ZFIN ID: ZDB-LAB-190806-1
Rämet Lab
PI/Director: Rämet, Mika
Contact Person: Hannaleena, Pippo
Email: hannaleena.piippo@tuni.fi
URL: http://www.uta.fi/bmt/institute/research/ramet/contactsfi.html
Address: Arvo Ylpön katu 34, 33520 Tampere
Country: Finland
Phone: +358 50 433 6276
Line Designation: tpu

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In order to understand the function of genes associated to diseases, valid in vivo model organisms are required. Our research group uses fruit flies and zebrafish to identify key genes and proteins involved in the immune response. For this purpose, we have set up an RNA interference (RNAi) based genome-wide screening method in fruit fly S2 cells (Rämet et al. (2002) Nature) as well as conducted a large scale transposon-based forward genetic screen in zebrafish. All in all, these systems enable us to identify novel genetic associations to diseases, and they serve as a starting point for further immunological research using e.g. our well-established model for tuberculosis.

Saralahti, Anni Post-Doc Valanne, Susanna Post-Doc Vesala, Laura Post-Doc
Harjula, Sanna Graduate Student Järvelä-Stölting, Mirva Graduate Student Niskanen, Mirja Graduate Student
Uusi-Mäkelä, Meri Graduate Student Hannaleena, Pippo Research Staff Mäkinen, Leena Research Staff

Terzioglu, M., Saralahti, A., Piippo, H., Rämet, M., Andressoo, J.O. (2020) Improving CRISPR/Cas9 mutagenesis efficiency by delaying the early development of zebrafish embryos. Scientific Reports. 10:21023
Saralahti, A.K., Uusi-Mäkelä, M.I.E., Niskanen, M.T., Rämet, M. (2020) Integrating fish models in tuberculosis vaccine development. Disease models & mechanisms. 13(8):
Niskanen, M., Myllymäki, H., Rämet, M. (2020) DNA vaccination with the Mycobacterium marinum MMAR_4110 antigen inhibits reactivation of a latent mycobacterial infection in the adult Zebrafish. Vaccine. 38(35):5685-5694
Harjula, S.E., Saralahti, A.K., Ojanen, M.J.T., Rantapero, T., Uusi-Mäkelä, M.I.E., Nykter, M., Lohi, O., Parikka, M., Rämet, M. (2019) Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Developmental and comparative immunology. 103:103523
Ojanen, M.J.T., Uusi-Mäkelä, M.I.E., Harjula, S.E., Saralahti, A.K., Oksanen, K.E., Kähkönen, N., Määttä, J.A.E., Hytönen, V.P., Pesu, M., Rämet, M. (2019) Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Scientific Reports. 9:995
Luukinen, H., Hammarén, M.M., Vanha-Aho, L.M., Svorjova, A., Kantanen, L., Järvinen, S., Luukinen, B.V., Dufour, E., Rämet, M., Hytönen, V.P., Parikka, M. (2017) Priming of innate antimycobacterial immunity by heat-killed Listeria monocytogenes induces sterilizing response in the adult zebrafish tuberculosis model.. Disease models & mechanisms. 11(1)