ZFIN ID: ZDB-LAB-191029-1
Akinori Kawamura Lab
PI/Director: Kawamura, Akinori
Contact Person: Kawamura, Akinori
Email: akawamur@mail.saitama-u.ac.jp
URL: http://devbiol.seitai.saitama-u.ac.jp/
Address: Division of Life Science Graduate School of Science and Engineering Saitama University Shimo-Okubo 255, Sakura-ku Saitama 338-8570
Country: Japan
Phone: 81-48-858-3808
Fax: 81-48-858-3408
Line Designation: sud

Show all 7 genomic features

Our research is focusing on zebrafish hox genes, which are composed of 48 hox genes located on seven hox clusters.
Recently, we generated a complete set of all of the seven individual hox cluster mutants by the CRISPR-Cas9 system
By developmental genetic approach using these mutants, we try to decipher the vertebrate Hox code underlying the vertebrate body formation.


Takahashi, K., Ito, Y., Yoshimura, M., Nikaido, M., Yuikawa, T., Kawamura, A., Tsuda, S., Kage, D., Yamasu, K. (2020) A globin-family protein, cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish. Developmental Biology. 472:1-17
Akama, K., Ebata, K., Maeno, A., Taminato, T., Otosaka, S., Gengyo-Ando, K., Nakai, J., Yamasu, K., Kawamura, A. (2019) Role of somite patterning in the formation of Weberian apparatus and pleural rib in zebrafish. Journal of anatomy. 236(4):622-629
Ban, H., Yokota, D., Otosaka, S., Kikuchi, M., Kinoshita, H., Fujino, Y., Yabe, T., Ovara, H., Izuka, A., Akama, K., Yamasu, K., Takada, S., Kawamura, A. (2019) Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation. Development (Cambridge, England). 146(18):
Fujino, Y., Yamada, K., Sugaya, C., Ooka, Y., Ovara, H., Ban, H., Akama, K., Otosaka, S., Kinoshita, H., Yamasu, K., Mishima, Y., Kawamura, A. (2018) Deadenylation by the CCR4-NOT complex contributes to the turnover of hairy-related mRNAs in the zebrafish segmentation clock. FEBS letters. 592(20):3388-3398
Kinoshita, H., Ohgane, N., Fujino, Y., Yabe, T., Ovara, H., Yokota, D., Izuka, A., Kage, D., Yamasu, K., Takada, S., Kawamura, A. (2018) Functional roles of the Ripply-mediated suppression of segmentation gene expression at the anterior presomitic mesoderm in zebrafish. Mechanisms of Development. 152:21-31
Taminato, T., Yokota, D., Araki, S., Ovara, H., Yamasu, K., Kawamura, A. (2016) Enhancer activity-based identification of functional enhancers using zebrafish embryos. Genomics. 108(2):102-7
Kawamura, A., Ovara, H., Ooka, Y., Kinoshita, H., Hoshikawa, M., Nakajo, K., Yokota, D., Fujino, Y., Higashijima, S.I., Takada, S., Yamasu, K. (2016) Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR. Developmental Biology. 409(2):543-54
Nakayama, Y., Kikuta, H., Kanai, M., Yoshikawa, K., Kawamura, A., Kobayashi, K., Wang, Z., Khan, A., Kawakami, K., and Yamasu, K. (2013) Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner. Mechanisms of Development. 130(11-12):532-52
Khan, A., Nakamoto, A., Okamoto, S., Tai, M., Nakayama, Y., Kobayashi, K., Kawamura, A., Takeda, H., and Yamasu, K. (2012) Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages. Mechanisms of Development. 129(9-12):219-235
Khan, A., Nakamoto, A., Tai, M., Saito, S., Nakayama, Y., Kawamura, A., Takeda, H., and Yamasu, K. (2012) Mesendoderm specification depends on the function of Pou2, the class V POU-type transcription factor, during zebrafish embryogenesis. Development, growth & differentiation. 54(7):686-701
Ota, S., Tonou-Fujimori, N., Nakayama, Y., Ito, Y., Kawamura, A., and Yamasu, K. (2010) FGF receptor gene expression and its regulation by FGF signaling during early zebrafish development. Genesis (New York, N.Y. : 2000). 48(12):707-716
Kawamura, A., Koshida, S., and Takada, S. (2008) Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators. Molecular and cellular biology. 28(10):3236-3244
Akanuma, T., Koshida, S., Kawamura, A., Kishimoto, Y., and Takada, S. (2007) Paf1 complex homologues are required for Notch-regulated transcription during somite segmentation. EMBO reports. 8(9):858-863
Kawamura, A., Koshida, S., Hijikata, H., Ohbayashi, A., Kondoh, H., and Takada, S. (2005) Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. Developmental Cell. 9(6):735-744
Kawamura, A., Koshida, S., Hijikata, H., Sakaguchi, T., Kondoh, H., and Takada, S. (2005) Zebrafish Hairy/Enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites. Genes & Development. 19(10):1156-1161
Komoike, Y., Kawamura, A., Shindo, N., Sato, C., Satoh, J., Shiurba, R., and Higashinakagawa, T. (2005) Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signaling. Biochemical and Biophysical Research Communications. 328(4):858-866
Kawamura, A., Yokota, S., Yamada, K., Inoue, H., Inohaya, K., Yamazaki, K., Yasumasu, I., and Higashinakagawa, T. (2002) pc1 and psc1, zebrafish homologs of Drosophila Polycomb and Posterior sex combs, encode nuclear proteins capable of complex interactions. Biochemical and Biophysical Research Communications. 294(2):456-463
Kawamura, A., Yamada, K., Fujimori, K., and Higashinakagawa, T. (2002) Alternative transcripts of a polyhomeotic gene homolog are expressed in distinct regions of somites during segmentation of zebrafish embryos. Biochemical and Biophysical Research Communications. 291(2):245-254