|ZFIN ID: ZDB-LAB-180626-1|
STATEMENT OF RESEARCH INTERESTS
Research in my lab focuses on the role of the BMP/TGFb signaling pathway in the maintenance of vascular homeostasis, control of vascular remodeling, and pathogenesis of vascular proliferative diseases, including idiopathic pulmonary arterial hypertension (IPAH), restenosis, and atherosclerosis. Our long-term objective is to understand the molecular pathogenesis of vascular proliferative diseases as a result of deregulation of the signaling pathways which are critical for a control of vascular smooth muscle cells (vSMCs) phenotype and vascular remodeling.
|Jiang, Xuan Post-Doc||Sanna, Vattulainen Post-Doc||Ghatpande, Prajakta Administrative Staff|
ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Hata, A., Lagna, G. (2019) Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia. Current opinion in hematology. 26(3):161-169
Jiang, X., Wooderchak-Donahue, W.L., McDonald, J., Ghatpande, P., Baalbaki, M., Sandoval, M., Hart, D., Clay, H., Coughlin, S., Lagna, G., Bayrak-Toydemir, P., Hata, A. (2018) Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Science signaling. 11(513)