ZFIN ID: ZDB-LAB-200115-1
PI/Director: Miñana, Rafael
Contact Person: Miñana, Rafael
Email: rafael.minana@zeclinics.com
URL: http://www.zeclinics.com
Country: Spain
Phone: +34 937 376 114
Line Designation: ze


ZeClinics is a Biotech Contract Research Organization (CRO) company using zebrafish (Danio rerio) for safety and efficacy screenings of novel chemical molecules. Our business strengths rely on high technical expertise and top-notch research facilities, combined with attractive strategic partnerships and academic collaborations. We aim to challenge the traditional drug discovery pipeline by offering a cheap, fast, and reliable array of customized assays to assess the safety and biomedical relevance of novel molecules using zebrafish. In a challenging economic environment, ZeClinics represents an excellent example of a business model that uses research and innovation as a way to succeed.

Mejias, Laia Fish Facility Staff Bartolomé, Carles Cornet Cortes-Campos, Christian
De Santis, Flavia Di Giacomo, Valeria Dyballa, Slyvia
Fernandez, Jessica Garcia Ortiz, Sergio Jarque Terriente, Javier

Rubbini, D., Cornet, C., Terriente, J., Di Donato, V. (2020) CRISPR Meets Zebrafish: Accelerating the Discovery of New Therapeutic Targets. SLAS discovery : advancing life sciences R & D. 25(6):552-567
Cornet, C., Dyballa, S., Terriente, J., Di Giacomo, V. (2019) ZeOncoTest: Refining and Automating the Zebrafish Xenograft Model for Drug Discovery in Cancer. Pharmaceuticals (Basel, Switzerland). 13(1):
Dyballa, S., Miñana, R., Rubio-Brotons, M., Cornet, C., Pederzani, T., Escaramis, G., Garcia-Serna, R., Mestres, J., Terriente, J. (2019) Comparison of zebrafish larvae and hiPSC cardiomyocytes for predicting drug induced cardiotoxicity in humans. Toxicological sciences : an official journal of the Society of Toxicology.
Jarque, S., Ibarra, J., Rubio-Brotons, M., García-Fernández, J., Terriente, J. (2019) Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish. International Journal of Molecular Sciences. 20(7):
Pant, D.C., Dorboz, I., Schlüter, A., Fourcade, S., Launay, N., Joya, J., Aguilera-Albesa, S., Yoldi, M.E., Casasnovas, C., Willis, M.J., Ruiz, M., Ville, D., Lesca, G., Siquier-Pernet, K., Desguerre, I., Yan, H., Wang, J., Burmeister, M., Brady, L., Tarnopolsky, M., Cornet, C., Rubbini, D., Terriente, J., James, K.N., Musaev, D., Zaki, M.S., Patterson, M.C., Lanpher, B.C., Klee, E.W., Pinto E Vairo, F., Wohler, E., Sobreira, N.L.M., Cohen, J.S., Maroofian, R., Galehdari, H., Mazaheri, N., Shariati, G., Colleaux, L., Rodriguez, D., Gleeson, J.G., Pujades, C., Fatemi, A., Boespflug-Tanguy, O., Pujol, A. (2019) Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy. The Journal of Clinical Investigation. 129(3):1240-1256
Cornet, C., Di Donato, V., Terriente, J. (2018) Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline. Frontiers in pharmacology. 9:703
Ward, R., Sundaramurthi, H., Di Giacomo, V., Kennedy, B.N. (2018) Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish. Frontiers in cell and developmental biology. 6:37
Di Donato, V., De Santis, F., Albadri, S., Auer, T.O., Duroure, K., Charpentier, M., Concordet, J.P., Gebhardt, C., Del Bene, F. (2018) An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System. Neuron. 97(5):1049-1062.e6
Cornet, C., Calzolari, S., Miñana-Prieto, R., Dyballa, S., van Doornmalen, E., Rutjes, H., Savy, T., D'Amico, D., Terriente, J. (2017) ZeGlobalTox: An Innovative Approach to Address Organ Drug Toxicity Using Zebrafish. International Journal of Molecular Sciences. 18(4)
Fontenas, L., De Santis, F., Di Donato, V., Degerny, C., Chambraud, B., Del Bene, F., Tawk, M. (2016) Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. PLoS Genetics. 12:e1006459
Di Donato, V., De Santis, F., Auer, T., Testa, N., Sánchez-Iranzo, H., Mercader, N., Concordet, J.P., Del Bene, F. (2016) 2C-Cas9: a versatile tool for clonal analysis of gene function. Genome research. 26(5):681-92
De Santis, F., Di Donato, V., Del Bene, F. (2016) Clonal analysis of gene loss of function and tissue-specific gene deletion in zebrafish via CRISPR/Cas9 technology. Methods in cell biology. 135:171-88
D'Amico, D., Estivill, X., Terriente, J. (2015) Switching to zebrafish neurobehavioral models: The obsessive-compulsive disorder paradigm. European Journal of Pharmacology. 759:142-50