ZFIN ID: ZDB-LAB-180821-1
Monteiro Lab
PI/Director: Monteiro, Rui
Contact Person:
Email: mailto:r.monteiro@bham.ac.uk
URL: https://www.birmingham.ac.uk/staff/profiles/cancer-genomic/monteiro-rui.aspx
Address: Monteiro Lab IBR Stores IBR Wolfson Drive Medical School University of Birmingham Edgbaston Birmingham West Midlands B15 2TT GB
Country: United Kingdom
Phone: +44 (0)121 414 7846
Line Designation: uob

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Dr Rui Monteiro is a BHF Intermediate Basic Science Research Fellow, with a focus on the genetic programming of haemogenic endothelial cells by TGFβ signalling and in the biology of blood stem cells. The Monteiro Lab are interested in learning how extrinsic signalling impinges on lineage fate decisions during embryonic development, and how cells carry out those decisions in vivo. Understanding the molecular mechanisms underpinning the differentiation of endothelial cells and of blood stem cells in the embryo as well as the adult will inform current unsuccessful attempts to generate blood cells in vitro for therapeutic use.
Rui started as a Biochemistry undergraduate, studying Notch target genes in chick embryos. He went on to pursue a PhD in Developmental Biology at the Hubrecht Institute in Utrecht, The Netherlands. During this period and identified two BMP receptors that were required for left-right asymmetry. Later he joined Roger Patient’s lab to do research on developmental haematopoiesis. In 2014, Rui became a Principal Investigator in the Radcliffe Department of Medicine at the University of Oxford and in 2016 he became a University Research Lecturer. He has joined the University of Birmingham in 2018 as a Birmingham Fellow.

Kok, Fatma Post-Doc

Dobrzycki, T., Mahony, C.B., Krecsmarik, M., Koyunlar, C., Rispoli, R., Peulen-Zink, J., Gussinklo, K., Fedlaoui, B., de Pater, E., Patient, R., Monteiro, R. (2020) Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Communications biology. 3:71
Dobrzycki, T., Krecsmarik, M., Monteiro, R. (2020) Genotyping and Quantification of In Situ Hybridization Staining in Zebrafish. Journal of visualized experiments : JoVE. (155):
Dobrzycki, T., Lalwani, M., Telfer, C., Monteiro, R., Patient, R. (2019) The roles and controls of GATA factors in blood and cardiac development. IUBMB life. 72(1):39-44
Bonkhofer, F., Rispoli, R., Pinheiro, P., Krecsmarik, M., Schneider-Swales, J., Tsang, I.H.C., de Bruijn, M., Monteiro, R., Peterkin, T., Patient, R. (2019) Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Nature communications. 10:3577
Dobrzycki, T., Krecsmarik, M., Bonkhofer, F., Patient, R., Monteiro, R. (2018) An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation.. Biology Open. 7(4)
Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
Monteiro, R., Pouget, C., and Patient, R. (2011) The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ. The EMBO journal. 30(6):1093-1103
Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., Ten Dijke, P., and Mummery, C. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental Biology. 315(1):55-71
Kok, F.O., Oster, E., Mentzer, L., Hsieh, J.C., Henry, C.A., and Sirotkin, H.I. (2007) The role of the SPT6 chromatin remodeling factor in zebrafish embryogenesis. Developmental Biology. 307(2):214-226