ZFIN ID: ZDB-LAB-201202-1
Esguerra Lab
PI/Director: Esguerra, Camila V.
Contact Person: Esguerra, Camila V.
Email: c.v.esguerra@ncmm.uio.no
URL: https://www.med.uio.no/ncmm/english/people/aca/camilave/index.html
Address: VISITING ADDRESS Gaustadalléen 21 Forskningsparken 0349 OSLO POSTAL ADDRESS Postboks 1137 Blindern 0318 OSLO
Country: Norway
Phone: +47 22840534
Fax:
Line Designation: uio


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Banono, Nancy Post-Doc Shojaeinia, Elham Post-Doc van der Ent, Wietske Post-Doc
Gawel, Kinga Aurelia Research Staff Kirstein-Smardzewska, Karolina Joanna Research Staff Remiro, Alejandro Pastor Research Staff
Tavara, Ana


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Banono, N.S., Gawel, K., De Witte, L., Esguerra, C.V. (2020) Zebrafish Larvae Carrying a Splice Variant Mutation in cacna1d: A New Model for Schizophrenia-Like Behaviours?. Molecular neurobiology. 58(2):877-894
Banono, N.S., Esguerra, C.V. (2020) Pharmacological Validation of the Prepulse Inhibition of Startle Response in Larval Zebrafish using a Commercial Automated System and Software. Journal of visualized experiments : JoVE. (161):
Gawel, K., Langlois, M., Martins, T., van der Ent, W., Tiraboschi, E., Jacmin, M., Crawford, A.D., Esguerra, C.V. (2020) Seizing the moment: Zebrafish epilepsy models. Neuroscience and biobehavioral reviews. 116:1-20
Gawel, K., Kukula-Koch, W., Nieoczym, D., Stepnik, K., Ent, W.V., Banono, N.S., Tarabasz, D., Turski, W.A., Esguerra, C.V. (2020) The Influence of Palmatine Isolated from Berberis sibiricaRadix on Pentylenetetrazole-Induced Seizures in Zebrafish. Cells. 9(5):
Tiraboschi, E., Martina, S., van der Ent, W., Grzyb, K., Gawel, K., Cordero-Maldonado, M.L., Poovathingal, S.K., Heintz, S., Satheesh, S.V., Brattespe, J., Xu, J., Suster, M., Skupin, A., Esguerra, C.V. (2020) New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome. Epilepsia. 61(3):549-560
Gawel, K., Turski, W.A., van der Ent, W., Mathai, B.J., Kirstein-Smardzewska, K.J., Simonsen, A., Esguerra, C.V. (2019) Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene. Molecular neurobiology. 57(4):1904-1916
Copmans, D., Kildgaard, S., Rasmussen, S.A., Ślęzak, M., Dirkx, N., Partoens, M., Esguerra, C.V., Crawford, A.D., Larsen, T.O., de Witte, P.A.M. (2019) Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B. Marine drugs. 17(11):
Kamiński, K., Socała, K., Zagaja, M., Andres-Mach, M., Abram, M., Jakubiec, M., Pieróg, M., Nieoczym, D., Rapacz, A., Gawel, K., Esguerra, C.V., Latacz, G., Lubelska, A., Szulczyk, B., Szewczyk, A., Łuszczki, J.J., Wlaź, P. (2019) N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 17(1):309-328
Gawel, K., Banono, N.S., Michalak, A., Esguerra, C.V. (2019) A critical review of zebrafish schizophrenia models: time for validation?. Neuroscience and biobehavioral reviews. 107:6-22
Princely Abudu, Y., Pankiv, S., Mathai, B.J., Håkon Lystad, A., Bindesbøll, C., Brenne, H.B., Yoke Wui Ng, M., Thiede, B., Yamamoto, A., Mutugi Nthiga, T., Lamark, T., Esguerra, C.V., Johansen, T., Simonsen, A. (2019) NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Developmental Cell. 49(4):509-525.e12
Nieoczym, D., Socała, K., Gawel, K., Esguerra, C.V., Wyska, E., Wlaź, P. (2019) Anticonvulsant Activity of Pterostilbene in Zebrafish and Mouse Acute Seizure Tests. Neurochemical research. 44(5):1043-1055
Aourz, N., Serruys, A.K., Chabwine, J., Balegamire, P.B., Afrikanova, T., Edrada-Ebel, R., Gray, A.I., Kamuhabwa, A.R., Walrave, L., Esguerra, C.V., van Leuven, F., de Witte, P.A.M., Smolders, I., Crawford, A.D. (2018) Identification of GSK-3 as a potential therapeutic entry point for epilepsy. ACS Chemical Neuroscience. 10(4):1992-2003
