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ZFIN ID: ZDB-LAB-200924-1
Gallagher Lab
PI/Director: Gallagher, Evan P.
Contact Person: Ramsden, Richard
Address: Department of environmental and occupational health sciences , 4225 Roosevelt Way NE., Suite 100 Seattle, WA 98105
Country: United States
Phone: 206- 543-1005
Line Designation: w

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Our laboratory interests are in aquatic toxicology, and chemical neurobehavioral injury, particularly on the fish olfactory system. We are using zebrafish as a laboratory model to create transgenic lines exploring the mechanisms of chemical and metal mediated olfactory injury. We are particularly interested in the role of oxidative stress as a mechanism of pollutant olfactory injury, and also the role of antioxidant genes in protecting against neurobehavioral injury.

Ramsden, Richard Research Staff

Mills, M.G., Ramsden, R., Ma, E.Y., Corrales, J., Kristofco, L.A., Steele, W.B., Saari, G.N., Melnikov, F., Kostal, J., Kavanagh, T.J., Zimmerman, J.B., Voutchkova-Kostal, A.M., Brooks, B.W., Coish, P., Anastas, P.T., Gallagher, E. (2019) CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chemical Research in Toxicology. 33(2):426-435
Steele, W.B., Kristofco, L.A., Corrales, J., Saari, G.N., Corcoran, E.J., Hill, B.N., Mills, M.G., Gallagher, E., Kavanagh, T.J., Melnikov, F., Zimmerman, J.B., Voutchkova-Kostal, A.M., Anastas, P.T., Kostal, J., Brooks, B.W. (2019) Towards less hazardous industrial compounds: coupling quantum mechanical computations, biomarker responses and behavioral profiles identify bioactivity of SN2 electrophiles in alternative vertebrate models. Chemical Research in Toxicology. 33(2):367-380
Steele, W.B., Kristofco, L.A., Corrales, J., Saari, G.N., Haddad, S.P., Gallagher, E.P., Kavanagh, T.J., Kostal, J., Zimmerman, J.B., Voutchkova-Kostal, A., Anastas, P., Brooks, B.W. (2018) Comparative behavioral toxicology with two common larval fish models: Exploring relationships among modes of action and locomotor responses. The Science of the total environment. 640-641:1587-1600
Ma, E.Y., Heffern, K., Cheresh, J., Gallagher, E.P. (2018) Differential copper-induced death and regeneration of olfactory sensory neuron populations and neurobehavioral function in larval zebrafish. Neurotoxicology. 69:141-151
Heffern, K., Tierney, K., Gallagher, E.P. (2018) Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 201:83-90
Corrales, J., Kristofco, L.A., Steele, W.B., Saari, G.N., Kostal, J., Williams, E.S., Mills, M., Gallagher, E.P., Kavanagh, T.J., Simcox, N., Shen, L.Q., Melnikov, F., Zimmerman, J.B., Voutchkova-Kostal, A.M., Anastas, P.T., Brooks, B.W. (2017) Towards the design of less hazardous chemicals: Exploring comparative oxidative stress in two common animal models. Chemical Research in Toxicology. 30(4):893-904
Mills, M.G., Gallagher, E.P. (2017) A targeted gene expression platform allows for rapid analysis of chemical-induced antioxidant mRNA expression in zebrafish larvae. PLoS One. 12:e0171025
Ramsden, R., Gallagher, E.P. (2016) Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets. Redox Biology. 9:114-123
Wang, L., Bammler, T.K., Beyer, R.P., and Gallagher, E.P. (2013) Copper-Induced Deregulation of microRNA Expression in the Zebrafish Olfactory System. Environmental science & technology. 47(13):7466-7474
Wang, L., and Gallagher, E.P. (2013) Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicology and applied pharmacology. 266(2):177-186
McClain, V., Stapleton, H.M., and Gallagher, E. (2012) BDE 49 and developmental toxicity in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 155(2):253-8
Tilton, F.A., Tilton, S.C., Bammler, T.K., Beyer, R.P., Stapleton, P.L., Scholz, N.L., and Gallagher, E.P. (2011) Transcriptional impact of organophosphate and metal mixtures on olfaction: Copper dominates the chlorpyrifos-induced response in adult zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 102(3-4):205-215
Tilton, F.A., Bammler, T.K., and Gallagher, E.P. (2011) Swimming impairment and acetylcholinesterase inhibition in zebrafish exposed to copper or chlorpyrifos separately, or as mixtures. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 153(1):9-16
Lefebvre, K.A., Tilton, S.C., Bammler, T.K., Beyer, R.P., Srinouanprachan, S., Stapleton, P.L., Farin, F.M., and Gallagher, E.P. (2009) Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicological sciences : an official journal of the Society of Toxicology. 107(1):65-77
Tilton, F., Tilton, S.C., Bammler, T.K., Beyer, R., Farin, F., Stapleton, P.L., and Gallagher, E.P. (2008) Transcriptional biomarkers and mechanisms of copper-induced olfactory injury in zebrafish. Environmental science & technology. 42(24):9404-9411