Community Action Needed: Please respond to the NIH RFI
ZFIN ID: ZDB-LAB-191022-1
Julia Dallman Lab
PI/Director: Dallman, Julia
Contact Person: Dallman, Julia
Address: UM/G-Biology Dept X000153 1301 Memorial Drive, Rm 215 Miami, FL 33146
Country: United States
Phone: 305 284 3954
Fax: 305 284 3039
Line Designation: umi

Show all 3 genomic features

The central goal of the Dallman lab is to determine mechanisms by which genes produce symptoms of disease. To address this question, my group generates zebrafish models of inherited human neurological disorders to understand how mutations impact development and produce resulting symptoms. By comparing multiple forms of a single disorder, we elucidate both shared and distinct mechanisms by which different mutations produce symptoms such as altered sensory processing and gastrointestinal dysmotility. Our long-term goal is to elucidate underlying mechanisms that can inform treatment strategies for individuals with inherited nervous system disorders such as autism spectrum disorder (ASD).

Davidson, Elizabeth Graduate Student James, David Graduate Student Sumathipala, Sureni Graduate Student

James, D.M., Davidson, E.A., Yanes, J., Moshiree, B., Dallman, J.E. (2021) The Gut-Brain-Microbiome Axis and Its Link to Autism: Emerging Insights and the Potential of Zebrafish Models. Frontiers in cell and developmental biology. 9:662916
Venincasa, M.J., Randlett, O., Sumathipala, S.H., Bindernagel, R., Stark, M.J., Yan, Q., Sloan, S.A., Buglo, E., Meng, Q.C., Engert, F., Züchner, S., Kelz, M.B., Syed, S., Dallman, J.E. (2021) Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia. Scientific Reports. 11:3148
Buglo, E., Sarmiento, E., Martuscelli, N.B., Sant, D.W., Danzi, M.C., Abrams, A.J., Dallman, J.E., Züchner, S. (2020) Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. PLoS One. 15:e0230566
James, D.M., Kozol, R.A., Kajiwara, Y., Wahl, A.L., Storrs, E.C., Buxbaum, J.D., Klein, M., Moshiree, B., Dallman, J.E. (2019) Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism. Molecular autism. 10:3
Mintz, K.J., Mercado, G., Zhou, Y., Ji, Y., Hettiarachchi, S.D., Liyanage, P.Y., Pandey, R.R., Chusuei, C.C., Dallman, J., Leblanc, R.M. (2019) Tryptophan carbon dots and their ability to cross the blood-brain barrier. Colloids and surfaces. B, Biointerfaces. 176:488-493
Bedell, V., Buglo, E., Marcato, D., Pylatiuk, C., Mikut, R., Stegmaier, J., Scudder, W., Wray, M., Züchner, S., Strähle, U., Peravali, R., Dallman, J.E. (2018) Zebrafish: A Pharmacogenetic Model for Anesthesia. Methods in enzymology. 602:189-209
Hung, C.Y., Volkmar, B., Baker, J.D., Bauer, J.W., Gussoni, E., Hainzl, S., Klausegger, A., Lorenzo, J., Mihalek, I., Rittinger, O., Tekin, M., Dallman, J.E., Bodamer, O.A. (2017) A defect in the inner kinetochore protein CENPT causes a new syndrome of severe growth failure. PLoS One. 12:e0189324
Yan, Q., Zhai, L., Zhang, B., Dallman, J.E. (2017) Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development. The Journal of comparative neurology. 525(7):1649-1667
Li, S., Peng, Z., Dallman, J., Baker, J., Othman, A.M., Blackwelder, P.L., Leblanc, R.M. (2016) Crossing the blood-brain-barrier with transferrin conjugated carbon dots: A zebrafish model study. Colloids and surfaces. B, Biointerfaces. 145:251-256
Kozol, R.A., Abrams, A.J., James, D.M., Buglo, E., Yan, Q., Dallman, J.E. (2016) Function Over Form: Modeling Groups of Inherited Neurological Conditions in Zebrafish. Frontiers in molecular neuroscience. 9:55