Franzetti, G.A., Laud-Duval, K., van der Ent, W., Brisac, A., Irondelle, M., Aubert, S., Dirksen, U., Bouvier, C., de Pinieux, G., Snaar-Jagalska, E., Chavrier, P., Delattre, O. (2017) Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells. Oncogene. 36:3505-3514
Tulotta, C., He, S., Chen, L., Groenewoud, A., van der Ent, W., Meijer, A.H., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model. Methods in molecular biology (Clifton, N.J.). 1451:155-69
Tulotta, C., He, S., van der Ent, W., Chen, L., Groenewoud, A., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model. Advances in experimental medicine and biology. 916:239-63
van der Ent, W., Veneman, W.J., Groenewoud, A., Chen, L., Tulotta, C., Hogendoorn, P.C., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Automation of Technology for Cancer Research. Advances in experimental medicine and biology. 916:315-32
Zhang, Y., Kecskés, A., Copmans, D., Langlois, M., Crawford, A.D., Ceulemans, B., Lagae, L., de Witte, P.A., Esguerra, C.V. (2015) Pharmacological Characterization of an Antisense Knockdown Zebrafish Model of Dravet Syndrome: Inhibition of Epileptic Seizures by the Serotonin Agonist Fenfluramine. PLoS One. 10:e0125898
Bagci, E., Heijlen, M., Vergauwen, L., Hagenaars, A., Houbrechts, A.M., Esguerra, C.V., Blust, R., Darras, V.M., Knapen, D. (2015) Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction. PLoS One. 10:e0123285
Leclercq, K., Afrikanova, T., Langlois, M., De Prins, A., Buenafe, O.E., Rospo, C.C., Van Eeckhaut, A., de Witte, P.A., Crawford, A.D., Smolders, I., Esguerra, C.V., Kaminski, R.M. (2015) Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. Epilepsy & behavior : E&B. 45:53-63
van der Ent, W., Burrello, C., de Lange, M.J., van der Velden, P.A., Jochemsen, A.G., Jager, M.J., Snaar-Jagalska, B.E. (2015) Embryonic Zebrafish: Different Phenotypes after Injection of Human Uveal Melanoma Cells. Ocular oncology and pathology. 1:170-81
Schubert, J., Siekierska, A., Langlois, M., May, P., Huneau, C., Becker, F., Muhle, H., Suls, A., Lemke, J.R., de Kovel, C.G., Thiele, H., Konrad, K., Kawalia, A., Toliat, M.R., Sander, T., Rüschendorf, F., Caliebe, A., Nagel, I., Kohl, B., Kecskés, A., Jacmin, M., Hardies, K., Weckhuysen, S., Riesch, E., Dorn, T., Brilstra, E.H., Baulac, S., Møller, R.S., Hjalgrim, H., Koeleman, B.P., EuroEPINOMICS RES Consortium, Jurkat-Rott, K., Lehman-Horn, F., Roach, J.C., Glusman, G., Hood, L., Galas, D.J., Martin, B., de Witte, P.A., Biskup, S., De Jonghe, P., Helbig, I., Balling, R., Nürnberg, P., Crawford, A.D., Esguerra, C.V., Weber, Y.G., Lerche, H. (2014) Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes. Nature Genetics. 46(12):1327-32
Ban, J., Aryee, D.N., Fourtouna, A., van der Ent, W., Kauer, M., Niedan, S., Machado, I., Rodriguez-Galindo, C., Tirado, O.M., Schwentner, R., Picci, P., Flanagan, A.M., Berg, V., Strauss, S.J., Scotlandi, K., Lawlor, E.R., Snaar-Jagalska, E., Llombart-Bosch, A., Kovar, H. (2014) Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma. Cancer research. 74(22):6578-88
Mommaerts, H., Esguerra, C.V., Hartmann, U., Luyten, F.P., Tylzanowski, P. (2014) Smoc2 modulates embryonic myelopoiesis during zebrafish development. Developmental dynamics : an official publication of the American Association of Anatomists. 243(11):1375-90
