ZFIN ID: ZDB-LAB-180503-1
Gerhardt Lab
PI/Director: Gerhardt, Holger
Co-PI / Senior
Researcher:
Collins, Russell
Contact Person: Collins, Russell
Email: Russell.Collins@mdc-berlin.de
URL: http://www.mdc-berlin.de/43637742/en/research/research_teams/integrative-vascular-biology
Address: Integrative Vascular Biology Lab Max Delbrück Center for Molecular Medicine in the Helmholtz Association Bldg 89, Room 1.04 Robert-Roessle-Str. 10 13092 Berlin
Country: Germany
Phone: 49 (0)30-9406-1770
Fax:
Line Designation: md


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 3 genomic features


STATEMENT OF RESEARCH INTERESTS
The Integrative Vascular Biology Laboratory aims to unravel the fundamental principles and molecular/genetic regulation of functional vascular network formation in development and disease. The ultimate goal of our research activities is to advance our understanding of mechanisms and molecules controlling formation and patterning of a hierarchically branched vascular network such that we can inform, innovate and implement therapeutic approaches to mitigate cardiovascular complications, and establish or restore tissue homeostasis in compromised patients. We develop and use genetic tools to image and manipulate molecules, complexes and cells in spatiotemporal controlled manner in vivo in mouse and zebrafish models. We further use iteration between predictive computational modeling and experimentation to develop hypothesis and systems level understanding of the processes at play.


LAB MEMBERS
Coxam, Baptiste Post-Doc Rosa, Andre Post-Doc Szymborska-Mell, Anna Post-Doc
de Oliveira, Marta Bastos Graduate Student Fechner, Ines Graduate Student Meier, Katja Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Bastos de Oliveira, M., Meier, K., Jung, S., Bartels-Klein, E., Coxam, B., Geudens, I., Szymborska, A., Skoczylas, R., Fechner, I., Koltowska, K., Gerhardt, H. (2021) Vasohibin-1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. Development (Cambridge, England). 148(4):
Collins, R.T., Coxam, B., Fechner, I., Unterweger, I., Szymborska, A., Meier, K., Gerhardt, H. (2020) Intron with transgenic marker (InTraM) facilitates high-throughput screening of endogenous gene reporter lines. Genesis (New York, N.Y. : 2000). 58(10-11):e23391
Geudens, I., Coxam, B., Alt, S., Gebala, V., Vion, A.C., Meier, K., Rosa, A., Gerhardt, H. (2019) Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning. Development (Cambridge, England). 146(16):
Angulo-Urarte, A., Casado, P., Castillo, S.D., Kobialka, P., Kotini, M.P., Figueiredo, A.M., Castel, P., Rajeeve, V., Milà-Guasch, M., Millan, J., Wiesner, C., Serra, H., Muixi, L., Casanovas, O., Viñals, F., Affolter, M., Gerhardt, H., Huveneers, S., Belting, H.G., Cutillas, P.R., Graupera, M. (2018) Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility. Nature communications. 9:4826
Vion, A.C., Alt, S., Klaus-Bergmann, A., Szymborska, A., Zheng, T., Perovic, T., Hammoutene, A., Oliveira, M.B., Bartels-Klein, E., Hollfinger, I., Rautou, P.E., Bernabeu, M.O., Gerhardt, H. (2018) Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression. The Journal of cell biology. 217:1651-1665
Coxam, B., Gerhardt, H. (2018) Imaging of Endothelial Cell Dynamic Behavior in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1846:181-195
Gebala, V., Collins, R., Geudens, I., Phng, L.K., Gerhardt, H. (2016) Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo. Nature cell biology. 18:443-50
Coxam, B., Neyt, C., Grassini, D.R., Le Guen, L., Smith, K.A., Schulte-Merker, S., Hogan, B.M. (2015) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 244(1):1-9
Coxam, B., Sabine, A., Bower, N.I., Smith, K.A., Pichol-Thievend, C., Skoczylas, R., Astin, J.W., Frampton, E., Jaquet, M., Crosier, P.S., Parton, R.G., Harvey, N.L., Petrova, T.V., Schulte-Merker, S., Francois, M., Hogan, B.M. (2014) Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development. Cell Reports. 7:623-33