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ZFIN ID: ZDB-LAB-181127-2
Laboratory for Vascular Morphogenesis
PI/Director: Phng, Li-Kun
Contact Person: Phng, Li-Kun
Address: RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku Kobe 650-0047
Country: Japan
Phone: +81 (0)78-306-3195
Line Designation: rk

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We are interested in understanding how blood vessels are shaped and maintained during development and homeostasis. We combine genetics, molecular biology and pharmacological approaches with high resolution time-lapse imaging to investigate how endothelial cell shape and behaviour are regulated and coordinated to build vessels of specific size and architecture in the zebrafish embryo. We are also interested in the interplay between blood flow and endothelial cell behaviour, aiming to understand how changes in haemodynamic forces impact on cell and vessel morphology.

Kondrychyn, Igor Post-Doc Taniguchi, Emi Fish Facility Staff Nomori, Akane Technical Staff

Kondrychyn, I., Kelly, D.J., Carretero, N.T., Nomori, A., Kato, K., Chong, J., Nakajima, H., Okuda, S., Mochizuki, N., Phng, L.K. (2020) Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size. Nature communications. 11:5476
Korzh, V., Kondrychyn, I. (2019) Origin and development of circumventricular organs in living vertebrate. Seminars in cell & developmental biology. 102:13-20
García-Lecea, M., Gasanov, E., Jedrychowska, J., Kondrychyn, I., Teh, C., You, M.S., Korzh, V. (2017) Development of Circumventricular Organs in the Mirror of Zebrafish Enhancer-Trap Transgenics. Frontiers in Neuroanatomy. 11:114
Kondrychyn, I., Robra, L., Thirumalai, V. (2017) Transcriptional Complexity and Distinct Expression Patterns of auts2 Paralogs in Danio rerio.. G3 (Bethesda). 7(8):2577-2593
Shen, H., Bocksteins, E., Kondrychyn, I., Snyders, D., Korzh, V. (2016) Functional antagonism of alpha-subunits of Kv channel in developing brain ventricular system. Development (Cambridge, England). 143(22):4249-4260
Poon, K.L., Liebling, M., Kondrychyn, I., Brand, T., Korzh, V. (2016) Development of the cardiac conduction system in zebrafish. Gene expression patterns : GEP. 21(2):89-96
Venkatesh, B., Lee, A.P., Ravi, V., Maurya, A.K., Lian, M.M., Swann, J.B., Ohta, Y., Flajnik, M.F., Sutoh, Y., Kasahara, M., Hoon, S., Gangu, V., Roy, S.W., Irimia, M., Korzh, V., Kondrychyn, I., Lim, Z.W., Tay, B.H., Tohari, S., Kong, K.W., Ho, S., Lorente-Galdos, B., Quilez, J., Marques-Bonet, T., Raney, B.J., Ingham, P.W., Tay, A., Hillier, L.W., Minx, P., Boehm, T., Wilson, R.K., Brenner, S., and Warren, W.C. (2014) Elephant shark genome provides unique insights into gnathostome evolution. Nature. 505(7482):174-179
Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
Kondrychyn, I., Teh, C., Sin, M., and Korzh, V. (2013) Stretching morphogenesis of the roof plate and formation of the central canal. PLoS One. 8(2):e56219
Chu, L.T., Fong, S.H., Kondrychyn, I., Loh, S.L., Ye, Z., and Korzh, V. (2012) Yolk syncytial layer formation is a failure of cytokinesis mediated by Rock1 function in the early zebrafish embryo. Biology Open. 1(8):747-753
Kondrychyn, I., Teh, C., Garcia-Lecea, M., Guan, Y., Kang, A., and Korzh, V. (2011) Zebrafish Enhancer TRAP Transgenic Line Database ZETRAP 2.0. Zebrafish. 8(4):181-182
Korzh, V., Teh, C., Kondrychyn, I., Chudakov, D.M., and Lukyanov, S. (2011) Visualizing Compound Transgenic Zebrafish in Development: A Tale of Green Fluorescent Protein and KillerRed. Zebrafish. 8(1):23-29
Poon, K.L., Liebling, M., Kondrychyn, I., Garcia-Lecea, M., and Korzh, V. (2010) Zebrafish cardiac enhancer trap lines: New tools for in vivo studies of cardiovascular development and disease. Developmental dynamics : an official publication of the American Association of Anatomists. 239(3):914-926
Winata, C.L., Korzh, S., Kondrychyn, I., Korzh, V., and Gong, Z. (2010) The role of vasculature and blood circulation in zebrafish swimbladder development. BMC Developmental Biology. 10:3
Kondrychyn, I., Garcia-Lecea, M., Emelyanov, A., Parinov, S., and Korzh, V. (2009) Genome-wide analysis of Tol2 transposon reintegration in zebrafish. BMC Genomics. 10:418
Winata, C.L., Korzh, S., Kondrychyn, I., Zheng, W., Korzh, V., and Gong, Z. (2009) Development of zebrafish swimbladder: the requirement of Hedgehog signaling in specification and organization of the three tissue layers. Developmental Biology. 331(2):222-236
Vasilyev, A., Liu, Y., Mudumana, S., Mangos, S., Lam, P.Y., Majumdar, A., Zhao, J., Poon, K.L., Kondrychyn, I., Korzh, V., and Drummond, I.A. (2009) Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology. 7(1):e9
García-Lecea, M., Kondrychyn, I., Fong, S.H., Ye, Z.R., and Korzh, V. (2008) In vivo Analysis of Choroid Plexus Morphogenesis in Zebrafish. PLoS One. 3(9):e3090
Ke, Z., Kondrichin, I., Gong, Z., and Korzh, V. (2008) Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Molecular and cellular neurosciences. 37(2):388-401
Choo, B.G., Kondrichin, I., Parinov, S., Emelyanov, A., Go, W., Toh, W.C., and Korzh, V. (2006) Zebrafish transgenic Enhancer TRAP line database (ZETRAP). BMC Developmental Biology. 6:5
Parinov, S., Kondrichin, I., Korzh, V., and Emelyanov, A. (2004) Tol2 transposon-mediated enhancer trap to identify developmentally regulated zebrafish genes in vivo. Developmental dynamics : an official publication of the American Association of Anatomists. 231(2):449-459