ZFIN ID: ZDB-LAB-200121-1
Hoffman Lab
PI/Director: Hoffman, Ellen
Contact Person: Hoffman, Ellen
Email: ellen.hoffman@yale.edu
URL: https://www.hoffmanlab.net/
Address: 333 Cedar St. New Haven CT 06510
Country: United States
Phone: 203-737-4292
Fax: 203-785-4415
Line Designation: ya


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 1 genomic features


STATEMENT OF RESEARCH INTERESTS
In the Hoffman lab, our goal is to understand the basic biological mechanisms underlying neurodevelopmental disorders, in particular autism spectrum disorders (ASD). To do this, we study the function of genes that are strongly associated with autism in humans to determine how disruption of these genes alters brain development and the neural circuits underlying simple behaviors. Our long-term goal is to use this gene-based approach to identify relevant biological pathways and novel pharmacological treatments that target these pathways.


LAB MEMBERS
Mendes, Hellen Weinschutz Post-Doc Fitzpatrick, Sarah E. Graduate Student Chen, Tianying Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Weinschutz Mendes, H., Neelakantan, U., Liu, Y., Fitzpatrick, S.E., Chen, T., Wu, W., Pruitt, A., Jin, D.S., Jamadagni, P., Carlson, M., Lacadie, C.M., Enriquez, K.D., Li, N., Zhao, D., Ijaz, S., Sakai, C., Szi, C., Rooney, B., Ghosh, M., Nwabudike, I., Gorodezky, A., Chowdhury, S., Zaheer, M., McLaughlin, S., Fernandez, J.M., Wu, J., Eilbott, J.A., Vander Wyk, B., Rihel, J., Papademetris, X., Wang, Z., Hoffman, E.J. (2023) High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports. 42:112243112243
Kroll, F., Powell, G.T., Ghosh, M., Gestri, G., Antinucci, P., Hearn, T.J., Tunbak, H., Lim, S., Dennis, H.W., Fernandez, J.M., Whitmore, D., Dreosti, E., Wilson, S.W., Hoffman, E.J., Rihel, J. (2021) A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes. eLIFE. 10:
Sakai, C., Ijaz, S., Hoffman, E.J. (2018) Zebrafish Models of Neurodevelopmental Disorders: Past, Present, and Future. Frontiers in molecular neuroscience. 11:294
Ijaz, S., Hoffman, E.J. (2016) Zebrafish: A Translational Model System for Studying Neuropsychiatric Disorders. Journal of the American Academy of Child and Adolescent Psychiatry. 55:746-8
Hoffman, E.J., Turner, K.J., Fernandez, J.M., Cifuentes, D., Ghosh, M., Ijaz, S., Jain, R.A., Kubo, F., Bill, B.R., Baier, H., Granato, M., Barresi, M.J., Wilson, S.W., Rihel, J., State, M.W., Giraldez, A.J. (2016) Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2. Neuron. 89(4):725-33
Sander, J.D., Dahlborg, E.J., Goodwin, M.J., Cade, L., Zhang, F., Cifuentes, D., Curtin, S.J., Blackburn, J.S., Thibodeau-Beganny, S., Qi, Y., Pierick, C.J., Hoffman, E., Maeder, M.L., Khayter, C., Reyon, D., Dobbs, D., Langenau, D.M., Stupar, R.M., Giraldez, A.J., Voytas, D.F., Peterson, R.T., Yeh, J.R., Joung, J.K. (2011) Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nature Methods. 8:67-9
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