting Approach to TCDD Cardiac Toxicity in the Adult Zebrafish Heart. Journal of Proteome Research. 12(7):3093-103
Bar-Ilan, O., Chuang, C.C., Schwahn, D.J., Yang, S., Joshi, S., Pedersen, J.A., Hamers, R.J., Peterson, R.E., and Heideman, W. (2013) TiO2 nanoparticle exposure and illumination during zebrafish development: Mortality at parts per billion concentrations. Environmental science & technology. 47(9):4726-33
Yang, S., Bar-Ilan, O., Peterson, R.E., Heideman, W., Hamers, R.J., and Pedersen, J.A. (2013) Influence of Humic Acid on Titanium Dioxide Nanoparticle Toxicity to Developing Zebrafish. Environmental science & technology. 47(9):4718-4725
Hofsteen, P., Mehta, V., Kim, M.S., Peterson, R.E., and Heideman, W. (2013) TCDD Inhibits Heart Regeneration in Adult Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 132(1):211-221
Plavicki, J., Hofsteen, P., Peterson, R.E., and Heideman, W. (2013) Dioxin inhibits zebrafish epicardium and proepicardium development. Toxicological sciences : an official journal of the Society of Toxicology. 131(2):558-567
Zhang, J., Lanham, K.A., Heideman, W., Peterson, R.E., and Li, L. (2013) Characterization of Zebrafish Cardiac Proteome Using Online pH Gradient SCX-RP HPLC-MS/MS Platform. Methods in molecular biology (Clifton, N.J.). 1005:119-127
Bar-Ilan, O., Louis, K.M., Yang, S.P., Pedersen, J.A., Hamers, R.J., Peterson, R.E., and Heideman, W. (2012) Titanium dioxide nanoparticles produce phototoxicity in the developing zebrafish. Nanotoxicology. 6:670-679
Lanham, K.A., Peterson, R.E., and Heideman, W. (2012) Sensitivity to Dioxin Decreases as Zebrafish Mature. Toxicological sciences : an official journal of the Society of Toxicology. 127(2):360-370
King-Heiden, T.C., Mehta, V., Xiong, K.M., Lanham, K.A., Antkiewicz, D.S., Ganser, A., Heideman, W., and Peterson, R.E. (2012) Reproductive and developmental toxicity of dioxin in fish. Molecular and Cellular Endocrinology. 354(1-2):121-138
Taylor, S., Chen, J., Luo, J., and Hitchcock, P. (2012) Light-induced photoreceptor degeneration in the retina of the zebrafish. Methods in molecular biology (Clifton, N.J.). 884:247-254
Yoshioka, W., Peterson, R.E., and Tohyama, C. (2011) Molecular targets that link dioxin exposure to toxicity phenotypes. The Journal of steroid biochemistry and molecular biology. 127(1-2):96-101
Kubota, A., Stegeman, J.J., Woodin, B.R., Iwanaga, T., Harano, R., Peterson, R.E., Hiraga, T., and Teraoka, H. (2011) Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2. Toxicology and applied pharmacology. 253(3):244-52
Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8
Lanham, K.A., Prasch, A.L., Weina, K.M., Peterson, R.E., and Heideman, W. (2011) A dominant negative zebrafish ahr2 partially protects developing zebrafish from dioxin toxicity. PLoS One. 6(12):e28020
Teraoka, H., Ogawa, A., Kubota, A., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2010) Malformation of certain brain blood vessels caused by TCDD activation of Ahr2/Arnt1 signaling in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 99(2):241-247
Zhang, J., Lanham, K.A., Peterson, R.E., Heideman, W., and Li, L. (2010) Characterization of the adult zebrafish cardiac proteome using online pH gradient strong cation exchange-RP 2D LC coupled with ESI MS/MS. Journal of separation science. 33(10):1462-1471
King Heiden, T.C., Spitsbergen, J., Heideman, W., and Peterson, R.E. (2009) Persistent Adverse Effects on Health and Reproduction Caused by Exposure of Zebrafish to 2,3,7,8-Tetrachlorodibenzo-p-dioxin During Early Development and Gonad Differentiation. Toxicological sciences : an official journal of the Society of Toxicology. 109(1):75-87
Hill, A.J., Heiden, T.C., Heideman, W., and Peterson, R.E. (2009) Potential roles of arnt2 in zebrafish larval development. Zebrafish. 6(1):79-91