Challal, S., Buenafe, O.E., Queiroz, E.F., Maljevic, S., Marcourt, L., Bock, M., Kloeti, W., Dayrit, F.M., Harvey, A.L., Lerche, H., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., Crawford, A.D. (2014) Zebrafish-bioassay guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum. ACS Chemical Neuroscience. 5(10):993-1004
Spincemaille, P., Pham, D.H., Chandhok, G., Verbeek, J., Zibert, A., Libbrecht, L., Schmidt, H., Esguerra, C.V., de Witte, P.A., Cammue, B.P., Cassiman, D., Thevissen, K. (2014) The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease. Toxicology and applied pharmacology. 280(2):345-51
van der Ent, W., Burrello, C., Teunisse, A.F., Ksander, B.R., Van der Velden, P.A., Jager, M.J., Jochemsen, A.G., Snaar-Jagalska, B.E. (2014) Modelling of human uveal melanoma in Zebrafish xenograft embryos. Investigative ophthalmology & visual science. 55(10):6612-22
van der Ent, W., Jochemsen, A.G., Teunisse, A.F., Krens, S.G., Szuhai, K., Spaink, H.P., Hogendoorn, P.C., Snaar-Jagalska, B.E. (2014) Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53. The Journal of pathology. 233(4):415-24
Heijlen, M., Houbrechts, A.M., Bagci, E., Van Herck, S.L., Kersseboom, S., Esguerra, C.V., Blust, R., Visser, T.J., Knapen, D., and Darras, V.M. (2014) Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish. Endocrinology. 155(4):1547-1559
Orellana-Paucar, A.M., Afrikanova, T., Thomas, J., Aibuldinov, Y.K., Dehaen, W., de Witte, P.A., and Esguerra, C.V. (2013) Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. PLoS One. 8(12):e81634
Gebruers, E., Cordero-Maldonado, M.L., Gray, A.I., Clements, C., Harvey, A.L., Edrada-Ebel, R., de Witte, P.A., Crawford, A.D., and Esguerra, C.V. (2013) A Phenotypic Screen in Zebrafish Identifies a Novel Small-Molecule Inducer of Ectopic Tail Formation Suggestive of Alterations in Non-Canonical Wnt/PCP Signaling. PLoS One. 8(12):e83293
Buenafe, O.E., Orellana Paucar, A.M., Maes, J., Huang, H., De Borggraeve, W.M., Crawford, A.D., Luyten, W., Esguerra, C.V., and de Witte, P. (2013) Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ACS Chemical Neuroscience. 4(11):1479-87
Suls, A., Jaehn, J.A., Kecskés, A., Weber, Y., Weckhuysen, S., Craiu, D.C., Siekierska, A., Djémié, T., Afrikanova, T., Gormley, P., von Spiczak, S., Kluger, G., Iliescu, C.M., Talvik, T., Talvik, I., Meral, C., Caglayan, H.S., Giraldez, B.G., Serratosa, J., Lemke, J.R., Hoffman-Zacharska, D., Szczepanik, E., Barisic, N., Komarek, V., Hjalgrim, H., Møller, R.S., Linnankivi, T., Dimova, P., Striano, P., Zara, F., Marini, C., Guerrini, R., Depienne, C., Baulac, S., Kuhlenbäumer, G., Crawford, A.D., Lehesjoki, A.E., de Witte, P.A., Palotie, A., Lerche, H., Esguerra, C.V., De Jonghe, P., and Helbig, I. (2013) De Novo Loss-of-Function Mutations in CHD2 Cause a Fever-Sensitive Myoclonic Epileptic Encephalopathy Sharing Features with Dravet Syndrome. American journal of human genetics. 93(5):967-975
Cordero-Maldonado, M.L., Siverio-Mota, D., Vicet-Muro, L., Wilches-Arizábala, I.M., Esguerra, C.V., de Witte, P.A., and Crawford, A.D. (2013) Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites. PLoS One. 8(10):e75404
Spaink, H.P., Cui, C., Wiweger, M.I., Jansen, H.J., Veneman, W.J., Marín-Juez, R., de Sonneville, J., Ordas, A., Torraca, V., van der Ent, W., Leenders, W.P., Meijer, A.H., Snaar-Jagalska, B.E., and Dirks, R.P. (2013) Robotic injection of zebrafish embryos for high-throughput screening in disease models. Methods (San Diego, Calif.). 62(3):246-54
Lauinger, I.L., Vivas, L., Perozzo, R., Stairiker, C., Tarun, A., Zloh, M., Zhang, X., Xu, H., Tonge, P.J., Franzblau, S.G., Pham, D.H., Esguerra, C.V., Crawford, A.D., Maes, L., and Tasdemir, D. (2013) Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target. Journal of natural products. 76(6):1064-1070
