ZFIN ID: ZDB-LAB-180712-1
Matrix Dynamic Lab
PI/Director: Crawford, Bryan D.
Contact Person: Crawford, Bryan D.
Email: bryanc@unb.ca
Address: 32 Bailey Hall Biology Department University of New Brunswick Fredericton, NB E3B 6E1
Country: Canada
Fax: ‭(506) 453-3583
Line Designation: unb

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My primary research foci are on cell-ECM interactions, their regulation, and how these give rise to macroscopic structure during embryonic development. In particular, I am investigating the roles of the matrix metalloproteinases and their regulators in the context of zebrafish embryogenesis.

Small, Chris Graduate Student Trieu, Nhu Graduate Student Wyatt, Rachael Graduate Student

Small, C.D., El-Khoury, M., Deslongchamps, G., Benfey, T.J., Crawford, B.D. (2020) Matrix Metalloproteinase 13 Activity is Required for Normal and Hypoxia-Induced Precocious Hatching in Zebrafish Embryos. Journal of developmental biology. 8(1):
Matchett, E.F., Wang, S., Crawford, B.D. (2019) Paralogues of Mmp11 and Timp4 Interact during the Development of the Myotendinous Junction in the Zebrafish Embryo. Journal of developmental biology. 7(4):
Fallata, A.M., Wyatt, R.A., Levesque, J.M., Dufour, A., Overall, C.M., Crawford, B.D. (2019) Intracellular Localization in Zebrafish Muscle and Conserved Sequence Features Suggest Roles for Gelatinase A Moonlighting in Sarcomere Maintenance. Biomedicines. 7(4):
Jeffrey, E.J., Crawford, B.D. (2018) The epitope-mediated MMP activation assay: detection and quantification of the activation of Mmp2 in vivo in the zebrafish embryo. Histochemistry and cell biology. 149(3):277-286
Wyatt, R.A., Trieu, N.P.V., Crawford, B.D. (2017) Zebrafish Xenograft: An Evolutionary Experiment in Tumour Biology. Genes. 8(9):220
Ellis, T.R., Crawford, B.D. (2016) Experimental Dissection of Metalloproteinase Inhibition-Mediated and Toxic Effects of Phenanthroline on Zebrafish Development. International Journal of Molecular Sciences. 17(9)
Jenkins, M.H., Alrowaished, S.S., Goody, M.F., Crawford, B.D., Henry, C.A. (2016) Laminin and Matrix metalloproteinase 11 regulate Fibronectin levels in the zebrafish myotendinous junction. Skeletal muscle. 6:18
Crawford, B.D., Po, M.D., Saranyan, P.V., Forsberg, D., Schulz, R., Pilgrim, D.B. (2014) Mmp25β facilitates elongation of sensory neurons during zebrafish development. Genesis (New York, N.Y. : 2000). 52(10):833-48
Goody, M.F., Kelly, M.W., Reynolds, C.J., Khalil, A., Crawford, B.D., and Henry, C.A. (2012) NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. PLoS Biology. 10(10):e1001409
Keow, J.Y., Pond, E.D., Cisar, J.S., Cravatt, B.F., and Crawford, B.D. (2012) Activity-based labeling of matrix metalloproteinases in living vertebrate embryos. PLoS One. 7(8):e43434
Keow, J.Y., Herrmann, K.M., Crawford, B.D. (2011) Differential in vivo zymography: A method for observing matrix metalloproteinase activity in the zebrafish embryo. Matrix biology : journal of the International Society for Matrix Biology. 30(3):169-177
Wyatt, R.A., Keow, J.Y., Harris, N.D., Haché, C.A., Li, D.H., and Crawford, B.D. (2009) The Zebrafish Embryo: A Powerful Model System for Investigating Matrix Remodeling. Zebrafish. 6(4):347-354
Wohlgemuth, S.L., Crawford, B.D., and Pilgrim, D.B. (2007) The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish. Developmental Biology. 303(2):483-492
Crawford, B.D., and Pilgrim, D.B. (2005) Ontogeny and regulation of matrix metalloproteinase activity in the zebrafish embryo by in vitro and in vivo zymography. Developmental Biology. 286(2):405-414
Manning, A.G., Crawford, B.D., Waskiewicz, A.J., and Pilgrim, D.B. (2004) UNC-119 homolog required for normal development of the zebrafish nervous system. Genesis (New York, N.Y. : 2000). 40(4):223-230
Cooper, M.S., Sommers-Herivel, G., Poage, C.T., McCarthy, M.B., Crawford, B.D., and Phillips, C. (2004) The Zebrafish DVD Exchange Project: a bioinformatics initiative. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:439-457
Crawford, B.D., Henry, C.A., Clason, T.A., Becker, A.L., and Hille, M.B. (2003) Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis. Molecular biology of the cell. 14(8):3065-3081
Henry, C.A., Crawford, B.D., Yan, Y.-L., Postlethwait, J., Cooper, M.S., and Hille, M.B. (2001) Roles for zebrafish focal adhesion kinase in notochord and somite morphogenesis. Developmental Biology. 240(2):474-487
Henry, C.A., Crawford, B.D., Sepich, D., Cooper, M.S., and Hille, M. (2000) Subcellular localization of focal adhesion kinase during zebrafish organogenesis: Distinct roles for FAK in notochord and somite morphogenesis. Molecular biology of the cell. 11:297