Rebelo, A.P., Abrams, A.J., Cottenie, E., Horga, A., Gonzalez, M., Bis, D.M., Sanchez-Mejias, A., Pinto, M., Buglo, E., Markel, K., Prince, J., Laura, M., Houlden, H., Blake, J., Woodward, C., Sweeney, M.G., Holton, J.L., Hanna, M., Dallman, J.E., Auer-Grumbach, M., Reilly, M.M., Zuchner, S. (2016) Cryptic Amyloidogenic Elements in the 3' UTRs of Neurofilament Genes Trigger Axonal Neuropathy. American journal of human genetics. 98(4):597-614
Koenighofer, M., Hung, C.Y., McCauley, J.L., Dallman, J., Back, E.J., Mihalek, I., Gripp, K.W., Sol-Church, K., Rusconi, P., Zhang, Z., Shi, G.X., Andres, D.A., Bodamer, O.A. (2016) Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype. Clinical genetics. 89(3):359-66
Abrams, A.J., Hufnagel, R.B., Rebelo, A., Zanna, C., Patel, N., Gonzalez, M.A., Campeanu, I.J., Griffin, L.B., Groenewald, S., Strickland, A.V., Tao, F., Speziani, F., Abreu, L., Schüle, R., Caporali, L., La Morgia, C., Maresca, A., Liguori, R., Lodi, R., Ahmed, Z.M., Sund, K.L., Wang, X., Krueger, L.A., Peng, Y., Prada, C.E., Prows, C.A., Schorry, E.K., Antonellis, A., Zimmerman, H.H., Abdul-Rahman, O.A., Yang, Y., Downes, S.M., Prince, J., Fontanesi, F., Barrientos, A., Németh, A.H., Carelli, V., Huang, T., Zuchner, S., Dallman, J.E. (2015) Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. Nature Genetics. 47(8):926-32
Kozol, R.A., Cukier, H.N., Zou, B., Mayo, V., De Rubeis, S., Cai, G., Griswold, A.J., Whitehead, P.L., Haines, J.L., Gilbert, J.R., Cuccaro, M.L., Martin, E.R., Baker, J.D., Buxbaum, J.D., Pericak-Vance, M.A., Dallman, J.E. (2015) Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis. Human molecular genetics. 24(14):4006-23
Wen, R., Dallman, J.E., Li, Y., Züchner, S.L., Vance, J.M., Peričak-Vance, M.A., Lam, B.L. (2014) Knock-Down DHDDS Expression Induces Photoreceptor Degeneration in Zebrafish. Advances in experimental medicine and biology. 801:543-50
Ganser, L.R., Yan, Q., James, V.M., Kozol, R., Topf, M., Harvey, R.J., and Dallman, J.E. (2013) Distinct phenotypes in zebrafish models of human startle disease. Neurobiology of disease. 60:139-51
Wen, H., Linhoff, M.W., Hubbard, J.M., Nelson, N.R., Stensland, D., Dallman, J., Mandel, G., and Brehm, P. (2013) Zebrafish calls for reinterpretation for the roles of p/q calcium channels in neuromuscular transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(17):7384-7392
Yariz, K.O., Duman, D., Seco, C.Z., Dallman, J., Huang, M., Peters, T.A., Sirmaci, A., Lu, N., Schraders, M., Skromne, I., Oostrik, J., Diaz-Horta, O., Young, J.I., Tokgoz-Yilmaz, S., Konukseven, O., Shahin, H., Hetterschijt, L., Kanaan, M., Oonk, A.M., Edwards, Y.J., Li, H., Atalay, S., Blanton, S., Desmidt, A.A., Liu, X.Z., Pennings, R.J., Lu, Z., Chen, Z.Y., Kremer, H., and Tekin, M. (2012) Mutations in OTOGL, Encoding the Inner Ear Protein Otogelin-like, Cause Moderate Sensorineural Hearing Loss. American journal of human genetics. 91(5):872-882
Zuchner, S., Dallman, J., Wen, R., Beecham, G., Naj, A., Farooq, A., Kohli, M.A., Whitehead, P.L., Hulme, W., Konidari, I., Edwards, Y.J., Cai, G., Peter, I., Seo, D., Buxbaum, J.D., Haines, J.L., Blanton, S., Young, J., Alfonso, E., Vance, J.M., Lam, B.L., and Periak-Vance, M.A. (2011) Whole-Exome Sequencing Links a Variant in DHDDS to Retinitis Pigmentosa. American journal of human genetics. 88(2):201-206
Ganser, L.R., and Dallman, J.E. (2009) Glycinergic synapse development, plasticity, and homeostasis in zebrafish. Frontiers in molecular neuroscience. 2:30
Luna, V.M., Wang, M., Ono, F., Gleason, M.R., Dallman, J.E., Mandel, G., and Brehm, P. (2004) Persistent electrical coupling and locomotory dysfunction in the zebrafish mutant shocked. Journal of neurophysiology. 92(4):2003-2009