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ZFIN ID: ZDB-LAB-190910-1
Eisenhoffer Lab
PI/Director: Eisenhoffer, George
Contact Person: Watson, Lisa
Address: The University of Texas MD Anderson Cancer Center Department of Genetics 1515 Holcombe Blvd., Unit 1010 Houston, Texas 77030
Country: United States
Phone: (713) 563-3174
Fax: (713) 834 6319
Line Designation: utm

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Our research focuses on understanding how cell division and death are coordinated to control overall cell numbers in epithelia. Epithelial tissues provide an essential protective barrier for the body and organs they encase, and are the primary sites where most solid tumors or carcinomas form. Alterations in both cell loss and proliferation have been implicated in numerous human diseases, including cancer, yet our knowledge of how these two processes influence each other to regulate cell numbers within normal epithelia remains limited. The goal of our research is to elucidate the mechanisms that regulate epithelial cell turnover while preserving barrier function. To investigate cell turnover in a living epithelial tissue, we have developed tools to study this process using the epidermis of developing zebrafish. This system provides unparalleled access to analyze epithelial cell turnover in vivo and in real time. We utilize a combinatorial approach that involves time lapse imaging and reverse genetic techniques to characterize cell turnover under physiological conditions, after damage, and when turnover is perturbed to gain a better understanding of the specific alterations that lead to epithelial pathologies and cancer.

Atieh, Youmna Post-Doc Yen, Shou-Ting Post-Doc Essien, Safia Graduate Student
Nguyen, Anh Trinh Graduate Student Ruiz, Oscar E. Research Staff Kahan, Philip Technical Staff
Samms, Krystin Technical Staff Watson, Lisa Administrative Staff

Wurster, S., Ruiz, O.E., Samms, K.M., Tatara, A.M., Albert, N.D., Kahan, P.H., Nguyen, A.T., Mikos, A.G., Kontoyiannis, D.P., Eisenhoffer, G.T. (2021) EGF-mediated suppression of cell extrusion during mucosal damage attenuates opportunistic fungal invasion. Cell Reports. 34:108896
Atieh, Y., Wyatt, T., Zaske, A.M., Eisenhoffer, G.T. (2020) Pulsatile contractions promote apoptotic cell extrusion in epithelial tissues. Current biology : CB. 31(6):1129-1140.e4
Yen, S.T., Trimmer, K.A., Aboul-Fettouh, N., Mullen, R.D., Culver, J.C., Dickinson, M.E., Behringer, R.R., Eisenhoffer, G.T. (2020) CreLite: An Optogenetically Controlled Cre/loxP System Using Red Light. Developmental dynamics : an official publication of the American Association of Anatomists. 249(11):1394-1403
Flores, E.M., Nguyen, A.T., Odem, M.A., Eisenhoffer, G.T., Krachler, A.M. (2019) The Zebrafish as a Model for Gastrointestinal Tract - Microbe Interactions. Cellular Microbiology. 22(3):e13152
Cantu Gutierrez, A., Cantu Gutierrez, M., Rhyner, A.M., Ruiz, O.E., Eisenhoffer, G.T., Wythe, J.D. (2019) FishNET: An automated relational database for zebrafish colony management. PLoS Biology. 17:e3000343
Watson, L., Keatinge, M., Gegg, M., Bai, Q., Sandulescu, C., Vardi, A., Futerman, A.H., Schapira, A.H.V., Burton, E.A., Bandmann, O. (2019) Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease. Neurobiology of disease. 127:563-569
Brock, C.K., Wallin, S.T., Ruiz, O.E., Samms, K.M., Mandal, A., Sumner, E.A., Eisenhoffer, G.T. (2019) Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance. Nature communications. 10:1044
Franco, J., Atieh, Y., Bryan, C.D., Kwan, K.M., Eisenhoffer, G.T. (2019) Cellular Crowding Influences Extrusion and Proliferation to Facilitate Epithelial Tissue Repair. Molecular biology of the cell. 30(16):1890-1899
Eisenhoffer, G.T., Slattum, G., Ruiz, O.E., Otsuna, H., Bryan, C.D., Lopez, J., Wagner, D.S., Bonkowsky, J.L., Chien, C.B., Dorsky, R.I., Rosenblatt, J. (2017) A toolbox to study epidermal cell types in zebrafish. Journal of Cell Science. 130(1):269-277