ZFIN Lab: Internal Medicinte, section Endocrinology

ZFIN ID: ZDB-LAB-210716-1

ZFIN ID: ZDB-LAB-210716-1

Internal Medicinte, section Endocrinology

PI/Director:	Timmers, Henri
Contact Person:
Email:	Margo.Dona@radboudumc.nl
URL:
Address:
Country:
Phone:	+31243655993
Fax:
Line Designation:	rmc

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Phaeochromocytoma, paraganglioma: endocrine tumours.

Phaeochromocytomas or paragangliomas (PPGLs) are chromaffin-cell tumours arising from the adrenal medulla and extra-adrenal paraganglia. PPGLs caused by mutations in the B-subunit of the succinate dehydrogenase (SDHB) have the highest metastatic rate among PPGLs, and effective systemic therapy is lacking. To unravel underlying pathogenic mechanisms, and to evaluate therapeutic strategies, suitable in vivo models are needed. For this we use the zebrafish model to study the metabolic effects of sdhb disruption during different developmental stages and develop screening assays to identify novel therapeutic targets in vivo. Besides oncological syndromes, our model might also be useful for pediatric mitochondrial diseases caused by loss of the SDHB gene.

LAB MEMBERS

Dona, Margo Post-Doc

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Dona, M., Lamers, M., Rohde, S., Gorissen, M., Timmers, H.J.L.M. (2021) Targeting the Redox Balance Pathway Using Ascorbic Acid in sdhb Zebrafish Mutant Larvae. Cancers. 13(20):

Dona, M., Waaijers, S., Richter, S., Eisenhofer, G., Korving, J., Kamel, S.M., Bakkers, J., Rapizzi, E., Rodenburg, R.J., Zethof, J., Gorissen, M., Flik, G., Deen, P.M.T., Timmers, H.J. (2020) Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics. Endocrine-related cancer. 28(1):65-77

Messchaert, M., Dona, M., Broekman, S., Peters, T.A., Corral-Serrano, J.C., Slijkerman, R.W.N., van Wijk, E., Collin, R.W.J. (2018) Eyes shut homolog is important for the maintenance of photoreceptor morphology and visual function in zebrafish. PLoS One. 13:e0200789

Corral-Serrano, J.C., Messchaert, M., Dona, M., Peters, T.A., Kamminga, L.M., van Wijk, E., Collin, R.W.J. (2018) C2orf71a/pcare1 is important for photoreceptor outer segment morphogenesis and visual function in zebrafish. Scientific Reports. 8:9675

Dona, M., Slijkerman, R., Lerner, K., Broekman, S., Wegner, J., Howat, T., Peters, T., Hetterschijt, L., Boon, N., de Vrieze, E., Sorusch, N., Wolfrum, U., Kremer, H., Neuhauss, S., Zang, J., Kamermans, M., Westerfield, M., Phillips, J., van Wijk, E. (2018) Usherin defects lead to early-onset retinal dysfunction in zebrafish. Experimental Eye Research. 173:148-159

Samarut, É., Dona, M., Yoganantharjah, P. (2017) Zebrafish Ride the Danube's Wave for the 10th European Zebrafish Meeting. Zebrafish. 15(1):79-83

Bachmann-Gagescu, R., Dona, M., Hetterschijt, L., Tonnaer, E., Peters, T., de Vrieze, E., Mans, D.A., van Beersum, S.E., Phelps, I.G., Arts, H.H., Keunen, J.E., Ueffing, M., Roepman, R., Boldt, K., Doherty, D., Moens, C.B., Neuhauss, S.C., Kremer, H., van Wijk, E. (2015) The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking. PLoS Genetics. 11:e1005575

Dona, M., Bachmann-Gagescu, R., Texier, Y., Toedt, G., Hetterschijt, L., Tonnaer, E.L., Peters, T.A., van Beersum, S.E., Bergboer, J.G., Horn, N., de Vrieze, E., Slijkerman, R.W., van Reeuwijk, J., Flik, G., Keunen, J.E., Ueffing, M., Gibson, T.J., Roepman, R., Boldt, K., Kremer, H., van Wijk, E. (2015) NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish. PLoS Genetics. 11:e1005574

van Wijk, X.M., Thijssen, V.L., Lawrence, R., van den Broek, S.A., Dona, M., Naidu, N., Oosterhof, A., van de Westerlo, E.M., Kusters, L.J., Khaled, Y., Jokela, T.A., Nowak-Sliwinska, P., Kremer, H., Stringer, S.E., Griffioen, A.W., van Wijk, E., van Delft, F.L., and van Kuppevelt, T.H. (2013) Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analog reduces angiogenesis. ACS Chemical Biology. 8(10):2331-8

Collin, R.W., Nikopoulos, K., Dona, M., Gilissen, C., Hoischen, A., Boonstra, F.N., Poulter, J.A., Kondo, H., Berger, W., Toomes, C., Tahira, T., Mohn, L.R., Blokland, E.A., Hetterschijt, L., Ali, M., Groothuismink, J.M., Duijkers, L., Inglehearn, C.F., Sollfrank, L., Strom, T.M., Uchio, E., van Nouhuys, C.E., Kremer, H., Veltman, J.A., van Wijk, E., and Cremers, F.P. (2013) ZNF408 is mutated in familial exudative vitreoretinopathy and is crucial for the development of zebrafish retinal vasculature. Proceedings of the National Academy of Sciences of the United States of America. 110(24):9856-9861