King-Heiden, T.C., Wiecinski, P.N., Mangham, A.N., Metz, K.M., Nesbit, D., Pedersen, J.A., Hamers, R.J., Heideman, W., and Peterson, R.E. (2009) Quantum dot nanotoxicity assessment using the zebrafish embryo. Environmental science & technology. 43(5):1605-1611
Teraoka, H., Kubota, A., Dong, W., Kawai, Y., Yamazaki, K., Mori, C., Harada, Y., Peterson, R.E., and Hiraga, T. (2009) Role of the cyclooxygenase 2-thromboxane pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced decrease in mesencephalic vein blood flow in the zebrafish embryo. Toxicology and applied pharmacology. 234(1):33-40
Xiong, K.M., Peterson, R.E., and Heideman, W. (2008) Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Molecular pharmacology. 74(6):1544-1553
Mehta, V., Peterson, R.E., and Heideman, W. (2008) 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Prevents Cardiac Valve Formation in Developing Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 104(2):303-311
Chen, J., Carney, S.A., Peterson, R.E., and Heideman, W. (2008) Comparative Genomics Identifies Genes Mediating Cardiotoxicity in the Embryonic Zebrafish Heart. Physiological Genomics. 33(2):148-158
Lipinski, R.J., Dengler, E., Kiehn, M., Peterson, R.E., and Bushman, W. (2007) Identification and Characterization of Several Dietary Alkaloids as Weak Inhibitors of Hedgehog Signaling. Toxicological sciences : an official journal of the Society of Toxicology. 100(2):456-463
King Heiden, T.C., Dengler, E., Kao, W.J., Heideman, W., and Peterson, R.E. (2007) Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicology and applied pharmacology. 225(1):70-79
Kim, K.H., Antkiewicz, D.S., Yan, L., Eliceir, K.W., Heideman, W., Peterson, R.E., and Lee, Y. (2007) Lrrc10 is required for early heart development and function in zebrafish. Developmental Biology. 308(2):494-506
Antkiewicz, D.S., Peterson, R.E., and Heideman, W. (2006) Blocking Expression of AHR2 and ARNT1 in Zebrafish Larvae Protects Against Cardiac Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 94(1):175-182
Carney, S.A., Chen, J., Burns, C.G., Xiong, K.M., Peterson, R.E., and Heideman, W. (2006) Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Molecular pharmacology. 70(2):549-561
Wang, Y.H., Chen, Y.H., Wu, T.N., Lin, Y.J., and Tsai, H.J. (2006) A keratin 18 transgenic zebrafish Tg(k18(2.9):RFP) treated with inorganic arsenite reveals visible overproliferation of epithelial cells. Toxicology letters. 163(3):191-197
Prasch, A.L., Tanguay, R.L., Mehta, V., Heideman, W., and Peterson, R.E. (2006) Identification of Zebrafish ARNT1 Homologs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Developing Zebrafish Requires ARNT1. Molecular pharmacology. 69(3):776-787
Carney, S.A., Prasch, A.L., Heideman, W., and Peterson, R.E. (2006) Understanding dioxin developmental toxicity using the zebrafish model. Birth defects research. Part A, Clinical and molecular teratology. 76(1):7-18
Hill, A.J., Teraoka, H., Heideman, W., and Peterson, R.E. (2005) Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 86(1):6-19
Antkiewicz, D.S., Burns, C.G., Carney, S.A., Peterson, R.E., and Heideman, W. (2005) Heart Malformation is an Early Response to TCDD in Embryonic Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 84(2):368-377
Heideman, W., Antkiewicz, D.S., Carney, S.A., and Peterson, R.E. (2005) Zebrafish and cardiac toxicology. Cardiovascular Toxicology. 5(2):203-214
Prasch, A.L., Heideman, W., and Peterson, R.E. (2004) ARNT2 Is Not Required for TCDD Developmental Toxicity in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 82(1):250-258
Carney, S.A., Peterson, R.E., and Heideman, W. (2004) 2,3,7,8-Tetrachlorodibenzo-p-dioxin Activation of the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Pathway Causes Developmental Toxicity through a CYP1A-Independent Mechanism in Zebrafish. Molecular pharmacology. 66(3):512-521
