ZFIN ID: ZDB-LAB-180119-1
Seko Lab
PI/Director: Seko, Yuko
Contact Person: Takita, Shimpei
Email: takita-shimpei@rehab.go.jp
URL: http://www.rehab.go.jp/ri/kankaku/seko/en/index.html
Address:
Country:
Phone: +81-4-2995-3100 (Ext 7347)
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Line Designation: rr


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
In the vertebrate retina, there are two types of photoreceptors, rods and cones. Retinitis Pigmentosa is the most frequent cause of inherited retinal dystrophy characterized by progressive visual loss caused by degenerative abnormalities of rods. The goal of our lab is to understand the physiological functions of its causative genes in photoreceptors and the underlying molecular mechanisms causing Retinitis Pigmentosa. To this end, we have started to use zebrafish as an animal model. The fundamental structure of retina and photoreceptors and the process to perceive light are well conserved in both humans and zebrafish. Our basic approach is to create generically modified zebrafish, for example knockout or transgenic zebrafish, and analyse phenotypes using molecular biology immunohistochemistry, biochemistry and electrophysiology in vivo.


LAB MEMBERS
Takita, Shimpei Post-Doc Miyamoto-Matsui, Kiyoko Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Takita, S., Seko, Y. (2020) eys+/- ; lrp5+/- Zebrafish Reveals Lrp5 Can Be the Receptor of Retinol in the Visual Cycle. iScience. 23:101762
Takita, S., Miyamoto-Matsui, K., Seko, Y. (2019) Intra- and interspecies comparison of EYS transcripts highlights its characteristics in the eye. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(8):9422-9433
Takita, S., Wada, Y., Kawamura, S. (2016) Effects of NDRG1 family proteins on photoreceptor outer segment morphology in zebrafish. Scientific Reports. 6:36590