Bohni, N., Cordero-Maldonado, M.L., Maes, J., Siverio-Mota, D., Marcourt, L., Munck, S., Kamuhabwa, A.R., Moshi, M.J., Esguerra, C.V., de Witte, P.A., Crawford, A.D., and Wolfender, J.L. (2013) Integration of Microfractionation, qNMR and Zebrafish Screening for the In Vivo Bioassay-Guided Isolation and Quantitative Bioactivity Analysis of Natural Products. PLoS One. 8(5):e64006
Afrikanova, T., Serruys, A.S., Buenafe, O.E., Clinckers, R., Smolders, I., de Witte, P.A., Crawford, A.D., and Esguerra, C.V. (2013) Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs. PLoS One. 8(1):e54166
Orellana-Paucar, A.M., Serruys, A.S., Afrikanova, T., Maes, J., De Borggraeve, W., Alen, J., León-Tamariz, F., Wilches-Arizábala, I.M., Crawford, A.D., de Witte, P.A., and Esguerra, C.V. (2012) Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models. Epilepsy & behavior : E&B. 24(1):14-22
Challal, S., Bohni, N., Buenafe, O.E., Esguerra, C.V., de Witte, P.A., Wolfender, J.L., and Crawford, A.D. (2012) Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products. Chimia. 66(4):229-232
Ghotra, V.P., He, S., de Bont, H., van der Ent, W., Spaink, H.P., van de Water, B., Snaar-Jagalska, B.E., and Danen, E.H. (2012) Automated whole animal bio-imaging assay for human cancer dissemination. PLoS One. 7(2):e31281
Maes, J., Verlooy, L., Buenafe, O.E., de Witte, P.A., Esguerra, C.V., and Crawford, A.D. (2012) Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae. PLoS One. 7(10):e43850
Vermoesen, K., Serruys, A.S., Loyens, E., Afrikanova, T., Massie, A., Schallier, A., Michotte, Y., Crawford, A.D., Esguerra, C.V., de Witte, P.A., Smolders, I., and Clinckers, R. (2011) Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models. Epilepsy & behavior : E&B. 22(3):450-60
Crawford, A.D., Liekens, S., Kamuhabwa, A.R., Maes, J., Munck, S., Busson, R., Rozenski, J., Esguerra, C.V., and de Witte, P.A. (2011) Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East african medicinal plants. PLoS One. 6(2):e14694
Crawford, A.D., Esguerra, C.V., and de Witte, P.A. (2008) Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery. Planta Medica. 74(6):624-632
Esguerra, C.V., Nelles, L., Vermeire, L., Ibrahimi, A., Crawford, A.D., Derua, R., Janssens, E., Waelkens, E., Carmeliet, P., Collen, D., and Huylebroeck, D. (2007) Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. Development (Cambridge, England). 134(24):4381-4393
Yoda, H., Momoi, A., Esguerra, C.V., Meyer, D., Driever, W., Kondoh, H., and Furutani-Seiki, M. (2003) An expression pattern screen for genes involved in the induction of the posterior nervous system of zebrafish. Differentiation; research in biological diversity. 71(2):152-162
Stalmans, I., Lambrechts, D., De Smet, F., Jansen, S., Wang, J., Maity, S., Kneer, P., von der Ohe, M., Swillen, A., Maes, C., Gewillig, M., Molin, D.G., Hellings, P., Boetel, T., Haardt, M., Compernolle, V., Derwerchin, M., Plaisance, S., Vlietinck, R., Emanuel, B., Gittenberger-de Groot, A.C., Scambler, P., Morrow, B., Driscol, D.A., Moons, L., Esguerra, C.V., Carmeliet, G., Behn-Krappa, A., Devriendt, K., Collen, D., Conway, S.J., and Carmeliet, P. (2003) VEGF: a modifier of the del22q11 (DiGeorge) syndrome?. Nature medicine. 9(2):173-182
Doitsidou, M., Reichman-Fried, M., Stebler, J., Köprunner, M., Dörries, J., Meyer, D., Esguerra, C.V., Leung, T., and Raz, E. (2002) Guidance of primordial germ cell migration by the chemokine SDF-1. Cell. 111(5):647-659