Hill, A.J., Bello, S.M., Prasch, A.L., Peterson, R.E., and Heideman, W. (2004) Water permeability and TCDD-induced edema in zebrafish early-life stages. Toxicological sciences : an official journal of the Society of Toxicology. 78(1):78-87
Prasch, A.L., Andreasen, E.A., Peterson, R.E., and Heideman, W. (2004) Interactions between TCDD and hypoxia signalling pathways in zebrafish: hypoxia decreases responses to TCDD in zebrafish embryos. Toxicological sciences : an official journal of the Society of Toxicology. 78(1):68-77
Prasch, A.L., Teraoka, H., Carney, S.A., Dong, W., Hiraga, T., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2003) Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 76(1):138-150
Cao, Z., Tanguay, R.L., McKenzie, D., Peterson, R.E., and Aiken, J.M. (2003) Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. Aquatic toxicology (Amsterdam, Netherlands). 63(3):271-282
Teraoka, H., Dong, W., Tsujimoto, Y., Iwasa, H., Endoh, D., Ueno, N., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2003) Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish. Biochemical and Biophysical Research Communications. 304(2):223-228
Dong, W., Teraoka, H., Yamazaki, K., Tsukiyama, S., Imani, S., Imagawa, T., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2002) 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. 69(1):191-201
Andreasen, E.A., Hahn, M.E., Heideman, W., Peterson, R.E., and Tanguay, R.L. (2002) The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor. Molecular pharmacology. 62(2):234-249
Andreasen, E.A., Spitsbergen, J.M., Tanguay, R.L., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2002) Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure. Toxicological sciences : an official journal of the Society of Toxicology. 68(2):403-419
Andreasen, E.A., Tanguay, R.L., Peterson, R.E., and Heideman, W. (2002) Identification of a critical amino acid in the Aryl hydrocarbon receptor. The Journal of biological chemistry. 277(15):13210-13218
Teraoka, H., Dong, W., Ogawa, S., Tsukiyama, S., Okuhara, Y., Niiyama, M., Ueno, N., Peterson, R.E., and Hiraga, T. (2002) 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: altered regional blood flow and impaired lower jaw development. Toxicological sciences : an official journal of the Society of Toxicology. 65(2):192-199
Belair, C.D., Peterson, R.E., and Heideman, W. (2001) Disruption of erythropoiesis by dioxin in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 222(4):581-594
Henry, T.R., Nesbit, D.J., Heideman, W., and Peterson, R.E. (2001) Relative potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners to induce cytochrome P4501A mRNA in a zebrafish liver cell line. Environmental toxicology and chemistry. 20(5):1053-1058
Peterson, R.E., Fadool, J.M., McClintock, J., and Linser, P.J. (2001) Müller cell differentiation in the zebrafish neural retina: Evidence of distinct early and late stages in cell maturation. The Journal of comparative neurology. 429(4):530-540
Tanguay, R.L., Andreasen, E., Heideman, W., and Peterson, R.E. (2000) Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions. Biochim. Biophys. Acta Gene Struct. Exp.. 1494(1-2):117-128
Abnet, C.C., Tanguay, R.L., Heideman, W., and Peterson, R.E. (1999) Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners. Toxicology and applied pharmacology. 159(1):41-51
Tanguay, R.L., Abnet, C.C., Heideman, W., and Peterson, R.E. (1999) Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor. Biochim. Biophys. Acta Gene Struct. Exp.. 1444:35-48
Henry, T.R., Spitsbergen, J.M., Hornung, M.W., Abnet, C.C., and Peterson, R.E. (1997) Early life stage toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in zebrafish (Danio rerio). Toxicology and applied pharmacology. 142(1):56-68
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