ZFIN ID: ZDB-LAB-970409-29
Krumlauf Lab
PI/Director: Krumlauf, Robb
Contact Person: Krumlauf, Robb
Email: rek@stowers.org
URL: http://www.stowers.org
Address: Stowers Institute for Medical Research 1000 East 50th Street Kansas City, MO 64110 USA
Country: United States
Phone: (816) 926-4051
Fax:
Line Designation: kst


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 14 genomic features


STATEMENT OF RESEARCH INTERESTS
We are interested inthe mechanisms of hindbrain segmentation and the roles that Hox homeobox genes and their regulators play in segmentation and neural crest patterning. This involves using diverse functional approaches in zebrafish, lamprey and mice.


LAB MEMBERS
Parker, Hugo Post-Doc Afzal, Zainab Graduate Student Bedois, Alice Graduate Student
Nolte, Christof Research Staff Scott, Carrie Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
Parker, H.J., De Kumar, B., Green, S.A., Prummel, K.D., Hess, C., Kaufman, C.K., Mosimann, C., Wiedemann, L.M., Bronner, M.E., Krumlauf, R. (2019) A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Nature communications. 10:1189
De Kumar, B., Parker, H.J., Paulson, A., Parrish, M.E., Zeitlinger, J., Krumlauf, R. (2017) Hoxa1 targets signaling pathways during neural differentiation of ES cells and mouse embryogenesis. Developmental Biology. 432(1):151-164
De Kumar, B., Parker, H.J., Paulson, A., Parrish, M.E., Pushel, I., Singh, N.P., Zhang, Y., Slaughter, B.D., Unruh, J.R., Florens, L., Zeitlinger, J., Krumlauf, R. (2017) HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets. Genome research. 27(9):1501-1512
McEllin, J.A., Alexander, T.B., Tümpel, S., Wiedemann, L.M., Krumlauf, R. (2016) Analyses of fugu hoxa2 genes provide evidence for subfunctionalization of neural crest cell and rhombomere cis-regulatory modules during vertebrate evolution. Developmental Biology. 409(2):530-42
Parker, H.J., Bronner, M.E., Krumlauf, R. (2014) A Hox regulatory network of hindbrain segmentation is conserved to the base of vertebrates. Nature. 514(7523):490-3
Trainor, P.A. and Krumlauf, R. (2000) Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity. Nature reviews. Neuroscience. 1(2):116-124
Manzanares, M., Trainor, P.A., Nonchev, S., Ariza-McNaughton, L., Brodie, J., Gould, A., Marshall, H., Morrison, A., Kwan, C.-T., Sham, M.-H., Wilkinson, D.G., and Krumlauf, R. (1999) The role of kreisler in segmentation during hindbrain development. Developmental Biology. 211(2):220-237
Pöpperl, H., Bienz, M., Studer, M., Chan, S., Aparicio, S., Brenner, S., Mann, R., and Krumlauf, R. (1995) Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell. 81:1031-1042
Graham, A., Papalopulu, N., Lorimer, J., McVey, J.H., Tuddenham, E.G.D., and Krumlauf, R. (1988) Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.. Genes & Development. 2(11):1424-1438